| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| de Chaffoy de Courcelles D et al. | Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4-phosphate in intact human platelets. | 1986 | FEBS Lett. | pmid:2417883 |
| Perera IY et al. | Characterization and comparative analysis of Arabidopsis phosphatidylinositol phosphate 5-kinase 10 reveals differences in Arabidopsis and human phosphatidylinositol phosphate kinases. | 2005 | FEBS Lett. | pmid:15949803 |
| Holian A | Leukotriene B4 stimulation of phosphatidylinositol turnover in macrophages and inhibition by pertussis toxin. | 1986 | FEBS Lett. | pmid:3011502 |
| Urumow T and Wieland OH | Stimulation of phosphatidylinositol 4-phosphate phosphorylation in human placenta membranes by GTP gamma S. | 1986 | FEBS Lett. | pmid:3021533 |
| Philp NJ and Grollman EF | Thyrotropin and norepinephrine stimulate the metabolism of phosphoinositides in FRTL-5 thyroid cells. | 1986 | FEBS Lett. | pmid:3013684 |
| Hidalgo C et al. | Phosphorylation of phosphatidylinositol by transverse tubule vesicles and its possible role in excitation-contraction coupling. | 1986 | FEBS Lett. | pmid:3013681 |
| Shiozawa K et al. | The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97. | 2006 | FEBS J. | pmid:17018057 |
| Zakharian E et al. | Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) Pâ‚‚. | 2011 | FASEB J. | pmid:21810903 |
| König S et al. | Stress-inducible and constitutive phosphoinositide pools have distinctive fatty acid patterns in Arabidopsis thaliana. | 2007 | FASEB J. | pmid:17327357 |
| Lacalle RA et al. | Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity. | 2015 | FASEB J. | pmid:25713054 |
| Baughman C et al. | Nucleoside diphosphate kinase B (NDKB) scaffolds endoplasmic reticulum membranes in vitro. | 2008 | Exp. Cell Res. | pmid:18601920 |
| Szymańska E et al. | Expression of PI(4,5)P2-binding proteins lowers the PI(4,5)P2level and inhibits FcgammaRIIA-mediated cell spreading and phagocytosis. | 2008 | Eur. J. Immunol. | pmid:18050271 |
| Tomioku KN et al. | Nanoscale domain formation of phosphatidylinositol 4-phosphate in the plasma and vacuolar membranes of living yeast cells. | 2018 | Eur. J. Cell Biol. | pmid:29609807 |
| Gloor Y et al. | Interaction between Sec7p and Pik1p: the first clue for the regulation of a coincidence detection signal. | 2010 | Eur. J. Cell Biol. | pmid:20434792 |
| Vickers JD et al. | Inositol phospholipid metabolism in human platelets stimulated by ADP. | 1990 | Eur. J. Biochem. | pmid:2171937 |
| Suer S et al. | Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites. | 2001 | Eur. J. Biochem. | pmid:11277933 |
| Carricaburu V and Fournier B | Phosphoinositide fatty acids regulate phosphatidylinositol 5-kinase, phospholipase C and protein kinase C activities. | 2001 | Eur. J. Biochem. | pmid:11231275 |
| Morgan SJ et al. | Purification and characterization of bovine brain type I phosphatidylinositol kinase. | 1990 | Eur. J. Biochem. | pmid:2167854 |
| Verhoeven AJ et al. | Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets. | 1987 | Eur. J. Biochem. | pmid:3036523 |
| Sale GJ et al. | Characterization of phosphatidylinositol kinase activity associated with the insulin receptor. | 1986 | Eur. J. Biochem. | pmid:3007126 |
| Vogel S and Hoppe J | Polyamines stimulate the phosphorylation of phosphatidylinositol in membranes from A431 cells. | 1986 | Eur. J. Biochem. | pmid:3002795 |
| Lefèbvre F et al. | Secretory pathway-dependent localization of the Saccharomyces cerevisiae Rho GTPase-activating protein Rgd1p at growth sites. | 2012 | Eukaryotic Cell | pmid:22447923 |
| Adhikari H and Cullen PJ | Role of phosphatidylinositol phosphate signaling in the regulation of the filamentous-growth mitogen-activated protein kinase pathway. | 2015 | Eukaryotic Cell | pmid:25724886 |
