| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Facial Dermatoses | D005148 | 7 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Azelaic acid
Azelaic acid is a lipid of Fatty Acyls (FA) class. Azelaic acid is associated with abnormalities such as Bacterial Infections and Infection. The involved functions are known as Anabolism, Signal Transduction, Plant Immunity, Signal and Signal Transduction Pathways. Azelaic acid often locates in Body tissue. The associated genes with Azelaic acid are AZI1 gene, FKBPL gene and MLL gene. The related lipids are sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Azelaic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Azelaic acid?
Azelaic acid is suspected in Infection, Bacterial Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Azelaic acid
PubChem Associated disorders and diseases
What pathways are associated with Azelaic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Azelaic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Azelaic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Azelaic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Azelaic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Azelaic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Azelaic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Azelaic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fleischer A and Suephy C | The face and mind evaluation study: an examination of the efficacy of rosacea treatment using physician ratings and patients' self-reported quality of life. | 2005 Sep-Oct | J Drugs Dermatol | pmid:16167417 |
| Ziel K et al. | Cumulative irritation potential of metronidazole gel compared to azelaic acid gel after repeated applications to healthy skin. | 2005 Nov-Dec | J Drugs Dermatol | pmid:16302558 |
| Li H et al. | Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 | Chem. Res. Toxicol. | pmid:15962942 |
| Page MM et al. | Ion chromatographic analysis of amines, alkanolamines, and associated anions in concrete. | 2005 | J Sep Sci | pmid:15835735 |
| Januszewski AS et al. | Chemical modification of proteins during peroxidation of phospholipids. | 2005 | J. Lipid Res. | pmid:15805546 |
| Manosroi J et al. | Enhancement of the release of azelaic acid through the synthetic membranes by inclusion complex formation with hydroxypropyl-beta-cyclodextrin. | 2005 | Int J Pharm | pmid:15778061 |
| Wolf JE | Present and future rosacea therapy. | 2005 | Cutis | pmid:15810803 |
| van Zuuren EJ and Graber MA | The rigor of trials evaluating Rosacea treatments. | 2005 | Cutis | pmid:15810805 |
| Sasmaz S and Arican O | Comparison of azelaic acid and anthralin for the therapy of patchy alopecia areata: a pilot study. | 2005 | Am J Clin Dermatol | pmid:16343028 |
| Kuster GM et al. | Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. | 2005 | Circulation | pmid:15723974 |
| Callender VD | Considerations for treating acne in ethnic skin. | 2005 | Cutis | pmid:16164153 |
| Punsalan T and Usatine RP | Red facial rash with "granitos". | 2005 | J Fam Pract | pmid:16144591 |
| Roebuck HL | Face up to rosacea. | 2005 | Nurse Pract | pmid:16151303 |
| Purdy S | Acne vulgaris. | 2005 | Clin Evid | pmid:16135322 |
| Januszewski AS et al. | Lipid-derived modifications of plasma proteins in experimental and human diabetes. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16037262 |
| Hung HM et al. | Products and mechanisms of the reaction of oleic acid with ozone and nitrate radical. | 2005 | J Phys Chem A | pmid:16833788 |
| Shirokova E et al. | Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. | 2005 | J. Biol. Chem. | pmid:15598656 |
| Esposito E et al. | Ethosomes and liposomes as topical vehicles for azelaic acid: a preformulation study. | 2004 May-Jun | J Cosmet Sci | pmid:15264053 |
