phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
pmid:
Kirk CJ et al. Hormone-mediated inositol lipid breakdown in hepatocytes and WRK1 cells: relationship to receptor function. Biochimie pmid:2866800
Tan J and Brill JA Cinderella story: PI4P goes from precursor to key signaling molecule. Crit. Rev. Biochem. Mol. Biol. pmid:24219382
Deli D et al. Deficiency in lysosomal enzyme secretion is associated with upregulation of phosphatidylinositol 4-phosphate in tetrahymena. J. Eukaryot. Microbiol. pmid:18681848
Celadon M et al. Influence of chronic ethanol consumption on the inositol phospholipid fatty acid composition of human peripheral blood lymphocytes. Immunol. Lett. pmid:1336764
Downes P and Michell RH Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function. 1982 Cell Calcium pmid:6297743
Volpi M et al. Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils. 1983 Biochem. Biophys. Res. Commun. pmid:6303343
Creba JA et al. Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones. 1983 Biochem. J. pmid:6309153
Farkas G et al. Cyclic AMP-dependent protein kinase stimulates the phosphorylation of phosphatidylinositol to phosphatidylinositol-4-monophosphate in a plasma membrane preparation from pig granulocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6095827
de Chaffoy de Courcelles D et al. 1-Oleoyl-2-acetyl-glycerol (OAG) stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1984 Biochem. Biophys. Res. Commun. pmid:6091634
Graff G et al. Possible regulation of phospholipase C activity in human platelets by phosphatidylinositol 4',5'-bisphosphate. 1984 Arch. Biochem. Biophys. pmid:6320736
Deshmukh DS et al. Mutual stimulation by phosphatidylinositol-4-phosphate and myelin basic protein of their phosphorylation by the kinases solubilized from rat brain myelin. 1984 Life Sci. pmid:6198580
Kolesnick RN and Gershengorn MC Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells. 1984 J. Biol. Chem. pmid:6086636
Smith CD and Wells WW Characterization of a phosphatidylinositol 4-phosphate-specific phosphomonoesterase in rat liver nuclear envelopes. 1984 Arch. Biochem. Biophys. pmid:6097190
Enyedi A et al. Cyclic AMP-dependent protein kinase and Ca2+-calmodulin stimulate the formation of polyphosphoinositides in a sarcoplasmic reticulum preparation of rabbit heart. 1984 FEBS Lett. pmid:6092135
Seyfred MA and Wells WW Subcellular incorporation of 32P into phosphoinositides and other phospholipids in isolated hepatocytes. 1984 J. Biol. Chem. pmid:6330069
Wassef NM et al. Suppression of phagocytic function and phospholipid metabolism in macrophages by phosphatidylinositol liposomes. 1984 Proc. Natl. Acad. Sci. U.S.A. pmid:6326135
Tooke NE et al. Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour. 1984 Biochem. J. pmid:6331389
Vickers JD et al. Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin. 1984 Biochem. J. pmid:6326756
Hawkins PT et al. Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes. 1984 Biochem. J. pmid:6326746
Halenda SP and Feinstein MB Phorbol myristate acetate stimulates formation of phosphatidyl inositol 4-phosphate and phosphatidyl inositol 4,5-bisphosphate in human platelets. 1984 Biochem. Biophys. Res. Commun. pmid:6093804
Ishizuka Y et al. Polyphosphoinositide turnover in rat mast cells stimulated by antigen: rapid and preferential breakdown of phosphatidylinositol 4-phosphate (DPI). 1984 Biochem. Biophys. Res. Commun. pmid:6091652
Okano Y et al. Inhibitory action of phorbol myristate acetate on histamine secretion and polyphosphoinositide turnover induced by compound 48/80 in mast cells. 1985 Biochem. Biophys. Res. Commun. pmid:2415122
Raben DM and Cunningham DD Effects of EGF and thrombin on inositol-containing phospholipids of cultured fibroblasts: stimulation of phosphatidylinositol synthesis by thrombin but not EGF. 1985 J. Cell. Physiol. pmid:2999166