| Jarvis WD et al. | Attenuation of anterior pituitary phosphoinositide phosphorylase activity by the D2 dopamine receptor. | 1988 | Endocrinology | pmid:2904359 |
| Gallo-Payet N et al. | Vasopressin induces breakdown of membrane phosphoinositides in adrenal glomerulosa and fasciculata cells. | 1986 | Endocrinology | pmid:3015563 |
| Brenner-Gati L and Gershengorn MC | Effects of thyrotropin-releasing hormone on phosphoinositides and cytoplasmic free calcium in thyrotropic pituitary cells. | 1986 | Endocrinology | pmid:3000732 |
| Schoebel S et al. | High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. | 2010 | EMBO Rep. | pmid:20616805 |
| Lenoir M et al. | Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains. | 2010 | EMBO Rep. | pmid:20300118 |
| Farhan H et al. | Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. | 2008 | EMBO J. | pmid:18650939 |
| Salim K et al. | Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. | 1996 | EMBO J. | pmid:8947047 |
| Mesmin B et al. | Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP. | 2017 | EMBO J. | pmid:28978670 |
| Bastyr EJ et al. | Decreased platelet phosphoinositide turnover and enhanced platelet activation in IDDM. | 1989 | Diabetes | pmid:2548908 |
| Del Bel LM et al. | The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing eye. | 2018 | Development | pmid:29752385 |
| Santiago-Tirado FH et al. | PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast. | 2011 | Dev. Cell | pmid:21238924 |
| Yavari A et al. | Role of lipid metabolism in smoothened derepression in hedgehog signaling. | 2010 | Dev. Cell | pmid:20643350 |
| Mizuno-Yamasaki E et al. | Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. | 2010 | Dev. Cell | pmid:20493815 |
| Platre MP et al. | A Combinatorial Lipid Code Shapes the Electrostatic Landscape of Plant Endomembranes. | 2018 | Dev. Cell | pmid:29754803 |
| Blumental-Perry A et al. | Phosphatidylinositol 4-phosphate formation at ER exit sites regulates ER export. | 2006 | Dev. Cell | pmid:17084359 |
| Audhya A and Emr SD | Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. | 2002 | Dev. Cell | pmid:12015967 |
| Garcia-Gonzalo FR et al. | Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. | 2015 | Dev. Cell | pmid:26305592 |
| Chávez M et al. | Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output. | 2015 | Dev. Cell | pmid:26190144 |
| De Matteis M et al. | Phosphoinositides and the golgi complex. | 2002 | Curr. Opin. Cell Biol. | pmid:12383794 |
| Simonsen A et al. | The role of phosphoinositides in membrane transport. | 2001 | Curr. Opin. Cell Biol. | pmid:11454456 |
| Wieffer M et al. | PI4K2β/AP-1-based TGN-endosomal sorting regulates Wnt signaling. | 2013 | Curr. Biol. | pmid:24206846 |
| Cooke FT et al. | The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae. | 1998 | Curr. Biol. | pmid:9811604 |
| Tan J and Brill JA | Cinderella story: PI4P goes from precursor to key signaling molecule. | Crit. Rev. Biochem. Mol. Biol. | pmid:24219382 | |
| Acosta-Andrade C et al. | Polyamine-RNA-membrane interactions: From the past to the future in biology. | 2017 | Colloids Surf B Biointerfaces | pmid:28456048 |
| Malhotra V and Campelo F | PKD regulates membrane fission to generate TGN to cell surface transport carriers. | 2011 | Cold Spring Harb Perspect Biol | pmid:21421913 |
| Riozzi A et al. | Erythrocyte phosphoinositide metabolism in essential hypertensive patients and their normotensive offspring. | 1987 | Clin. Sci. | pmid:3038455 |
| Alving BM et al. | Lupus anticoagulant activities of murine monoclonal antibodies to liposomal phosphatidylinositol phosphate. | 1987 | Clin. Exp. Immunol. | pmid:2820640 |
| Kurosawa M et al. | Formation of phosphatidylinositol-4-phosphate in human peripheral blood eosinophils. | 1993 | Clin. Exp. Allergy | pmid:10779308 |
