phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

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What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

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All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Ding KH and Liang NC Inhibition of 5'-chloro-5'-deoxyadenosine on phosphoinositide and protein phosphorylation in swine platelets. 1995 Zhongguo Yao Li Xue Bao pmid:7660821
Jin MW et al. [Effect of phosphoinositide 4-phosphate on invasion and migration of human glioma U87 cells]. 2016 Zhongguo Dang Dai Er Ke Za Zhi pmid:27530799
Bishé B et al. Phosphoinositides in the hepatitis C virus life cycle. 2012 Viruses pmid:23202467
Jobe O et al. An anti-phosphoinositide-specific monoclonal antibody that neutralizes HIV-1 infection of human monocyte-derived macrophages. 2012 Virology pmid:22633000
Matyas GR and Alving CR Antigen-specific enhancement of natural human IgG antibodies to phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol-4-phosphate, cholesterol, and lipid A by a liposomal vaccine containing lipid A. 2011 Vaccine pmid:21624414
Alving CR and Rao M Lipid A and liposomes containing lipid A as antigens and adjuvants. 2008 Vaccine pmid:18226433
Nchoutmboube J et al. Enterovirus replication: go with the (counter)flow. 2015 Trends Microbiol. pmid:25748799
Santiago-Tirado FH and Bretscher A Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network. 2011 Trends Cell Biol. pmid:21764313
Altan-Bonnet N Lipid Tales of Viral Replication and Transmission. 2017 Trends Cell Biol. pmid:27838086
Balla A and Balla T Phosphatidylinositol 4-kinases: old enzymes with emerging functions. 2006 Trends Cell Biol. pmid:16793271
Shin HW and Nakayama K Dual control of membrane targeting by PtdIns(4)P and ARF. 2004 Trends Biochem. Sci. pmid:15450602
Tu L et al. A conserved N-terminal arginine-motif in GOLPH3-family proteins mediates binding to coatomer. 2012 Traffic pmid:22889169
Piao H et al. Metabolic activation of the HOG MAP kinase pathway by Snf1/AMPK regulates lipid signaling at the Golgi. 2012 Traffic pmid:22882253
Cheong FY et al. Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity. 2010 Traffic pmid:20573065
Tahirovic S et al. Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase. 2005 Traffic pmid:15634212
Charman M et al. Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1. 2017 Traffic pmid:28471037
Sicart A et al. PLCγ1 participates in protein transport and diacylglycerol production triggered by cargo arrival at the Golgi. 2015 Traffic pmid:25491205
Subramoniam A et al. Influence of trichloroethylene treatment on phosphoinositides in rat brain. 1989 Toxicol. Lett. pmid:2554538
Rizzo R et al. GOLPH3 and oncogenesis: What is the molecular link? 2017 Tissue Cell pmid:27378035
Mousley CJ et al. Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality. 2012 Subcell. Biochem. pmid:22374094
Minogue S and Waugh MG The phosphatidylinositol 4-kinases: don't call it a comeback. 2012 Subcell. Biochem. pmid:22403072
D'Angelo G et al. Phosphoinositides in Golgi complex function. 2012 Subcell. Biochem. pmid:22374093
Del Campo CM et al. Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. 2014 Structure pmid:24530282
Liu Y et al. Interaction of Fapp1 with Arf1 and PI4P at a membrane surface: an example of coincidence detection. 2014 Structure pmid:24462251
Levine TP and Menon AK A protein pair with PIPs inside. 2013 Structure pmid:23823324
Tong J et al. Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins. 2013 Structure pmid:23791945
Manik MK et al. Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction. 2017 Structure pmid:28319008
Zhang JQ et al. Persistency of Enlarged Autolysosomes Underscores Nanoparticle-Induced Autophagy in Hepatocytes. 2017 Small pmid:27925395
Du X et al. The role of oxysterol-binding protein and its related proteins in cancer. 2018 Semin. Cell Dev. Biol. pmid:28733164
Hammond GR et al. PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. 2012 Science pmid:22722250
Roldan ER et al. Exocytosis in spermatozoa in response to progesterone and zona pellucida. 1994 Science pmid:7985030
