| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Zhainazarov AB and Ache BW | Effects of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate on a Na+-gated nonselective cation channel. | 1999 | J. Neurosci. | pmid:10191310 |
| Basu SS et al. | A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. | 1999 | J. Biol. Chem. | pmid:10196199 |
| Stock SD et al. | SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production. | 1999 | J. Biol. Chem. | pmid:10224046 |
| Kim D and Bang H | Modulation of rat atrial G protein-coupled K+ channel function by phospholipids. | 1999 | J. Physiol. (Lond.) | pmid:10226149 |
| Neri LM et al. | Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10362505 |
| Rivas MP et al. | Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. | 1999 | Mol. Biol. Cell | pmid:10397762 |
| Sorensen SD et al. | Inhibition of beta(2)-adrenergic and muscarinic cholinergic receptor endocytosis after depletion of phosphatidylinositol bisphosphate. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10411568 |
| RÃpová D et al. | Phosphoinositide signalling system in platelets of schizophrenic patients and the effect of neuroleptic therapy. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509868 |
| Hama H et al. | Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. | 1999 | J. Biol. Chem. | pmid:10567405 |
| Gonzalez-Agosti C et al. | Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF. | 1999 | J. Biol. Chem. | pmid:10567424 |
| Kurosawa M et al. | Formation of phosphatidylinositol-4-phosphate in human peripheral blood eosinophils. | 1993 | Clin. Exp. Allergy | pmid:10779308 |
| Arcaro A et al. | Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. | 2000 | Mol. Cell. Biol. | pmid:10805725 |
| Baukrowitz T and Fakler B | K(ATP) channels: linker between phospholipid metabolism and excitability. | 2000 | Biochem. Pharmacol. | pmid:10930527 |
| Tharmapathy P et al. | The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombin. | 2000 | Biochem. Pharmacol. | pmid:11008120 |
| Frohman MA et al. | Regulation of phospholipase D1 activity by Rho GTPases. | 2000 | Meth. Enzymol. | pmid:11036603 |
| Hsu FF and Turk J | Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry: a mechanistic study. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:11073262 |
| Carricaburu V and Fournier B | Phosphoinositide fatty acids regulate phosphatidylinositol 5-kinase, phospholipase C and protein kinase C activities. | 2001 | Eur. J. Biochem. | pmid:11231275 |
| Suer S et al. | Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites. | 2001 | Eur. J. Biochem. | pmid:11277933 |
| Huang Z et al. | Regulation of type II phosphatidylinositol phosphate kinase by tyrosine phosphorylation in bovine rod outer segments. | 2001 | Biochemistry | pmid:11294622 |
| Monks DE et al. | Hyperosmotic stress induces the rapid phosphorylation of a soybean phosphatidylinositol transfer protein homolog through activation of the protein kinases SPK1 and SPK2. | 2001 | Plant Cell | pmid:11340192 |
| Simonsen A et al. | The role of phosphoinositides in membrane transport. | 2001 | Curr. Opin. Cell Biol. | pmid:11454456 |
| Foti M et al. | Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. | 2001 | Mol. Biol. Cell | pmid:11514624 |
| Zhao X et al. | Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells. | 2001 | J. Biol. Chem. | pmid:11526106 |
| Ago T et al. | The PX domain as a novel phosphoinositide- binding module. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11563857 |
| Kim YW et al. | Arabidopsis dynamin-like 2 that binds specifically to phosphatidylinositol 4-phosphate assembles into a high-molecular weight complex in vivo and in vitro. | 2001 | Plant Physiol. | pmid:11706203 |
| Meijer HJ et al. | Identification of a new polyphosphoinositide in plants, phosphatidylinositol 5-monophosphate (PtdIns5P), and its accumulation upon osmotic stress. | 2001 | Biochem. J. | pmid:11716778 |
| Konrad G et al. | Retention of the yeast Sac1p phosphatase in the endoplasmic reticulum causes distinct changes in cellular phosphoinositide levels and stimulates microsomal ATP transport. | 2002 | J. Biol. Chem. | pmid:11792713 |
| Ishiyama N et al. | The effects of deimination of myelin basic protein on structures formed by its interaction with phosphoinositide-containing lipid monolayers. | 2001 | J. Struct. Biol. | pmid:11858705 |
| Audhya A and Emr SD | Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. | 2002 | Dev. Cell | pmid:12015967 |
| Nasuhoglu C et al. | Modulation of cardiac PIP2 by cardioactive hormones and other physiologically relevant interventions. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:12055091 |
| Jung JY et al. | Phosphatidylinositol 3- and 4-phosphate are required for normal stomatal movements. | 2002 | Plant Cell | pmid:12368494 |
| De Matteis M et al. | Phosphoinositides and the golgi complex. | 2002 | Curr. Opin. Cell Biol. | pmid:12383794 |
| Wu B et al. | Phosphatidylinositol and PI-4-monophosphate recover amyloid beta protein-induced inhibition of Cl- -ATPase activity. | 2002 | Life Sci. | pmid:12467886 |