| Halder RM and Richards GM | Topical agents used in the management of hyperpigmentation. | 2004 Jun-Jul | Skin Therapy Lett. | pmid:15334278 |
| Cetiner S et al. | Phototoxic effects of topical azelaic acid, benzoyl peroxide and adapalene were not detected when applied immediately before UVB to normal skin. | 2004 Jul-Aug | Eur J Dermatol | pmid:15319156 |
| Yoon TY et al. | A case of idiopathic eruptive macular pigmentation. | 2004 | J. Dermatol. | pmid:15187318 |
| Azelaic acid, a new treatment for rosacea. | 2004 | Mayo Clin Womens Healthsource | pmid:15152174 | |
| Halder RM and Richards GM | Management of dyschromias in ethnic skin. | 2004 | Dermatol Ther | pmid:15113282 |
| Charnock C et al. | Evaluation of the antibacterial efficacy of diesters of azelaic acid. | 2004 | Eur J Pharm Sci | pmid:15066659 |
| Wolf JE | The role of topical metronidazole in the treatment of rosacea. | 2004 | Cutis | pmid:14959942 |
| Del Rosso JQ | Medical treatment of rosacea with emphasis on topical therapies. | 2004 | Expert Opin Pharmacother | pmid:14680431 |
| Feldman S et al. | Diagnosis and treatment of acne. | 2004 | Am Fam Physician | pmid:15152959 |
| Draelos ZD | Noxious sensory perceptions in patients with mild to moderate rosacea treated with azelaic acid 15% gel. | 2004 | Cutis | pmid:15551720 |
| Lindow KB | Rosacea. An overview of diagnosis and management. | 2004 | Adv Nurse Pract | pmid:15615217 |
| Cayce KA et al. | Hyperpigmentation: an overview of the common afflictions. | 2004 | Dermatol Nurs | pmid:15624705 |
| Frampton JE and Wagstaff AJ | Azelaic acid 15% gel: in the treatment of papulopustular rosacea. | 2004 | Am J Clin Dermatol | pmid:14979745 |
| Bershad S | Azelaic acid: a viewpoint by Susan Bershad. | 2004 | Am J Clin Dermatol | pmid:14979746 |
| Gupta AK | Azelaic acid : a viewpoint by Aditya K. Gupta. | 2004 | Am J Clin Dermatol | pmid:14979747 |
| Cluzeau J and Lubell WD | Conformationally constrained dipeptide surrogates with aromatic side-chains: synthesis of 4-aryl indolizidin-9-one amino acids by conjugate addition to a common alpha,omega-diaminoazelate enone intermediate. | 2004 | J. Org. Chem. | pmid:14987004 |
| New rosacea drug gets the red out. | 2004 | Health News | pmid:15002371 | |
| Marks R | Acne and its management beyond the age of 35 years. | 2004 | Am J Clin Dermatol | pmid:15663343 |
| Gollnick HP et al. | [Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies]. | 2004 | J Dtsch Dermatol Ges | pmid:16281587 |
| Jansen T | Azelaic acid as a new treatment for perioral dermatitis: results from an open study. | 2004 | Br. J. Dermatol. | pmid:15491447 |
| Czernielewski J and Liu Y | Comparison of 15% azelaic acid gel and 0.75% metronidazole gel for the topical treatment of papulopustular rosacea. | 2004 | Arch Dermatol | pmid:15492198 |
| LaFranchi BW et al. | Photoelectron resonance capture ionization mass spectrometry: a soft ionization source for mass spectrometry of particle-phase organic compounds. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15468105 |
| Thiboutot D et al. | Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies. | 2003 | J. Am. Acad. Dermatol. | pmid:12789172 |
| Azelaic acid (Finacea) for rosacea. | 2003 | Med Lett Drugs Ther | pmid:12968125 | |
| Kawai Y et al. | Immunochemical detection of a novel lysine adduct using an antibody to linoleic acid hydroperoxide-modified protein. | 2003 | J. Lipid Res. | pmid:12700336 |
| Liao DC | Management of acne. | 2003 | J Fam Pract | pmid:12540312 |
| Dong R and Yu LE | Investigation of surface changes of nanoparticles using TM-AFM phase imaging. | 2003 | Environ. Sci. Technol. | pmid:12854724 |