Baukrowitz T et al. PIP2 and PIP as determinants for ATP inhibition of KATP channels. 1998 Science pmid:9804555
Shyng SL and Nichols CG Membrane phospholipid control of nucleotide sensitivity of KATP channels. 1998 Science pmid:9804554
Fairn GD and Grinstein S Cell biology. Precursor or charge supplier? 2012 Science pmid:22879491
Moser von Filseck J et al. INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. 2015 Science pmid:26206936
Chung J et al. INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. 2015 Science pmid:26206935
Flanagan CA et al. Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. 1993 Science pmid:8248783
Borbiro I et al. Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. 2015 Sci Signal pmid:25670203
Klima M et al. Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein. 2016 Sci Rep pmid:27009356
Khadka B and Gupta RS Identification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role. 2017 Proteins pmid:28407364
Rípová D et al. Phosphoinositide signalling system in platelets of schizophrenic patients and the effect of neuroleptic therapy. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10509868
Clayton EL et al. Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. 2013 Prog. Lipid Res. pmid:23608234
Delage E et al. Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms. 2013 Prog. Lipid Res. pmid:22981911
Yanagisawa K et al. Localization of phosphatidylinositol 4,5-diphosphate on the stereocilia of cochlear hair cells. 1988 Prog. Brain Res. pmid:2847238
Stalder D et al. Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24248333
Szentpetery Z et al. Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20404150
Fairn GD et al. The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17881569
Baust T et al. Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16492770
Ungewickell A et al. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16365287
Walsh JP et al. Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. 1991 Proc. Natl. Acad. Sci. U.S.A. pmid:1656463
Watson SP and Lapetina EG 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2986126
Wassef NM et al. Suppression of phagocytic function and phospholipid metabolism in macrophages by phosphatidylinositol liposomes. 1984 Proc. Natl. Acad. Sci. U.S.A. pmid:6326135
Sohn M et al. Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:27044099
Ghugtyal V et al. Phosphatidylinositol-4-phosphate-dependent membrane traffic is critical for fungal filamentous growth. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26124136
Wang H et al. GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26038556
Jeschke A et al. Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25825728
Bianco A et al. Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity. 2012 PLoS Pathog. pmid:22412376
Banerjee S et al. Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein. 2018 PLoS Pathog. pmid:29782554
Oh HS et al. Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides. 2018 PLoS Pathog. pmid:29702686
Weber SS et al. Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. 2006 PLoS Pathog. pmid:16710455
Dorobantu CM et al. Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus. 2015 PLoS Pathog. pmid:26406250
Zhang L et al. ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. 2012 PLoS ONE pmid:22359663
Tai AW and Salloum S The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement. 2011 PLoS ONE pmid:22022594
Martín-Acebes MA et al. West Nile virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids. 2011 PLoS ONE pmid:21949814
Moriwaki Y et al. SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes. 2018 PLoS ONE pmid:29953492
Tenorio MJ et al. Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. 2016 PLoS ONE pmid:27123979
Azouaoui H et al. A high-yield co-expression system for the purification of an intact Drs2p-Cdc50p lipid flippase complex, critically dependent on and stabilized by phosphatidylinositol-4-phosphate. 2014 PLoS ONE pmid:25393116
Liu X and Ridgway ND Characterization of the sterol and phosphatidylinositol 4-phosphate binding properties of Golgi-associated OSBP-related protein 9 (ORP9). 2014 PLoS ONE pmid:25255026
