phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Berryman S et al. Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases. 2016 J. Gen. Virol. pmid:27093462
Badheka D et al. Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel. 2015 J. Gen. Physiol. pmid:26123195
Kim DI et al. Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels. 2015 J. Gen. Physiol. pmid:25964431
Deli D et al. Deficiency in lysosomal enzyme secretion is associated with upregulation of phosphatidylinositol 4-phosphate in tetrahymena. J. Eukaryot. Microbiol. pmid:18681848
English D et al. Relationship of phosphatidylinositol bisphosphate hydrolysis to calcium mobilization and functional activation in fluoride-treated neutrophils. 1987 J. Clin. Invest. pmid:3036911
Klinkenberg D et al. A cascade of ER exit site assembly that is regulated by p125A and lipid signals. 2014 J. Cell. Sci. pmid:24522181
Quilty D et al. Arf activation at the Golgi is modulated by feed-forward stimulation of the exchange factor GBF1. 2014 J. Cell. Sci. pmid:24213530
Han WQ et al. Lysosome fusion to the cell membrane is mediated by the dysferlin C2A domain in coronary arterial endothelial cells. 2012 J. Cell. Sci. pmid:22349696
Dumaresq-Doiron K et al. The phosphatidylinositol 4-kinase PI4KIIIalpha is required for the recruitment of GBF1 to Golgi membranes. 2010 J. Cell. Sci. pmid:20530568
Wuttke A et al. Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated beta-cells. 2010 J. Cell. Sci. pmid:20375060
Carvou N et al. Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum. 2010 J. Cell. Sci. pmid:20332109
Chan MW et al. FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actin. 2009 J. Cell. Sci. pmid:19596799
D'Angelo G et al. The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2. 2008 J. Cell. Sci. pmid:18525025
Lopes da Silva M et al. Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells. 2016 J. Cell. Sci. pmid:27068535
Kuehnel MP et al. Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen. 2009 J. Cell. Sci. pmid:19174471
Raben DM and Cunningham DD Effects of EGF and thrombin on inositol-containing phospholipids of cultured fibroblasts: stimulation of phosphatidylinositol synthesis by thrombin but not EGF. 1985 J. Cell. Physiol. pmid:2999166
Holian A and Stickle DF Calcium regulation of phosphatidyl inositol turnover in macrophage activation by formyl peptides. 1985 J. Cell. Physiol. pmid:2982888
Nilssen LS et al. Sustained diacylglycerol accumulation resulting from prolonged G protein-coupled receptor agonist-induced phosphoinositide breakdown in hepatocytes. 2005 J. Cell. Biochem. pmid:15526278
Jarquin-Pardo M et al. Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate. 2007 J. Cell. Biochem. pmid:16888807
Wood CS et al. PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking. 2009 J. Cell Biol. pmid:20026658