| Száraz I and Forsling W | Interaction between a capacitor electrolyte and gamma-aluminum oxide studied by Fourier transform infrared spectroscopy. | 2003 | Appl Spectrosc | pmid:14658693 |
| Gwak HS et al. | Analgesic effects of intra-nasal enkephalins. | 2003 | J. Pharm. Pharmacol. | pmid:14604463 |
| Gollnick HP and Krautheim A | Topical treatment in acne: current status and future aspects. | 2003 | Dermatology (Basel) | pmid:12566803 |
| Vermis K et al. | Burkholderia cepacia complex genomovars: utilization of carbon sources, susceptibility to antimicrobial agents and growth on selective media. | 2003 | J. Appl. Microbiol. | pmid:14632991 |
| Elewski BE et al. | A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. | 2003 | Arch Dermatol | pmid:14623704 |
| Seidler J et al. | Identification and prediction of promiscuous aggregating inhibitors among known drugs. | 2003 | J. Med. Chem. | pmid:14521410 |
| Herrero-MartÃnez JM et al. | Separation of homologues and isomers of linear alkylbenzenesulfonates by capillary electrophoresis with sodium dodecyl sulfate, carboxylic acids and bile salts. | 2003 | Electrophoresis | pmid:12601738 |
| Goulden V | Guidelines for the management of acne vulgaris in adolescents. | 2003 | Paediatr Drugs | pmid:12716217 |
| Vereecken P and Heenen M | Recurrent lentigo maligna melanoma: regression associated with local azelaic acid 20%. | 2002 Jan-Feb | Int. J. Clin. Pract. | pmid:11831841 |
| Shemer A et al. | Azelaic acid (20%) cream in the treatment of acne vulgaris. | 2002 | J Eur Acad Dermatol Venereol | pmid:12046832 |
| Ray SS et al. | Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor. | 2002 | Structure | pmid:12429091 |
| Sarkar R et al. | A comparative study of 20% azelaic acid cream monotherapy versus a sequential therapy in the treatment of melasma in dark-skinned patients. | 2002 | Dermatology (Basel) | pmid:12399672 |
| He Y et al. | [Studies on chemical constituents of root of Cichorium intybus]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774404 |
| Brune TG et al. | Unknown peaks in GC-MS analyses of Guthrie cards blood samples might be the result of sample contamination by the black markings of the card. | 2002 | J. Inherit. Metab. Dis. | pmid:12555947 |
| Del Rosso JQ | A status report on the medical management of rosacea: focus on topical therapies. | 2002 | Cutis | pmid:12469780 |
| Hojo Y et al. | Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism. | 2002 | Circ. Res. | pmid:12386148 |
| Ruan H et al. | Structure of a novel diterpenoid ester, fritillahupehin from bulbs of Fritillaria hupehensis Hsiao and K.C. Hsia. | 2002 | Fitoterapia | pmid:12234570 |
| Rebora A | The management of rosacea. | 2002 | Am J Clin Dermatol | pmid:12180896 |
| Gung BW and Dickson H | Total synthesis of (-)-minquartynoic acid: an anti-cancer, anti-HIV natural product. | 2002 | Org. Lett. | pmid:12123365 |
| Hermanns JF et al. | Assessment of topical hypopigmenting agents on solar lentigines of Asian women. | 2002 | Dermatology (Basel) | pmid:12077522 |
| Gollnick HP et al. | Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne. | 2001 Nov-Dec | Eur J Dermatol | pmid:11701404 |
| Koczorek M | ["Cleansing, topical treatment, oral administration". Controlling acne]. | 2001 | MMW Fortschr Med | pmid:11524979 |
| Pérez-Bernal A et al. | Management of facial hyperpigmentation. | 2000 Sep-Oct | Am J Clin Dermatol | pmid:11702317 |
| Hermanns JF et al. | Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: effect of depigmenting agents. | 2000 | Dermatology (Basel) | pmid:11053913 |
| Korman SH et al. | Characteristic urine organic acid profile in peroxisomal biogenesis disorders. | 2000 | J. Inherit. Metab. Dis. | pmid:10896310 |