| Waring MJ et al. | Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation. | 2014 | Chem. Commun. (Camb.) | pmid:24366037 |
| He J et al. | Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications. | 2011 | Chem. Biol. | pmid:22035800 |
| Luo R et al. | Arf GAP2 is positively regulated by coatomer and cargo. | 2009 | Cell. Signal. | pmid:19296914 |
| Santi P et al. | Changes in polyphosphoinositide levels in rat liver nuclei in response to prolactin, a known hepatic mitogen. | 1992 | Cell. Signal. | pmid:1329898 |
| Martelli AM et al. | Inositides in nuclei of Friend cells: changes of polyphosphoinositide and diacylglycerol levels accompany cell differentiation. | 1995 | Cell. Signal. | pmid:7756111 |
| Tran D et al. | Cellular distribution of polyphosphoinositides in rat hepatocytes. | 1993 | Cell. Signal. | pmid:8312134 |
| Yin P et al. | A role for retromer in hepatitis C virus replication. | 2016 | Cell. Mol. Life Sci. | pmid:26298293 |
| Domingues L et al. | The Salmonella effector SteA binds phosphatidylinositol 4-phosphate for subcellular targeting within host cells. | 2016 | Cell. Microbiol. | pmid:26676327 |
| Hilbi H | Modulation of phosphoinositide metabolism by pathogenic bacteria. | 2006 | Cell. Microbiol. | pmid:16939534 |
| van der Schaar HM et al. | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication. | 2012 | Cell Res. | pmid:22945356 |
| Anitei M et al. | Spatiotemporal Control of Lipid Conversion, Actin-Based Mechanical Forces, and Curvature Sensors during Clathrin/AP-1-Coated Vesicle Biogenesis. | 2017 | Cell Rep | pmid:28854360 |
| Zhao K and Ridgway ND | Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System. | 2017 | Cell Rep | pmid:28564600 |
| Machesky LM et al. | The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C. | 1990 | Cell Regul. | pmid:1966040 |
| Reiss S et al. | Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. | 2011 | Cell Host Microbe | pmid:21238945 |
| Roulin PS et al. | Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. | 2014 | Cell Host Microbe | pmid:25525797 |
| Wu F et al. | Hedgehog Signaling: From Basic Biology to Cancer Therapy. | 2017 | Cell Chem Biol | pmid:28286127 |
| Downes P and Michell RH | Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function. | 1982 | Cell Calcium | pmid:6297743 |
| Santavenere E et al. | Sensitivity of Daudi cells to tumor necrosis factor alpha: early changes in polyphosphoinositide metabolism. | 1996 | Cell Biol. Int. | pmid:8948126 |
| Mesmin B et al. | A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP. | 2013 | Cell | pmid:24209621 |
| Zhang L et al. | Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. | 2013 | Cell | pmid:23540699 |
| Carney DH et al. | Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. | 1985 | Cell | pmid:2992800 |
| Wang YJ et al. | Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. | 2003 | Cell | pmid:12914695 |
| Dong R et al. | Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. | 2016 | Cell | pmid:27419871 |
| Ijuin T et al. | Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer. | 2016 | Cancer Sci. | pmid:27178239 |
| Tokuda E et al. | Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer. | 2014 | Cancer Res. | pmid:24706697 |
| Waugh MG | Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer. | 2012 | Cancer Lett. | pmid:22750097 |
| Zeng XT et al. | Electrogenic and phosphatidylinositol-4-monophosphate-stimulated Cl- transport by Cl- pump in the rat brain. | 1994 | Brain Res. | pmid:8019845 |
| Vorwerk S et al. | EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana. | 2007 | BMC Plant Biol. | pmid:17612410 |
| Bryant KL et al. | A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase IIIα is important for protein trafficking from the endoplasmic reticulum to the plasma membrane. | 2015 | BMC Cell Biol. | pmid:25886792 |