| Rajebhosale M et al. | Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells. | 2003 | J. Biol. Chem. | pmid:12471042 |
| Hill CM et al. | Terminal deletion mutants of myelin basic protein: new insights into self-association and phospholipid interactions. | 2003 | Micron | pmid:12694855 |
| Wang YJ et al. | Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. | 2003 | Cell | pmid:12914695 |
| Waugh MG et al. | Identification and characterization of differentially active pools of type IIalpha phosphatidylinositol 4-kinase activity in unstimulated A431 cells. | 2003 | Biochem. J. | pmid:12954081 |
| Roldan ER and Harrison RA | The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols. | 1992 | Biochem. J. | pmid:1311174 |
| Khalaf LJ and Laychock SG | Phosphatidylinositol availability and polyphosphoinositide synthesis in pancreatic islet cell membranes. | 1992 | Biochem. Pharmacol. | pmid:1314058 |
| Furuhashi K et al. | Inositol phospholipid-induced suppression of F-actin-gelating activity of smooth muscle filamin. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1317169 |
| Janmey PA et al. | Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin. | 1992 | J. Biol. Chem. | pmid:1318302 |
| Katakami Y et al. | Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex. | 1992 | Biochim. Biophys. Acta | pmid:1322701 |
| Fukami K et al. | Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function. | 1992 | Nature | pmid:1326084 |
| Santi P et al. | Changes in polyphosphoinositide levels in rat liver nuclei in response to prolactin, a known hepatic mitogen. | 1992 | Cell. Signal. | pmid:1329898 |
| Divecha N et al. | Purification and characterization of phosphatidylinositol 4-phosphate 5-kinases. | 1992 | Biochem. J. | pmid:1334412 |
| Celadon M et al. | Influence of chronic ethanol consumption on the inositol phospholipid fatty acid composition of human peripheral blood lymphocytes. | Immunol. Lett. | pmid:1336764 | |
| Bordin L et al. | Tyrosine-protein kinase inhibition in human erythrocytes by polyphosphoinositides (PIP and PIP2). | 1992 | Biochem. Biophys. Res. Commun. | pmid:1382423 |
| Fung BM | New angles for NMR studies of biological molecules. | 2003 | Biophys. J. | pmid:14645039 |
| Carloni V et al. | Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells. | 2004 | Oncogene | pmid:14676841 |
| Hanada K et al. | Molecular machinery for non-vesicular trafficking of ceramide. | 2003 | Nature | pmid:14685229 |
| Wild AC et al. | The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate. | 2004 | J. Biol. Chem. | pmid:14766750 |
| Godi A et al. | FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. | 2004 | Nat. Cell Biol. | pmid:15107860 |
| Roth M | New candidates for vesicle coat proteins. | 2004 | Nat. Cell Biol. | pmid:15122263 |
| Roy A and Levine TP | Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. | 2004 | J. Biol. Chem. | pmid:15271978 |
| Seifert JP et al. | RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism. | 2004 | J. Biol. Chem. | pmid:15322077 |
| Shin HW and Nakayama K | Dual control of membrane targeting by PtdIns(4)P and ARF. | 2004 | Trends Biochem. Sci. | pmid:15450602 |
| Nilssen LS et al. | Sustained diacylglycerol accumulation resulting from prolonged G protein-coupled receptor agonist-induced phosphoinositide breakdown in hepatocytes. | 2005 | J. Cell. Biochem. | pmid:15526278 |
| Fernandis AZ et al. | A type II phosphatidylinositol 4-kinase associates with T cell receptor zeta chain in Con A stimulated splenic lymphocytes through tyrosyl phosphorylation-dependent mechanisms. | 2005 | Mol. Immunol. | pmid:15607814 |
| Tahirovic S et al. | Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase. | 2005 | Traffic | pmid:15634212 |
| Weixel KM et al. | Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases. | 2005 | J. Biol. Chem. | pmid:15634669 |
| Balla A et al. | A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1. | 2005 | Mol. Biol. Cell | pmid:15635101 |
| Faulhammer F et al. | Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p. | 2005 | J. Cell Biol. | pmid:15657391 |
| Zheng Q et al. | Neuronal calcium sensor-1 facilitates neuronal exocytosis through phosphatidylinositol 4-kinase. | 2005 | J. Neurochem. | pmid:15659215 |
| Flesch FM et al. | Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain. | 2005 | Biochem. J. | pmid:15755258 |
| Perera IY et al. | Characterization and comparative analysis of Arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in Arabidopsis and human phosphatidylinositol phosphate kinases. | 2005 | FEBS Lett. | pmid:15949803 |
| Pendaries C et al. | Emerging roles of phosphatidylinositol monophosphates in cellular signaling and trafficking. | 2005 | Adv. Enzyme Regul. | pmid:16023705 |
| Olas B et al. | Resveratrol inhibits polyphosphoinositide metabolism in activated platelets. | 2005 | Biochim. Biophys. Acta | pmid:16051184 |
| Waselle L et al. | Role of phosphoinositide signaling in the control of insulin exocytosis. | 2005 | Mol. Endocrinol. | pmid:16081518 |