| Webster G | Combination azelaic acid therapy for acne vulgaris. | 2000 | J. Am. Acad. Dermatol. | pmid:10898830 |
| Russell JJ | Topical therapy for acne. | 2000 | Am Fam Physician | pmid:10670502 |
| Thiboutot D | New treatments and therapeutic strategies for acne. | 2000 | Arch Fam Med | pmid:10693736 |
| Usatine RP | The science and art of treating acne in adolescence. | 2000 | West. J. Med. | pmid:10734805 |
| Malaisse WJ et al. | Effects of aliphatic dioic acids and glycerol-1,2,3-tris(dodecanedioate) on D-glucose-stimulated insulin release in rat pancreatic islets. | 2000 | Br. J. Nutr. | pmid:11177188 |
| Gutheil WG | Application of hierarchical thermodynamic interactions to the protonation equilibria of organic polyprotic acids. | 2000 | Biophys. Chem. | pmid:11152269 |
| Bjerke R et al. | Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulo-pustular rosacea. | 1999 | Acta Derm. Venereol. | pmid:10598760 |
| Capristo E et al. | A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples. | 1999 | Clin. Chim. Acta | pmid:10556649 |
| Breathnach AS | Azelaic acid: potential as a general antitumoural agent. | 1999 | Med. Hypotheses | pmid:10362281 |
| Rocamora V et al. | Amelanotic lentigo maligna melanoma: report of a case and review of the literature. | 1999 | Cutis | pmid:10431675 |
| Maddin S | A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea. | 1999 | J. Am. Acad. Dermatol. | pmid:10365928 |
| Lowe NJ et al. | Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. | 1998 Sep-Oct | Clin Ther | pmid:9829446 |
| Kakita LS and Lowe NJ | Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. | 1998 Sep-Oct | Clin Ther | pmid:9829447 |
| Spellman MC and Pincus SH | Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acne. | 1998 Jul-Aug | Clin Ther | pmid:9737831 |
| Rodriguez-Vicente J et al. | The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. | 1998 | Cancer | pmid:9452267 |
| Usatine RP et al. | Acne vulgaris: a treatment update. | 1998 | Hosp Pract (1995) | pmid:9484299 |
| Gollnick H and Schramm M | Topical drug treatment in acne. | 1998 | Dermatology (Basel) | pmid:9557245 |
| Gollnick H and Schramm M | Topical therapy in acne. | 1998 | J Eur Acad Dermatol Venereol | pmid:9891903 |
| Jansen T and Plewig G | Advances and perspectives in acne therapy. | 1997 | Eur. J. Med. Res. | pmid:9262484 |
| Parsons PG et al. | Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells. | 1997 | Biochem. Pharmacol. | pmid:9264325 |
| Gibson JR | Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris. | 1997 | Dermatol Nurs | pmid:9392765 |
| Addo-Boadu K et al. | Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro. | 1996 | Cancer Lett. | pmid:8635147 |
| Azelaic acid-a new topical drug for acne. | 1996 | Med Lett Drugs Ther | pmid:8637482 | |
| Gibson JR | Rationale for the development of new topical treatments for acne vulgaris. | 1996 | Cutis | pmid:8654127 |
| Graupe K et al. | Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. | 1996 | Cutis | pmid:8654128 |
| Breathnach AS | Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. | 1996 | Cutis | pmid:8654129 |
| Lowe NJ | New approaches in dermatology: a clinical profile of azelaic acid. | 1996 | Cutis | pmid:8654130 |
| Nazzaro-Porro M et al. | A case of recurrent (following surgery x2) invasive malignant melanoma with satellitosis (stage IIIA) successfully resolving after azelaic acid treatment administered by several routes. | 1996 | Clin. Exp. Dermatol. | pmid:8959915 |
| Mackrides PS and Shaughnessy AF | Azelaic acid therapy for acne. | 1996 | Am Fam Physician | pmid:8961845 |
| Rodriguez-Vicente J et al. | Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. | 1996 | Pigment Cell Res. | pmid:9125756 |