Azelaic acid

Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.

Cross Reference

Introduction

To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azelaic acid?

Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azelaic acid

PubChem Associated disorders and diseases

What pathways are associated with Azelaic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azelaic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Azelaic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azelaic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Azelaic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azelaic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Azelaic acid

Download all related citations
Per page 10 20 50 100 | Total 511
Authors Title Published Journal PubMed Link
Flamigni F et al. Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of 'essential' thiol groups of ornithine decarboxylase. 1989 Biochem. J. pmid:2719637
Brinkworth RI et al. Inhibition of HIV-1 proteinase by non-peptide carboxylates. 1991 Biochem. Biophys. Res. Commun. pmid:2018518
Auld J Topical therapy of acne. 1986 Australas. J. Dermatol. pmid:2957990
Goodman G Managing acne vulgaris effectively. 2006 Aust Fam Physician pmid:16969442
Litvinov D et al. Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. 2010 Atherosclerosis pmid:19880116
Akman A et al. Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. 2007 Arch. Dermatol. Res. pmid:17710426
Schallreuter KU and Wood JW A possible mechanism of action for azelaic acid in the human epidermis. 1990 Arch. Dermatol. Res. pmid:2114832
Akamatsu H et al. Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases. 1991 Arch. Dermatol. Res. pmid:1867478
Thiboutot D New treatments and therapeutic strategies for acne. 2000 Arch Fam Med pmid:10693736
Nazzaro-Porro M et al. The depigmenting effect of azelaic acid. 1990 Arch Dermatol pmid:2073286
Elewski BE et al. A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. 2003 Arch Dermatol pmid:14623704
Czernielewski J and Liu Y Comparison of 15% azelaic acid gel and 0.75% metronidazole gel for the topical treatment of papulopustular rosacea. 2004 Arch Dermatol pmid:15492198
Liu RH et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. 2006 Arch Dermatol pmid:16924055
Wilkerson MG and Wilkin JK Azelaic acid esters do not depigment pigmented guinea pig skin. 1990 Arch Dermatol pmid:2301969
Grimes PE Melasma. Etiologic and therapeutic considerations. 1995 Arch Dermatol pmid:7492140
Száraz I and Forsling W Interaction between a capacitor electrolyte and gamma-aluminum oxide studied by Fourier transform infrared spectroscopy. 2003 Appl Spectrosc pmid:14658693
Zaffaroni N et al. Cytotoxic activity of azelaic acid against human melanoma primary cultures and established cell lines. 1990 Nov-Dec Anticancer Res. pmid:2285231
Januszewski AS et al. Lipid-derived modifications of plasma proteins in experimental and human diabetes. 2005 Ann. N. Y. Acad. Sci. pmid:16037262
Parodi A et al. Treatment of rosacea. 2011 Ann Dermatol Venereol pmid:22183101
Parodi A et al. [Treatment of rosacea]. 2011 Ann Dermatol Venereol pmid:21907876
Ortonne JP [Depigmenting chemical agents]. 1986 Ann Dermatol Venereol pmid:3800227
Reinholz M et al. Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. 2012 Ann Dermatol pmid:22577261
Park SY et al. The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant Staphylococcus aureus. 2012 Ann Dermatol pmid:22363153
Hoye TR et al. Total synthesis of peloruside A through kinetic lactonization and relay ring-closing metathesis cyclization reactions. 2010 Angew. Chem. Int. Ed. Engl. pmid:20645374
Castellucci N et al. Formation of gels in the presence of metal ions. 2011 Amino Acids pmid:21487726
Simonart T Newer approaches to the treatment of acne vulgaris. 2012 Am J Clin Dermatol pmid:22920095
Sasmaz S and Arican O Comparison of azelaic acid and anthralin for the therapy of patchy alopecia areata: a pilot study. 2005 Am J Clin Dermatol pmid:16343028
Frampton JE and Wagstaff AJ Azelaic acid 15% gel: in the treatment of papulopustular rosacea. 2004 Am J Clin Dermatol pmid:14979745
Bershad S Azelaic acid: a viewpoint by Susan Bershad. 2004 Am J Clin Dermatol pmid:14979746
Gupta AK Azelaic acid : a viewpoint by Aditya K. Gupta. 2004 Am J Clin Dermatol pmid:14979747
Marks R Acne and its management beyond the age of 35 years. 2004 Am J Clin Dermatol pmid:15663343
Rebora A The management of rosacea. 2002 Am J Clin Dermatol pmid:12180896
Quigley EA and Halpern AC Microinvasive melanoma: cutaneous pharmacotherapeutic approaches. 2013 Am J Clin Dermatol pmid:23479385
Pérez-Bernal A et al. Management of facial hyperpigmentation. 2000 Sep-Oct Am J Clin Dermatol pmid:11702317
Palassis J The sampling and determination of azelaic acid in air. 1978 Am Ind Hyg Assoc J pmid:727120
Russell JJ Topical therapy for acne. 2000 Am Fam Physician pmid:10670502
Goldgar C et al. Treatment options for acne rosacea. 2009 Am Fam Physician pmid:19725487
Feldman S et al. Diagnosis and treatment of acne. 2004 Am Fam Physician pmid:15152959
Mackrides PS and Shaughnessy AF Azelaic acid therapy for acne. 1996 Am Fam Physician pmid:8961845
Lindow KB Rosacea. An overview of diagnosis and management. 2004 Adv Nurse Pract pmid:15615217
Barabash R et al. [Nelson syndrome: a rare cause of generalized hyperpigmentation of the skin]. 2010 Jan-Feb Actas Dermosifiliogr pmid:20109395
Bjerke R et al. Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulo-pustular rosacea. 1999 Acta Derm. Venereol. pmid:10598760
Mayer-da Silva A et al. Azelaic acid vs. placebo: effects on normal human keratinocytes and melanocytes. Electron microscopic evaluation after long-term application in vivo. 1987 Acta Derm. Venereol. pmid:2438874
Breathnach AS et al. Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2672685
Mayer-da-Silva A et al. Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2475995
Töpert M et al. Pharmacology and toxicology of azelaic acid. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528255
Cunliffe WJ and Holland KT Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528256
Katsambas A et al. Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528257
Cavicchini S and Caputo R Long-term treatment of acne with 20% azelaic acid cream. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528258
Hjorth N and Graupe K Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. 1989 Acta Derm Venereol Suppl (Stockh) pmid:2528259