| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bishé B et al. | Phosphoinositides in the hepatitis C virus life cycle. | 2012 | Viruses | pmid:23202467 |
| Nakatsu F et al. | PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. | 2012 | J. Cell Biol. | pmid:23229899 |
| Ng MM et al. | GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. | 2013 | Mol. Biol. Cell | pmid:23345592 |
| Forrest S et al. | Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis. | 2013 | Hum. Mol. Genet. | pmid:23492670 |
| Park J et al. | Deleterious effects of soluble amyloid-β oligomers on multiple steps of synaptic vesicle trafficking. | 2013 | Neurobiol. Dis. | pmid:23523634 |
| Niu Y et al. | PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network. | 2013 | Nat. Cell Biol. | pmid:23524952 |
| Zhang L et al. | Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. | 2013 | Cell | pmid:23540699 |
| Bayot A et al. | Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies. | 2013 | Hum. Mol. Genet. | pmid:23552101 |
| Clayton EL et al. | Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. | 2013 | Prog. Lipid Res. | pmid:23608234 |
| Munnik T | Analysis of D3-,4-,5-phosphorylated phosphoinositides using HPLC. | 2013 | Methods Mol. Biol. | pmid:23681519 |
| De Matteis MA et al. | Phosphatidylinositol-4-phosphate: the Golgi and beyond. | 2013 | Bioessays | pmid:23712958 |
| Lenoir M and Overduin M | PtdIns(4)P signalling and recognition systems. | 2013 | Adv. Exp. Med. Biol. | pmid:23775691 |
| Tong J et al. | Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins. | 2013 | Structure | pmid:23791945 |
| Levine TP and Menon AK | A protein pair with PIPs inside. | 2013 | Structure | pmid:23823324 |
| Tavoosi N et al. | Factor VII and protein C are phosphatidic acid-binding proteins. | 2013 | Biochemistry | pmid:23879866 |
| D'Angelo G et al. | Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi. | 2013 | Nature | pmid:23913272 |
| Zhou X et al. | Auto-inhibition of Drs2p, a yeast phospholipid flippase, by its carboxyl-terminal tail. | 2013 | J. Biol. Chem. | pmid:24045945 |
| Okano Y et al. | Inhibitory action of phorbol myristate acetate on histamine secretion and polyphosphoinositide turnover induced by compound 48/80 in mast cells. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2415122 |
| Lukacs V et al. | Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity. | 2013 | J. Biol. Chem. | pmid:24158445 |
| de Chaffoy de Courcelles D et al. | Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4-phosphate in intact human platelets. | 1986 | FEBS Lett. | pmid:2417883 |
| Wieffer M et al. | PI4K2β/AP-1-based TGN-endosomal sorting regulates Wnt signaling. | 2013 | Curr. Biol. | pmid:24206846 |
| Mesmin B et al. | A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP. | 2013 | Cell | pmid:24209621 |
| Quilty D et al. | Arf activation at the Golgi is modulated by feed-forward stimulation of the exchange factor GBF1. | 2014 | J. Cell. Sci. | pmid:24213530 |
| Tan J and Brill JA | Cinderella story: PI4P goes from precursor to key signaling molecule. | Crit. Rev. Biochem. Mol. Biol. | pmid:24219382 | |
| Stalder D et al. | Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24248333 |
| McNamara CW et al. | Targeting Plasmodium PI(4)K to eliminate malaria. | 2013 | Nature | pmid:24284631 |
| Zhou Y et al. | A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24326072 |
| Pike LJ and Eakes AT | Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells. | 1987 | J. Biol. Chem. | pmid:2433285 |
| Waring MJ et al. | Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation. | 2014 | Chem. Commun. (Camb.) | pmid:24366037 |
| Bojjireddy N et al. | Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. | 2014 | J. Biol. Chem. | pmid:24415756 |
| Liu Y et al. | Interaction of Fapp1 with Arf1 and PI4P at a membrane surface: an example of coincidence detection. | 2014 | Structure | pmid:24462251 |
| Wang H et al. | Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking. | 2014 | Gastroenterology | pmid:24512803 |
| Klinkenberg D et al. | A cascade of ER exit site assembly that is regulated by p125A and lipid signals. | 2014 | J. Cell. Sci. | pmid:24522181 |
| Del Campo CM et al. | Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. | 2014 | Structure | pmid:24530282 |
