phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Bojjireddy N et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. 2014 J. Biol. Chem. pmid:24415756
Lukacs V et al. Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity. 2013 J. Biol. Chem. pmid:24158445
Zhou X et al. Auto-inhibition of Drs2p, a yeast phospholipid flippase, by its carboxyl-terminal tail. 2013 J. Biol. Chem. pmid:24045945
Jacquot A et al. Phosphatidylserine stimulation of Drs2p·Cdc50p lipid translocase dephosphorylation is controlled by phosphatidylinositol-4-phosphate. 2012 J. Biol. Chem. pmid:22351780
Qin Y et al. Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl. 2009 J. Biol. Chem. pmid:19561074
Korzeniowski MK et al. Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. 2009 J. Biol. Chem. pmid:19483082
Konrad G et al. Retention of the yeast Sac1p phosphatase in the endoplasmic reticulum causes distinct changes in cellular phosphoinositide levels and stimulates microsomal ATP transport. 2002 J. Biol. Chem. pmid:11792713
Zhao X et al. Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells. 2001 J. Biol. Chem. pmid:11526106
Kolesnick RN and Gershengorn MC Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells. 1984 J. Biol. Chem. pmid:6086636
Molz L et al. Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. 1996 J. Biol. Chem. pmid:8662856
Starling AP et al. Phosphatidylinositol 4-phosphate increases the rate of dephosphorylation of the phosphorylated Ca(2+)-ATPase. 1995 J. Biol. Chem. pmid:7782308
Einspahr KJ et al. Rapid changes in polyphosphoinositide metabolism associated with the response of Dunaliella salina to hypoosmotic shock. 1988 J. Biol. Chem. pmid:2833516
Verhoeven AJ et al. Stimulation of phosphate uptake in human platelets by thrombin and collagen. Changes in specific 32P labeling of metabolic ATP and polyphosphoinositides. 1987 J. Biol. Chem. pmid:3034877
Enyedi A et al. The maximal velocity and the calcium affinity of the red cell calcium pump may be regulated independently. 1987 J. Biol. Chem. pmid:3032968
Hirama T et al. Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane. 2017 J. Biol. Chem. pmid:28698382
Wilson DB et al. Phosphoinositide interconversion in thrombin-stimulated human platelets. 1985 J. Biol. Chem. pmid:2981829
Seyfred MA and Wells WW Subcellular incorporation of 32P into phosphoinositides and other phospholipids in isolated hepatocytes. 1984 J. Biol. Chem. pmid:6330069
Ohnuma M and Mabuchi I 45K actin filament-severing protein from sea urchin eggs: interaction with phosphatidylinositol-4,5-bisphosphate. 1993 J. Biochem. pmid:8113226
Hsu FF and Turk J Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry: a mechanistic study. 2000 J. Am. Soc. Mass Spectrom. pmid:11073262
Leber W et al. A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum. 2009 Int. J. Parasitol. pmid:19171150