| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tóth JT et al. | BRET-monitoring of the dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation. | 2016 | Biochim. Biophys. Acta | pmid:26692031 |
| Stalder D and Novick PJ | The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. | 2016 | Mol. Biol. Cell | pmid:26700316 |
| Ketel K et al. | A phosphoinositide conversion mechanism for exit from endosomes. | 2016 | Nature | pmid:26760201 |
| Kentala H et al. | OSBP-Related Protein Family: Mediators of Lipid Transport and Signaling at Membrane Contact Sites. | 2016 | Int Rev Cell Mol Biol | pmid:26811291 |
| Henmi Y et al. | PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes. | 2016 | Mol. Biol. Cell | pmid:26823017 |
| Jiang K et al. | PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. | 2016 | PLoS Biol. | pmid:26863604 |
| Mesmin B and Antonny B | The counterflow transport of sterols and PI4P. | 2016 | Biochim. Biophys. Acta | pmid:26928592 |
| Yoshida A et al. | Nanoscale analysis reveals agonist-sensitive and heterogeneous pools of phosphatidylinositol 4-phosphate in the plasma membrane. | 2016 | Biochim. Biophys. Acta | pmid:26972044 |
| Klima M et al. | Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein. | 2016 | Sci Rep | pmid:27009356 |
| Sohn M et al. | Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27044099 |
| Dickson EJ et al. | Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides. | 2016 | J. Cell Biol. | pmid:27044890 |
| Lopes da Silva M et al. | Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells. | 2016 | J. Cell. Sci. | pmid:27068535 |
| Berryman S et al. | Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases. | 2016 | J. Gen. Virol. | pmid:27093462 |
| Tabaei SR et al. | Multistep Compositional Remodeling of Supported Lipid Membranes by Interfacially Active Phosphatidylinositol Kinases. | 2016 | Anal. Chem. | pmid:27118725 |
| Tenorio MJ et al. | Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. | 2016 | PLoS ONE | pmid:27123979 |
| Ijuin T et al. | Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer. | 2016 | Cancer Sci. | pmid:27178239 |
| Simon ML et al. | A PtdIns(4)P-driven electrostatic field controls cell membrane identity and signalling in plants. | 2016 | Nat Plants | pmid:27322096 |
| Marquer C et al. | Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism. | 2016 | Nat Commun | pmid:27336679 |
| Rizzo R et al. | GOLPH3 and oncogenesis: What is the molecular link? | 2017 | Tissue Cell | pmid:27378035 |
| Dong R et al. | Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. | 2016 | Cell | pmid:27419871 |
| Moser von Filseck J and Drin G | Running up that hill: How to create cellular lipid gradients by lipid counter-flows. | 2016 | Biochimie | pmid:27519300 |
| Jin MW et al. | [Effect of phosphoinositide 4-phosphate on invasion and migration of human glioma U87 cells]. | 2016 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:27530799 |
| Baumlova A et al. | The structural basis for calcium inhibition of lipid kinase PI4K IIalpha and comparison with the apo state. | 2016 | Physiol Res | pmid:27539108 |
| Xing M et al. | GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. | 2016 | Mol. Biol. Cell | pmid:27708138 |
| Alli-Balogun GO et al. | Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype. | 2016 | Mol. Biol. Cell | pmid:27798239 |
| Altan-Bonnet N | Lipid Tales of Viral Replication and Transmission. | 2017 | Trends Cell Biol. | pmid:27838086 |
| Zhang JQ et al. | Persistency of Enlarged Autolysosomes Underscores Nanoparticle-Induced Autophagy in Hepatocytes. | 2017 | Small | pmid:27925395 |
| Dong N et al. | Modulation of membrane phosphoinositide dynamics by the phosphatidylinositide 4-kinase activity of the Legionella LepB effector. | 2016 | Nat Microbiol | pmid:27941800 |
| Levin R et al. | Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis. | 2017 | Mol. Biol. Cell | pmid:28035045 |
| Bone LN et al. | The acyltransferase LYCAT controls specific phosphoinositides and related membrane traffic. | 2017 | Mol. Biol. Cell | pmid:28035047 |
| Li L et al. | A phosphoinositide-specific phospholipase C pathway elicits stress-induced Ca signals and confers salt tolerance to rice. | 2017 | New Phytol. | pmid:28157263 |