| Vieira OV et al. | FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. | 2005 | J. Cell Biol. | pmid:16103222 |
| Ungewickell A et al. | The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16365287 |
| Tusupov OK et al. | Proteolytic fragment of protein kinase C (kinase M) phosphorylates in vitro phosphatidylinositol-4-phosphate. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1645534 |
| Martelli AM et al. | Mitogen-stimulated events in nuclei of Swiss 3T3 cells. Evidence for a direct link between changes of inositol lipids, protein kinase C requirement and the onset of DNA synthesis. | 1991 | FEBS Lett. | pmid:1646120 |
| Baust T et al. | Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16492770 |
| Conway BR et al. | Comparative effects of epidermal growth factor and carbachol on phosphoinositide synthesis and breakdown in pancreatic acinar cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1650199 |
| de Wolf FA et al. | Characterization of the interaction of doxorubicin with (poly)phosphoinositides in model systems. Evidence for specific interaction with phosphatidylinositol-monophosphate and -diphosphate. | 1991 | FEBS Lett. | pmid:1652476 |
| Chauhan A et al. | Interaction of protein kinase C with phosphoinositides. | 1991 | Arch. Biochem. Biophys. | pmid:1654811 |
| Walsh JP et al. | Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1656463 |
| Gascard P et al. | Asymmetric distribution of phosphoinositides and phosphatidic acid in the human erythrocyte membrane. | 1991 | Biochim. Biophys. Acta | pmid:1657164 |
| Kellerer M et al. | Stimulation of phospholipase C activity by insulin is mediated by both isotypes of the human insulin receptor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1661583 |
| Andersen JF and Ribeiro JM | A secreted salivary inositol polyphosphate 5-phosphatase from a blood-feeding insect: allosteric activation by soluble phosphoinositides and phosphatidylserine. | 2006 | Biochemistry | pmid:16634626 |
| Weber SS et al. | Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. | 2006 | PLoS Pathog. | pmid:16710455 |
| Yamashita S et al. | PI4P-signaling pathway for the synthesis of a nascent membrane structure in selective autophagy. | 2006 | J. Cell Biol. | pmid:16754956 |
| Ferchmin PA | Are polyamines modulators of the CNS? | 1991 | Ann. N. Y. Acad. Sci. | pmid:1679312 |
| Balla A and Balla T | Phosphatidylinositol 4-kinases: old enzymes with emerging functions. | 2006 | Trends Cell Biol. | pmid:16793271 |
| Jarquin-Pardo M et al. | Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate. | 2007 | J. Cell. Biochem. | pmid:16888807 |
| Hilbi H | Modulation of phosphoinositide metabolism by pathogenic bacteria. | 2006 | Cell. Microbiol. | pmid:16939534 |
| Cameroni E et al. | Phosphatidylinositol 4-phosphate is required for translation initiation in Saccharomyces cerevisiae. | 2006 | J. Biol. Chem. | pmid:17005563 |
| Shiozawa K et al. | The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97. | 2006 | FEBS J. | pmid:17018057 |
| Jeynov B et al. | Phosphoinositide synthesis and degradation in isolated rat liver peroxisomes. | 2006 | FEBS Lett. | pmid:17045591 |
| Blumental-Perry A et al. | Phosphatidylinositol 4-phosphate formation at ER exit sites regulates ER export. | 2006 | Dev. Cell | pmid:17084359 |
| Jeganathan S and Lee JM | Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation. | 2007 | J. Biol. Chem. | pmid:17088255 |
| Beck Z et al. | Calcium modulation of monoclonal antibody binding to phosphatidylinositol phosphate. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17257584 |
| König S et al. | Stress-inducible and constitutive phosphoinositide pools have distinctive fatty acid patterns in Arabidopsis thaliana. | 2007 | FASEB J. | pmid:17327357 |
| Posada V et al. | Maximal Ca2+i stimulation of cardiac Na+/Ca2+ exchange requires simultaneous alkalinization and binding of PtdIns-4,5-P2 to the exchanger. | 2007 | Biol. Chem. | pmid:17338635 |
| Wang J et al. | PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. | 2007 | Mol. Biol. Cell | pmid:17494868 |
| Stahelin RV et al. | Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity. | 2007 | J. Biol. Chem. | pmid:17581820 |
| Vorwerk S et al. | EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana. | 2007 | BMC Plant Biol. | pmid:17612410 |
| D'Angelo G et al. | Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. | 2007 | Nature | pmid:17687330 |
| Fairn GD et al. | The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17881569 |
phosphatidylinositol-4-phosphate
phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phosphatidylinositol-4-phosphate?
phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with phosphatidylinositol-4-phosphate
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phosphatidylinositol-4-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with phosphatidylinositol-4-phosphate?
There are no associated biomedical information in the current reference collection.