Jiang K et al. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. 2016 PLoS Biol. pmid:26863604
Kim YW et al. Arabidopsis dynamin-like 2 that binds specifically to phosphatidylinositol 4-phosphate assembles into a high-molecular weight complex in vivo and in vitro. 2001 Plant Physiol. pmid:11706203
Vermeer JE et al. Imaging phosphatidylinositol 4-phosphate dynamics in living plant cells. 2009 Plant J. pmid:18785997
Zhang Q et al. Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth. 2018 Plant Cell Physiol. pmid:30107538
Saavedra L et al. Characterization of phosphatidylinositol phosphate kinases from the moss Physcomitrella patens: PpPIPK1 and PpPIPK2. 2009 Plant Cell Physiol. pmid:19188261
Gonorazky G et al. Phosphatidylinositol 4-phosphate accumulates extracellularly upon xylanase treatment in tomato cell suspensions. 2008 Plant Cell Environ. pmid:18419735
Choi Y et al. Phosphatidylinositol 3- and 4-phosphate modulate actin filament reorganization in guard cells of day flower. 2008 Plant Cell Environ. pmid:18088331
Gagne JM and Clark SE The Arabidopsis stem cell factor POLTERGEIST is membrane localized and phospholipid stimulated. 2010 Plant Cell pmid:20348433
Stenzel I et al. The type B phosphatidylinositol-4-phosphate 5-kinase 3 is essential for root hair formation in Arabidopsis thaliana. 2008 Plant Cell pmid:18178770
Jung JY et al. Phosphatidylinositol 3- and 4-phosphate are required for normal stomatal movements. 2002 Plant Cell pmid:12368494
Monks DE et al. Hyperosmotic stress induces the rapid phosphorylation of a soybean phosphatidylinositol transfer protein homolog through activation of the protein kinases SPK1 and SPK2. 2001 Plant Cell pmid:11340192
Okazaki K et al. Phosphatidylinositol 4-phosphate negatively regulates chloroplast division in Arabidopsis. 2015 Plant Cell pmid:25736058
Gonorazky G et al. Phosphatidylinositol 4-phosphate is associated to extracellular lipoproteic fractions and is detected in tomato apoplastic fluids. 2012 Plant Biol (Stuttg) pmid:21972816
Baumlova A et al. The structural basis for calcium inhibition of lipid kinase PI4K IIalpha and comparison with the apo state. 2016 Physiol Res pmid:27539108
Furse S et al. Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity. 2015 Org. Biomol. Chem. pmid:25515724
Carloni V et al. Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. 2004 Oncogene pmid:14676841
Li L et al. A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca signals and confers salt tolerance to rice. 2017 New Phytol. pmid:28157263
Van Rooijen LA and Agranoff BW Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics. 1985 Neurochem. Res. pmid:2997640
Park J et al. Deleterious effects of soluble amyloid-β oligomers on multiple steps of synaptic vesicle trafficking. 2013 Neurobiol. Dis. pmid:23523634
McNamara CW et al. Targeting Plasmodium PI(4)K to eliminate malaria. 2013 Nature pmid:24284631
Whitman M et al. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. 1988 Nature pmid:2833705
He K et al. Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. 2017 Nature pmid:29236694
Ketel K et al. A phosphoinositide conversion mechanism for exit from endosomes. 2016 Nature pmid:26760201
D'Angelo G et al. Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi. 2013 Nature pmid:23913272
D'Angelo G et al. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. 2007 Nature pmid:17687330
Rameh LE et al. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. 1997 Nature pmid:9367159
Hanada K et al. Molecular machinery for non-vesicular trafficking of ceramide. 2003 Nature pmid:14685229
Fukami K et al. Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function. 1992 Nature pmid:1326084
Niu Y et al. PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network. 2013 Nat. Cell Biol. pmid:23524952
Sun Y and Drubin DG Pik1-ing clathrin adaptors. 2012 Nat. Cell Biol. pmid:22344031
Roth M New candidates for vesicle coat proteins. 2004 Nat. Cell Biol. pmid:15122263
Godi A et al. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. 2004 Nat. Cell Biol. pmid:15107860