phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Rípová D et al. Phosphoinositide signalling system in platelets of schizophrenic patients and the effect of neuroleptic therapy. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10509868
Clayton EL et al. Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. 2013 Prog. Lipid Res. pmid:23608234
Delage E et al. Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms. 2013 Prog. Lipid Res. pmid:22981911
Yanagisawa K et al. Localization of phosphatidylinositol 4,5-diphosphate on the stereocilia of cochlear hair cells. 1988 Prog. Brain Res. pmid:2847238
Stalder D et al. Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24248333
Szentpetery Z et al. Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20404150
Fairn GD et al. The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17881569
Baust T et al. Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16492770
Ungewickell A et al. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16365287
Walsh JP et al. Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. 1991 Proc. Natl. Acad. Sci. U.S.A. pmid:1656463
Watson SP and Lapetina EG 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2986126
Wassef NM et al. Suppression of phagocytic function and phospholipid metabolism in macrophages by phosphatidylinositol liposomes. 1984 Proc. Natl. Acad. Sci. U.S.A. pmid:6326135
Sohn M et al. Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:27044099
Ghugtyal V et al. Phosphatidylinositol-4-phosphate-dependent membrane traffic is critical for fungal filamentous growth. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26124136
Wang H et al. GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26038556
Jeschke A et al. Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25825728
Bianco A et al. Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity. 2012 PLoS Pathog. pmid:22412376
Banerjee S et al. Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein. 2018 PLoS Pathog. pmid:29782554
Oh HS et al. Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides. 2018 PLoS Pathog. pmid:29702686
Dorobantu CM et al. Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus. 2015 PLoS Pathog. pmid:26406250