Carney DH et al. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. 1985 Cell pmid:2992800
Tallant EA and Wallace RW Calmodulin antagonists elevate the levels of 32P-labeled polyphosphoinositides in human platelets. 1985 Biochem. Biophys. Res. Commun. pmid:2994657
Knowles AF and Lawrence CM Enzymatic synthesis and hydrolysis of [32P]phosphatidylinositol phosphate. 1985 Biochem. Biophys. Res. Commun. pmid:2988548
Holian A and Stickle DF Calcium regulation of phosphatidyl inositol turnover in macrophage activation by formyl peptides. 1985 J. Cell. Physiol. pmid:2982888
van Dongen CJ et al. Microdetermination of phosphoinositides in a single extract. 1985 Anal. Biochem. pmid:2984954
Quist E Ca2+-stimulated phospholipid phosphoesterase activities in rabbit erythrocyte membranes. 1985 Arch. Biochem. Biophys. pmid:2981504
Van Rooijen LA and Agranoff BW Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics. 1985 Neurochem. Res. pmid:2997640
Smith CD et al. Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. 1985 J. Biol. Chem. pmid:2987206
Watson SP and Lapetina EG 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2986126
Taylor D et al. Insulin and epidermal growth factor do not affect phosphoinositide metabolism in rat liver plasma membranes and hepatocytes. 1985 J. Biol. Chem. pmid:2982801
Van Rooijen LA et al. Tetraenoic species are conserved in muscarinically enhanced inositide turnover. 1985 J. Neurochem. pmid:2981288
Wilson DB et al. Phosphoinositide interconversion in thrombin-stimulated human platelets. 1985 J. Biol. Chem. pmid:2981829
Volpi M et al. Phorbol 12-myristate, 13-acetate potentiates the action of the calcium ionophore in stimulating arachidonic acid release and production of phosphatidic acid in rabbit neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:2986620
Cockcroft S et al. Breakdown and synthesis of polyphosphoinositides in fMetLeuPhe-stimulated neutrophils. 1985 FEBS Lett. pmid:2982660
Le Peuch Cj et al. Parthenogenetic activation decreases the polyphosphoinositide content of frog eggs. 1985 FEBS Lett. pmid:2991011
Berti-Mattera LN et al. Insulin reverses enhanced incorporation of 32P into polyphosphoinositides in peripheral nerve of the streptozotocin diabetic rat. 1986 J. Neurochem. pmid:3021909
Tysnes OB et al. Phosphate turnover of phosphatidylinositol in resting and thrombin-stimulated platelets. 1986 Biochim. Biophys. Acta pmid:3022825
de Chaffoy de Courcelles D et al. Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1986 FEBS Lett. pmid:2417883
Holian A Leukotriene B4 stimulation of phosphatidylinositol turnover in macrophages and inhibition by pertussis toxin. 1986 FEBS Lett. pmid:3011502
Imai A et al. Differential regulation by phosphatidylinositol 4,5-bisphosphate of pituitary plasma-membrane and cytosolic phosphoinositide kinases. 1986 Biochem. J. pmid:3028374
Urumow T and Wieland OH Stimulation of phosphatidylinositol 4-phosphate phosphorylation in human placenta membranes by GTP gamma S. 1986 FEBS Lett. pmid:3021533
Palmer S et al. The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes. 1986 Biochem. J. pmid:3026353
Vickers JD and Mustard JF The phosphoinositides exist in multiple metabolic pools in rabbit platelets. 1986 Biochem. J. pmid:3026351
Philp NJ and Grollman EF Thyrotropin and norepinephrine stimulate the metabolism of phosphoinositides in FRTL-5 thyroid cells. 1986 FEBS Lett. pmid:3013684
Hidalgo C et al. Phosphorylation of phosphatidylinositol by transverse tubule vesicles and its possible role in excitation-contraction coupling. 1986 FEBS Lett. pmid:3013681
Sale GJ et al. Characterization of phosphatidylinositol kinase activity associated with the insulin receptor. 1986 Eur. J. Biochem. pmid:3007126