| Lo TN et al. | Cardiotoxin from cobra venom increases the level of phosphatidylinositol 4-monophosphate and phosphatidylinositol kinase activity in two cell lines. | 1988 | Biochim. Biophys. Acta | pmid:2453219 |
| Li H et al. | Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment. | 2014 | J. Virol. | pmid:24623438 |
| Ishikawa-Sasaki K et al. | A complex comprising phosphatidylinositol 4-kinase IIIβ, ACBD3, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is critical for formation of the viral replication complex. | 2014 | J. Virol. | pmid:24672044 |
| Tokuda E et al. | Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer. | 2014 | Cancer Res. | pmid:24706697 |
| Hammond GR et al. | A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. | 2014 | J. Cell Biol. | pmid:24711504 |
| Charman M et al. | Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival. | 2014 | J. Biol. Chem. | pmid:24742681 |
| Dolinsky S et al. | The Legionella longbeachae Icm/Dot substrate SidC selectively binds phosphatidylinositol 4-phosphate with nanomolar affinity and promotes pathogen vacuole-endoplasmic reticulum interactions. | 2014 | Infect. Immun. | pmid:25024371 |
| Cai Y et al. | Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus. | 2014 | J. Cell Biol. | pmid:25113029 |
| Khan I et al. | Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2. | 2014 | J. Virol. | pmid:25122779 |
| Ling Y et al. | Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature. | 2014 | Mol. Biol. Cell | pmid:25165144 |
| Reghellin V et al. | NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes. | 2014 | Antimicrob. Agents Chemother. | pmid:25224012 |
| Moser von Filseck J et al. | Building lipid 'PIPelines' throughout the cell by ORP/Osh proteins. | 2014 | Biochem. Soc. Trans. | pmid:25233433 |
| Liu X and Ridgway ND | Characterization of the sterol and phosphatidylinositol 4-phosphate binding properties of Golgi-associated OSBP-related protein 9 (ORP9). | 2014 | PLoS ONE | pmid:25255026 |
| Sahyoun NE et al. | A synaptosomal protein kinase is regulated by phosphatidylinositol 4-phosphate and Mg2+. | 1989 | J. Biol. Chem. | pmid:2536015 |
| Kato H et al. | Activation of phosphatidylinositol kinase and phosphatidylinositol-4-phosphate kinase by cAMP in Saccharomyces cerevisiae. | 1989 | J. Biol. Chem. | pmid:2536734 |
| Smith CD and Chang KJ | Regulation of brain phosphatidylinositol-4-phosphate kinase by GTP analogues. A potential role for guanine nucleotide regulatory proteins. | 1989 | J. Biol. Chem. | pmid:2536738 |
| Huang HM and Gibson GE | Phosphatidylinositol metabolism during in vitro hypoxia. | 1989 | J. Neurochem. | pmid:2537378 |
| Bryckaert MC et al. | Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation. | 1989 | J. Biol. Chem. | pmid:2538439 |
| Tamiya-Koizumi K et al. | A novel phospholipase A2 associated with nuclear matrix: stimulation of the activity and modulation of the Ca2+ dependency by polyphosphoinositides. | 1989 | Biochim. Biophys. Acta | pmid:2539188 |
| Azouaoui H et al. | A high-yield co-expression system for the purification of an intact Drs2p-Cdc50p lipid flippase complex, critically dependent on and stabilized by phosphatidylinositol-4-phosphate. | 2014 | PLoS ONE | pmid:25393116 |
| King CE et al. | Determination of the steady-state turnover rates of the metabolically active pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in human erythrocytes. | 1989 | Biochem. J. | pmid:2543372 |
| Glanville NT et al. | Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin. | 1989 | Biochim. Biophys. Acta | pmid:2546591 |
| Bastyr EJ et al. | Decreased platelet phosphoinositide turnover and enhanced platelet activation in IDDM. | 1989 | Diabetes | pmid:2548908 |
| Sicart A et al. | PLCγ1 participates in protein transport and diacylglycerol production triggered by cargo arrival at the Golgi. | 2015 | Traffic | pmid:25491205 |
| Furse S et al. | Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity. | 2015 | Org. Biomol. Chem. | pmid:25515724 |
| Roulin PS et al. | Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. | 2014 | Cell Host Microbe | pmid:25525797 |
| Missiaen L et al. | Polyamines and neomycin inhibit the purified plasma-membrane Ca2+ pump by interacting with associated polyphosphoinositides. | 1989 | Biochem. J. | pmid:2552987 |
