phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Cooke FT et al. The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae. 1998 Curr. Biol. pmid:9811604
Hollenback D and Glomset JA On the relation between a stearoyl-specific transacylase from bovine testis membranes and a copurifying acyltransferase. 1998 Biochemistry pmid:9425058
Gonzalez-Agosti C et al. Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF. 1999 J. Biol. Chem. pmid:10567424
Hama H et al. Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. 1999 J. Biol. Chem. pmid:10567405
Sorensen SD et al. Inhibition of beta(2)-adrenergic and muscarinic cholinergic receptor endocytosis after depletion of phosphatidylinositol bisphosphate. 1999 J. Pharmacol. Exp. Ther. pmid:10411568
Rivas MP et al. Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. 1999 Mol. Biol. Cell pmid:10397762
Kim D and Bang H Modulation of rat atrial G protein-coupled K+ channel function by phospholipids. 1999 J. Physiol. (Lond.) pmid:10226149
Stock SD et al. SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production. 1999 J. Biol. Chem. pmid:10224046
Basu SS et al. A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. 1999 J. Biol. Chem. pmid:10196199
Zhainazarov AB and Ache BW Effects of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate on a Na+-gated nonselective cation channel. 1999 J. Neurosci. pmid:10191310
Nagano K et al. A novel phospholipase C delta4 (PLCdelta4) splice variant as a negative regulator of PLC. 1999 J. Biol. Chem. pmid:9915823
Rípová D et al. Phosphoinositide signalling system in platelets of schizophrenic patients and the effect of neuroleptic therapy. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10509868
Neri LM et al. Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms. 1999 Biochem. Biophys. Res. Commun. pmid:10362505
Hsu FF and Turk J Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry: a mechanistic study. 2000 J. Am. Soc. Mass Spectrom. pmid:11073262
Arcaro A et al. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. 2000 Mol. Cell. Biol. pmid:10805725
Frohman MA et al. Regulation of phospholipase D1 activity by Rho GTPases. 2000 Meth. Enzymol. pmid:11036603
Tharmapathy P et al. The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombin. 2000 Biochem. Pharmacol. pmid:11008120
Baukrowitz T and Fakler B K(ATP) channels: linker between phospholipid metabolism and excitability. 2000 Biochem. Pharmacol. pmid:10930527
Ishiyama N et al. The effects of deimination of myelin basic protein on structures formed by its interaction with phosphoinositide-containing lipid monolayers. 2001 J. Struct. Biol. pmid:11858705
Ago T et al. The PX domain as a novel phosphoinositide- binding module. 2001 Biochem. Biophys. Res. Commun. pmid:11563857