phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Shulga YV et al. Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator. 2012 J. Biol. Chem. pmid:22942276
Bishé B et al. Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. 2012 J. Biol. Chem. pmid:22745132
Roy A and Levine TP Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. 2004 J. Biol. Chem. pmid:15271978
Wild AC et al. The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate. 2004 J. Biol. Chem. pmid:14766750
Stevenson JM et al. A phosphatidylinositol 4-kinase pleckstrin homology domain that binds phosphatidylinositol 4-monophosphate. 1998 J. Biol. Chem. pmid:9712908
Waugh MG et al. Phosphatidylinositol 4-phosphate synthesis in immunoisolated caveolae-like vesicles and low buoyant density non-caveolar membranes. 1998 J. Biol. Chem. pmid:9642278
Willars GB et al. Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells. 1998 J. Biol. Chem. pmid:9478953
Filtz TM et al. Purification and G protein subunit regulation of a phospholipase C-beta from Xenopus laevis oocytes. 1996 J. Biol. Chem. pmid:8940109
DebBurman SK et al. G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits. 1996 J. Biol. Chem. pmid:8798423
Molz L et al. Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. 1996 J. Biol. Chem. pmid:8662856
Bryckaert MC et al. Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation. 1989 J. Biol. Chem. pmid:2538439
Smith CD and Chang KJ Regulation of brain phosphatidylinositol-4-phosphate kinase by GTP analogues. A potential role for guanine nucleotide regulatory proteins. 1989 J. Biol. Chem. pmid:2536738
Kato H et al. Activation of phosphatidylinositol kinase and phosphatidylinositol-4-phosphate kinase by cAMP in Saccharomyces cerevisiae. 1989 J. Biol. Chem. pmid:2536734
Sahyoun NE et al. A synaptosomal protein kinase is regulated by phosphatidylinositol 4-phosphate and Mg2+. 1989 J. Biol. Chem. pmid:2536015
Fukui T et al. Purification of a phospholipase C from rat liver cytosol that acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate. 1988 J. Biol. Chem. pmid:2846577
Smith CD et al. Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. 1985 J. Biol. Chem. pmid:2987206
Taylor D et al. Insulin and epidermal growth factor do not affect phosphoinositide metabolism in rat liver plasma membranes and hepatocytes. 1985 J. Biol. Chem. pmid:2982801
Wilson DB et al. Phosphoinositide interconversion in thrombin-stimulated human platelets. 1985 J. Biol. Chem. pmid:2981829
Goto A et al. Oxysterol-binding Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol 4-Phosphate Pools. 2016 J. Biol. Chem. pmid:26601944
Charman M et al. Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival. 2014 J. Biol. Chem. pmid:24742681