| Guilherme A et al. | A novel phosphorylated lipid counteracts activation of the renal plasma membrane (Ca2+ + Mg2+)ATPase by endogenous phosphatidylinositol-4-phosphate. | 1998 | Biosci. Rep. | pmid:9743476 |
| Fung BM | New angles for NMR studies of biological molecules. | 2003 | Biophys. J. | pmid:14645039 |
| Lete MG et al. | Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate. | 2015 | Biophys. J. | pmid:25692591 |
| Lenoir M et al. | Secondary structure and 1H, 13C, 15N resonance assignments of the Golgi-specific PH domain of FAPP1. | 2011 | Biomol NMR Assign | pmid:21298564 |
| Posada V et al. | Maximal Ca2+i stimulation of cardiac Na+/Ca2+ exchange requires simultaneous alkalinization and binding of PtdIns-4,5-P2 to the exchanger. | 2007 | Biol. Chem. | pmid:17338635 |
| Müller E et al. | Dependence on intracellular Ca2+ on mass and turnover of phosphoinositides and phosphatidate in human erythrocytes. | 1997 | Biol. Chem. | pmid:9348118 |
| Minogue S | The Many Roles of Type II Phosphatidylinositol 4-Kinases in Membrane Trafficking: New Tricks for Old Dogs. | 2018 | Bioessays | pmid:29280156 |
| De Matteis MA et al. | Phosphatidylinositol-4-phosphate: the Golgi and beyond. | 2013 | Bioessays | pmid:23712958 |
| Moser von Filseck J and Drin G | Running up that hill: How to create cellular lipid gradients by lipid counter-flows. | 2016 | Biochimie | pmid:27519300 |
| Kirk CJ et al. | Hormone-mediated inositol lipid breakdown in hepatocytes and WRK1 cells: relationship to receptor function. | Biochimie | pmid:2866800 | |
| Cowen DS et al. | P2-purinergic receptors activate a guanine nucleotide-dependent phospholipase C in membranes from HL-60 cells. | 1990 | Biochim. Biophys. Acta | pmid:2166587 |
| Morris SJ et al. | Phosphoinositide metabolism in cultured glioma and neuroblastoma cells: subcellular distribution of enzymes indicate incomplete turnover at the plasma membrane. | 1990 | Biochim. Biophys. Acta | pmid:2156558 |
| Hinchliffe KA et al. | PIPkins1, their substrates and their products: new functions for old enzymes. | 1998 | Biochim. Biophys. Acta | pmid:9838059 |
| Giusto NM and Ilincheta de Boschero MG | Synthesis of polyphosphoinositides in vertebrate photoreceptor membranes. | 1986 | Biochim. Biophys. Acta | pmid:3015222 |
| van Paridon PA et al. | Polyphosphoinositides undergo charge neutralization in the physiological pH range: a 31P-NMR study. | 1986 | Biochim. Biophys. Acta | pmid:3013316 |
| Plantavid M et al. | Studies of endogenous polyphosphoinositide hydrolysis in human platelet membranes. Evidence that polyphosphoinositides remain inaccessible to phosphodiesterase in the native membrane. | 1986 | Biochim. Biophys. Acta | pmid:3002480 |
| Boggs JM et al. | Effect of phosphorylation of phosphatidylinositol on myelin basic protein-mediated binding of actin filaments to lipid bilayers in vitro. | 2012 | Biochim. Biophys. Acta | pmid:22538354 |
| Olas B et al. | Resveratrol inhibits polyphosphoinositide metabolism in activated platelets. | 2005 | Biochim. Biophys. Acta | pmid:16051184 |
| Ryningen A et al. | Elevation of cyclic AMP decreases phosphoinositide turnover and inhibits thrombin-induced secretion in human platelets. | 1998 | Biochim. Biophys. Acta | pmid:9795233 |
| Gascard P et al. | Asymmetric distribution of phosphoinositides and phosphatidic acid in the human erythrocyte membrane. | 1991 | Biochim. Biophys. Acta | pmid:1657164 |
phosphatidylinositol-4-phosphate
phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phosphatidylinositol-4-phosphate?
phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with phosphatidylinositol-4-phosphate
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phosphatidylinositol-4-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with phosphatidylinositol-4-phosphate?
There are no associated biomedical information in the current reference collection.