| Alving BM et al. | Lupus anticoagulant activities of murine monoclonal antibodies to liposomal phosphatidylinositol phosphate. | 1987 | Clin. Exp. Immunol. | pmid:2820640 |
| Hegewald H et al. | Influence of Ca2+ and Mg2+ on the turnover of the phosphomonoester group of phosphatidylinositol 4-phosphate in human erythrocyte membranes. | 1987 | Biochem. J. | pmid:2821996 |
| Lundberg GA et al. | Activation of phosphatidylinositol-4-phosphate kinase in rat liver plasma membranes by polyamines. | 1987 | Biochim. Biophys. Acta | pmid:2822135 |
| Natarajan V and Schmid HH | Inositol phospholipid hydrolysis by rat sciatic nerve phospholipase C. | 1987 | J. Neurochem. | pmid:2824695 |
| Schäfer M et al. | Ca2+ regulation of 1-(3-sn-phosphatidyl)-1D-myo-inositol 4-phosphate formation and hydrolysis on sarcoplasmic-reticular Ca2+-transport ATPase. A new principle of phospholipid turnover regulation. | 1987 | Biochem. J. | pmid:2827632 |
| JÃmenez B et al. | Regulation of diacylglycerol kinase in the transition from quiescence to proliferation in Dictyostelium discoideum. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2827662 |
| Wu F et al. | Hedgehog Signaling: From Basic Biology to Cancer Therapy. | 2017 | Cell Chem Biol | pmid:28286127 |
| De Craene JO et al. | Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways. | 2017 | Int J Mol Sci | pmid:28294977 |
| Sayyed SG et al. | The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins. | 2017 | Kidney Int. | pmid:28302370 |
| Azouaoui H et al. | High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions. | 2017 | J. Biol. Chem. | pmid:28302728 |
| Giraud F et al. | Stimulation of polyphosphoinositide turnover upon activation of protein kinases in human erythrocytes. | 1988 | Biochim. Biophys. Acta | pmid:2830906 |
| Pike MC and Arndt C | Characterization of phosphatidylinositol and phosphatidylinositol-4-phosphate kinases in human neutrophils. | 1988 | J. Immunol. | pmid:2831274 |
| Manik MK et al. | Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction. | 2017 | Structure | pmid:28319008 |
| Einspahr KJ et al. | Rapid changes in polyphosphoinositide metabolism associated with the response of Dunaliella salina to hypoosmotic shock. | 1988 | J. Biol. Chem. | pmid:2833516 |
| Whitman M et al. | Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. | 1988 | Nature | pmid:2833705 |
| Khadka B and Gupta RS | Identification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role. | 2017 | Proteins | pmid:28407364 |
| Van Paridon PA et al. | The effect of polyphosphoinositides and phosphatidic acid on the phosphatidylinositol transfer protein from bovine brain: a kinetic study. | 1988 | Biochim. Biophys. Acta | pmid:2840959 |
| Berti A et al. | Effect of exogenously added acylphosphatases on inositol lipid metabolism in human platelets. | 1988 | FEBS Lett. | pmid:2841154 |
| Saha AK et al. | Legionella micdadei phosphatase catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate in human neutrophils. | 1988 | Arch. Biochem. Biophys. | pmid:2843104 |
| Chauhan VP and Brockerhoff H | Phosphatidylinositol-4,5-bisphosphate may antecede diacylglycerol as activator of protein kinase C. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843176 |
| Acosta-Andrade C et al. | Polyamine-RNA-membrane interactions: From the past to the future in biology. | 2017 | Colloids Surf B Biointerfaces | pmid:28456048 |
| Steen VM et al. | Synergism between thrombin and adrenaline (epinephrine) in human platelets. Marked potentiation of inositol phospholipid metabolism. | 1988 | Biochem. J. | pmid:2845924 |
| Fukui T et al. | Purification of a phospholipase C from rat liver cytosol that acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate. | 1988 | J. Biol. Chem. | pmid:2846577 |
| Charman M et al. | Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1. | 2017 | Traffic | pmid:28471037 |
| Yanagisawa K et al. | Localization of phosphatidylinositol 4,5-diphosphate on the stereocilia of cochlear hair cells. | 1988 | Prog. Brain Res. | pmid:2847238 |
| Smith CD and Snyderman R | Modulation of inositol phospholipid metabolism by polyamines. | 1988 | Biochem. J. | pmid:2851975 |
| Hanes CM et al. | Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate. | 2017 | J. Immunol. | pmid:28539432 |