| Claro E et al. | Carbachol in the presence of guanosine 5'-O-(3-thiotriphosphate) stimulates the breakdown of exogenous phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol by rat brain membranes. | 1989 | J. Biol. Chem. | pmid:2553703 |
| Subramoniam A et al. | Influence of trichloroethylene treatment on phosphoinositides in rat brain. | 1989 | Toxicol. Lett. | pmid:2554538 |
| Steen VM et al. | Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets. | 1989 | Biochem. J. | pmid:2557003 |
| Missiaen L et al. | Role of arginine residues in the stimulation of the smooth-muscle plasma-membrane Ca2+ pump by negatively charged phospholipids. | 1989 | Biochem. J. | pmid:2557845 |
| Lenoir M et al. | Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins. | 2015 | J. Mol. Biol. | pmid:25579996 |
| Malik S et al. | G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway. | 2015 | Mol. Biol. Cell | pmid:25609085 |
| Smrcka AV | Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes. | 2015 | J. Cardiovasc. Pharmacol. | pmid:25658460 |
| Borbiro I et al. | Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. | 2015 | Sci Signal | pmid:25670203 |
| Lete MG et al. | Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate. | 2015 | Biophys. J. | pmid:25692591 |
| Lacalle RA et al. | Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity. | 2015 | FASEB J. | pmid:25713054 |
| Rajamanoharan D et al. | Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells. | 2015 | Mol. Biol. Cell | pmid:25717182 |
| Adhikari H and Cullen PJ | Role of phosphatidylinositol phosphate signaling in the regulation of the filamentous-growth mitogen-activated protein kinase pathway. | 2015 | Eukaryotic Cell | pmid:25724886 |
| Okazaki K et al. | Phosphatidylinositol 4-phosphate negatively regulates chloroplast division in Arabidopsis. | 2015 | Plant Cell | pmid:25736058 |
| Nchoutmboube J et al. | Enterovirus replication: go with the (counter)flow. | 2015 | Trends Microbiol. | pmid:25748799 |
| Stalder D and Novick PJ | Assaying the interaction of the Rab guanine nucleotide exchange protein Sec2 with the upstream Rab, a downstream effector, and a phosphoinositide. | 2015 | Methods Mol. Biol. | pmid:25800834 |
| Jeschke A et al. | Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25825728 |
| Moser von Filseck J et al. | A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes. | 2015 | Nat Commun | pmid:25849868 |
| Hsu F et al. | Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. | 2015 | J. Cell Biol. | pmid:25869669 |
| Bryant KL et al. | A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase IIIα is important for protein trafficking from the endoplasmic reticulum to the plasma membrane. | 2015 | BMC Cell Biol. | pmid:25886792 |
| Tsutsui Y et al. | Conformation-Dependent Human p52Shc Phosphorylation by Human c-Src. | 2015 | Biochemistry | pmid:25961473 |
| Kim DI et al. | Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels. | 2015 | J. Gen. Physiol. | pmid:25964431 |
| Wang H et al. | GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26038556 |
| Badheka D et al. | Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel. | 2015 | J. Gen. Physiol. | pmid:26123195 |
| Ghugtyal V et al. | Phosphatidylinositol-4-phosphate-dependent membrane traffic is critical for fungal filamentous growth. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26124136 |
| Chávez M et al. | Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output. | 2015 | Dev. Cell | pmid:26190144 |
| Chung J et al. | INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. | 2015 | Science | pmid:26206935 |
| Moser von Filseck J et al. | INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. | 2015 | Science | pmid:26206936 |
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phosphatidylinositol-4-phosphate
phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phosphatidylinositol-4-phosphate?
phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with phosphatidylinositol-4-phosphate
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phosphatidylinositol-4-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with phosphatidylinositol-4-phosphate?
There are no associated biomedical information in the current reference collection.