phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Jímenez B et al. Regulation of diacylglycerol kinase in the transition from quiescence to proliferation in Dictyostelium discoideum. 1988 Biochem. Biophys. Res. Commun. pmid:2827662
de Chaffoy de Courcelles D et al. 1-Oleoyl-2-acetyl-glycerol (OAG) stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1984 Biochem. Biophys. Res. Commun. pmid:6091634
Volpi M et al. Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils. 1983 Biochem. Biophys. Res. Commun. pmid:6303343
Zhou Y et al. A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human. 2014 Biochem. Biophys. Res. Commun. pmid:24326072
Ago T et al. The PX domain as a novel phosphoinositide- binding module. 2001 Biochem. Biophys. Res. Commun. pmid:11563857
Halenda SP and Feinstein MB Phorbol myristate acetate stimulates formation of phosphatidyl inositol 4-phosphate and phosphatidyl inositol 4,5-bisphosphate in human platelets. 1984 Biochem. Biophys. Res. Commun. pmid:6093804
Ishizuka Y et al. Polyphosphoinositide turnover in rat mast cells stimulated by antigen: rapid and preferential breakdown of phosphatidylinositol 4-phosphate (DPI). 1984 Biochem. Biophys. Res. Commun. pmid:6091652
Bordin L et al. Tyrosine-protein kinase inhibition in human erythrocytes by polyphosphoinositides (PIP and PIP2). 1992 Biochem. Biophys. Res. Commun. pmid:1382423
Hammond GR et al. Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2). 2009 Biochem. J. pmid:19508231
Flesch FM et al. Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain. 2005 Biochem. J. pmid:15755258
Waugh MG et al. Identification and characterization of differentially active pools of type IIalpha phosphatidylinositol 4-kinase activity in unstimulated A431 cells. 2003 Biochem. J. pmid:12954081
Missiaen L et al. Role of arginine residues in the stimulation of the smooth-muscle plasma-membrane Ca2+ pump by negatively charged phospholipids. 1989 Biochem. J. pmid:2557845
Steen VM et al. Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets. 1989 Biochem. J. pmid:2557003
Missiaen L et al. Polyamines and neomycin inhibit the purified plasma-membrane Ca2+ pump by interacting with associated polyphosphoinositides. 1989 Biochem. J. pmid:2552987
King CE et al. Determination of the steady-state turnover rates of the metabolically active pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in human erythrocytes. 1989 Biochem. J. pmid:2543372
Smith CD and Snyderman R Modulation of inositol phospholipid metabolism by polyamines. 1988 Biochem. J. pmid:2851975
Steen VM et al. Synergism between thrombin and adrenaline (epinephrine) in human platelets. Marked potentiation of inositol phospholipid metabolism. 1988 Biochem. J. pmid:2845924
Schäfer M et al. Ca2+ regulation of 1-(3-sn-phosphatidyl)-1D-myo-inositol 4-phosphate formation and hydrolysis on sarcoplasmic-reticular Ca2+-transport ATPase. A new principle of phospholipid turnover regulation. 1987 Biochem. J. pmid:2827632
Vickers JD and Mustard JF The phosphoinositides exist in multiple metabolic pools in rabbit platelets. 1986 Biochem. J. pmid:3026351
Zhai C et al. Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane. 2008 Biochem. J. pmid:18601652