phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Banerjee S et al. Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein. 2018 PLoS Pathog. pmid:29782554
Ahaley SS Synaptojanin regulates Hedgehog signalling by modulating phosphatidylinositol 4-phosphate levels. 2018 J. Biosci. pmid:30541947
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Zhang Q et al. Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth. 2018 Plant Cell Physiol. pmid:30107538
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Del Bel LM et al. The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing eye. 2018 Development pmid:29752385
Lundquist MR et al. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. 2018 Mol. Cell pmid:29727621
Oh HS et al. Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides. 2018 PLoS Pathog. pmid:29702686
Melia CE et al. The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles. 2018 MBio pmid:29666283
Iwama R et al. Osh6p, a homologue of the oxysterol-binding protein, is involved in production of functional cytochrome P450 belonging to CYP52 family in n-alkane-assimilating yeast Yarrowia lipolytica. 2018 Biochem. Biophys. Res. Commun. pmid:29621549
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Madukwe JC et al. G protein βγ subunits directly interact with and activate phospholipase Cϵ. 2018 J. Biol. Chem. pmid:29535186
Minogue S The Many Roles of Type II Phosphatidylinositol 4-Kinases in Membrane Trafficking: New Tricks for Old Dogs. 2018 Bioessays pmid:29280156
Du X et al. The role of oxysterol-binding protein and its related proteins in cancer. 2018 Semin. Cell Dev. Biol. pmid:28733164
Mukherjee P et al. Lipid and membrane recognition by the oxysterol binding protein and its phosphomimetic mutant using dual polarization interferometry. 2018 Biochim Biophys Acta Biomembr pmid:29879417
He K et al. Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. 2017 Nature pmid:29236694
Allgood SC et al. Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner. 2017 Front Cell Infect Microbiol pmid:28944216
Gulyás G et al. Plasma membrane phosphatidylinositol 4-phosphate and 4,5-bisphosphate determine the distribution and function of K-Ras4B but not H-Ras proteins. 2017 J. Biol. Chem. pmid:28939768
Anitei M et al. Spatiotemporal Control of Lipid Conversion, Actin-Based Mechanical Forces, and Curvature Sensors during Clathrin/AP-1-Coated Vesicle Biogenesis. 2017 Cell Rep pmid:28854360
Zhang JQ et al. Persistency of Enlarged Autolysosomes Underscores Nanoparticle-Induced Autophagy in Hepatocytes. 2017 Small pmid:27925395
Khadka B and Gupta RS Identification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role. 2017 Proteins pmid:28407364
Acosta-Andrade C et al. Polyamine-RNA-membrane interactions: From the past to the future in biology. 2017 Colloids Surf B Biointerfaces pmid:28456048
Mesmin B et al. Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP. 2017 EMBO J. pmid:28978670
Banerjee S and Kane PM Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast. 2017 Mol. Biol. Cell pmid:28720663
Prashek J et al. Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain. 2017 J. Biol. Chem. pmid:28652409
Yoshida A et al. Segregation of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate into distinct microdomains on the endosome membrane. 2017 Biochim Biophys Acta Biomembr pmid:28648675
Hanes CM et al. Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate. 2017 J. Immunol. pmid:28539432
Manik MK et al. Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction. 2017 Structure pmid:28319008
Azouaoui H et al. High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions. 2017 J. Biol. Chem. pmid:28302728
Wu F et al. Hedgehog Signaling: From Basic Biology to Cancer Therapy. 2017 Cell Chem Biol pmid:28286127
Altan-Bonnet N Lipid Tales of Viral Replication and Transmission. 2017 Trends Cell Biol. pmid:27838086
Rizzo R et al. GOLPH3 and oncogenesis: What is the molecular link? 2017 Tissue Cell pmid:27378035
Ghai R et al. ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P ) and regulate its level at the plasma membrane. 2017 Nat Commun pmid:28970484
Zhao K and Ridgway ND Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System. 2017 Cell Rep pmid:28564600
Charman M et al. Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1. 2017 Traffic pmid:28471037
Sayyed SG et al. The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins. 2017 Kidney Int. pmid:28302370
Li L et al. A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca signals and confers salt tolerance to rice. 2017 New Phytol. pmid:28157263
Sampaio LS et al. Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies? 2017 Lipids Health Dis pmid:29246161
Hirama T et al. Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane. 2017 J. Biol. Chem. pmid:28698382
De Craene JO et al. Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways. 2017 Int J Mol Sci pmid:28294977
Bone LN et al. The acyltransferase LYCAT controls specific phosphoinositides and related membrane traffic. 2017 Mol. Biol. Cell pmid:28035047
Levin R et al. Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis. 2017 Mol. Biol. Cell pmid:28035045
Zhang J et al. Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy. 2016 Int. J. Biochem. Cell Biol. pmid:26589722
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Alli-Balogun GO et al. Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype. 2016 Mol. Biol. Cell pmid:27798239
Xing M et al. GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. 2016 Mol. Biol. Cell pmid:27708138
Baumlova A et al. The structural basis for calcium inhibition of lipid kinase PI4K IIalpha and comparison with the apo state. 2016 Physiol Res pmid:27539108
Jin MW et al. [Effect of phosphoinositide 4-phosphate on invasion and migration of human glioma U87 cells]. 2016 Zhongguo Dang Dai Er Ke Za Zhi pmid:27530799
Dong R et al. Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. 2016 Cell pmid:27419871