| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Han S et al. | Application of HPLC with ELSD detection for the assessment of azelaic acid impurities in liposomal formulation. | 2013 | ScientificWorldJournal | pmid:24228008 |
| Gołębiowski M et al. | Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species. | 2014 | J. Appl. Microbiol. | pmid:24238211 |
| Sieber MA and Hegel JK | Azelaic acid: Properties and mode of action. | 2014 | Skin Pharmacol Physiol | pmid:24280644 |
| Vargas-Diez E et al. | Azelaic acid in the treatment of acne in adult females: case reports. | 2014 | Skin Pharmacol Physiol | pmid:24280645 |
| Mayer-da Silva A et al. | Azelaic acid vs. placebo: effects on normal human keratinocytes and melanocytes. Electron microscopic evaluation after long-term application in vivo. | 1987 | Acta Derm. Venereol. | pmid:2438874 |
| Draelos ZD et al. | Azelaic acid foam 15% in the treatment of papulopustular rosacea: a randomized, double-blind, vehicle-controlled study. | 2013 | Cutis | pmid:24416747 |
| Bojar RA et al. | Azelaic acid: its uptake and mode of action in Staphylococcus epidermidis NCTC 11047. | 1988 | J. Appl. Bacteriol. | pmid:2459099 |
| pmid:24591049 | ||||
| Shariff A et al. | Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. | 2014 | Dermatol. Online J. | pmid:24656277 |
| Wang C et al. | Free radicals mediate systemic acquired resistance. | 2014 | Cell Rep | pmid:24726369 |
| Detmar M et al. | Effects of azelaic acid on proliferation and ultrastructure of mouse keratinocytes in vitro. | 1989 | J. Invest. Dermatol. | pmid:2473140 |
| Del Rosso JQ et al. | Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 5: a guide on the management of rosacea. | 2014 | Cutis | pmid:24738094 |
| Mayer-da-Silva A et al. | Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2475995 |
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| Mingrone G et al. | Preliminary studies of a dicarboxylic acid as an energy substrate in man. | 1989 May-Jun | JPEN J Parenter Enteral Nutr | pmid:2503641 |
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| Cunliffe WJ and Holland KT | Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528256 |
| Katsambas A et al. | Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528257 |
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| Hjorth N and Graupe K | Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528259 |
| Verallo-Rowell VM et al. | Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2528260 |
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| Cavicchini S and Caputo R | [National and international experiences with azelaic acid cream in the treatment of papulo-pustular acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534551 |
| Giannotti B | [National and international clinical experiences with azelaic acid cream in the treatment of comedo acne]. | 1989 | G Ital Dermatol Venereol | pmid:2534552 |
| Colonna SM | [Validity of azelaic acid in the therapy of acne. Long-term clinical results]. | 1989 | G Ital Dermatol Venereol | pmid:2534553 |
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| pmid:25669434 | ||||
| pmid:25804639 | ||||
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| pmid:25890456 | ||||
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| pmid:26002568 | ||||
| pmid:26143424 | ||||
| pmid:26244354 | ||||
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| pmid:26472098 | ||||
| pmid:26563877 | ||||
| Breathnach AC et al. | Azelaic acid therapy in disorders of pigmentation. | 1989 Apr-Jun | Clin. Dermatol. | pmid:2667735 |
| Breathnach AS et al. | Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. | 1989 | Acta Derm Venereol Suppl (Stockh) | pmid:2672685 |