| Zhao K and Ridgway ND | Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System. | 2017 | Cell Rep | pmid:28564600 |
| Yoshida A et al. | Segregation of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate into distinct microdomains on the endosome membrane. | 2017 | Biochim Biophys Acta Biomembr | pmid:28648675 |
| Prashek J et al. | Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain. | 2017 | J. Biol. Chem. | pmid:28652409 |
| Kirk CJ et al. | Hormone-mediated inositol lipid breakdown in hepatocytes and WRK1 cells: relationship to receptor function. | Biochimie | pmid:2866800 | |
| Hirama T et al. | Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane. | 2017 | J. Biol. Chem. | pmid:28698382 |
| Banerjee S and Kane PM | Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast. | 2017 | Mol. Biol. Cell | pmid:28720663 |
| Du X et al. | The role of oxysterol-binding protein and its related proteins in cancer. | 2018 | Semin. Cell Dev. Biol. | pmid:28733164 |
| Anitei M et al. | Spatiotemporal Control of Lipid Conversion, Actin-Based Mechanical Forces, and Curvature Sensors during Clathrin/AP-1-Coated Vesicle Biogenesis. | 2017 | Cell Rep | pmid:28854360 |
| Gulyás G et al. | Plasma membrane phosphatidylinositol 4-phosphate and 4,5-bisphosphate determine the distribution and function of K-Ras4B but not H-Ras proteins. | 2017 | J. Biol. Chem. | pmid:28939768 |
| Allgood SC et al. | Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner. | 2017 | Front Cell Infect Microbiol | pmid:28944216 |
| Ghai R et al. | ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P ) and regulate its level at the plasma membrane. | 2017 | Nat Commun | pmid:28970484 |
| Mesmin B et al. | Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP. | 2017 | EMBO J. | pmid:28978670 |
| Jarvis WD et al. | Attenuation of anterior pituitary phosphoinositide phosphorylase activity by the D2 dopamine receptor. | 1988 | Endocrinology | pmid:2904359 |
| He K et al. | Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. | 2017 | Nature | pmid:29236694 |
| Sampaio LS et al. | Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies? | 2017 | Lipids Health Dis | pmid:29246161 |
| Minogue S | The Many Roles of Type II Phosphatidylinositol 4-Kinases in Membrane Trafficking: New Tricks for Old Dogs. | 2018 | Bioessays | pmid:29280156 |
| Madukwe JC et al. | G protein βγ subunits directly interact with and activate phospholipase Cϵ. | 2018 | J. Biol. Chem. | pmid:29535186 |
| Tomioku KN et al. | Nanoscale domain formation of phosphatidylinositol 4-phosphate in the plasma and vacuolar membranes of living yeast cells. | 2018 | Eur. J. Cell Biol. | pmid:29609807 |
| Iwama R et al. | Osh6p, a homologue of the oxysterol-binding protein, is involved in production of functional cytochrome P450 belonging to CYP52 family in n-alkane-assimilating yeast Yarrowia lipolytica. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29621549 |
| Melia CE et al. | The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles. | 2018 | MBio | pmid:29666283 |
| Oh HS et al. | Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides. | 2018 | PLoS Pathog. | pmid:29702686 |
| Lundquist MR et al. | Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. | 2018 | Mol. Cell | pmid:29727621 |
| Del Bel LM et al. | The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing eye. | 2018 | Development | pmid:29752385 |
| Platre MP et al. | A Combinatorial Lipid Code Shapes the Electrostatic Landscape of Plant Endomembranes. | 2018 | Dev. Cell | pmid:29754803 |
| Banerjee S et al. | Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein. | 2018 | PLoS Pathog. | pmid:29782554 |
| Van Rooijen LA et al. | Tetraenoic species are conserved in muscarinically enhanced inositide turnover. | 1985 | J. Neurochem. | pmid:2981288 |
| Quist E | Ca2+-stimulated phospholipid phosphoesterase activities in rabbit erythrocyte membranes. | 1985 | Arch. Biochem. Biophys. | pmid:2981504 |
| Wilson DB et al. | Phosphoinositide interconversion in thrombin-stimulated human platelets. | 1985 | J. Biol. Chem. | pmid:2981829 |
| Cockcroft S et al. | Breakdown and synthesis of polyphosphoinositides in fMetLeuPhe-stimulated neutrophils. | 1985 | FEBS Lett. | pmid:2982660 |
| Taylor D et al. | Insulin and epidermal growth factor do not affect phosphoinositide metabolism in rat liver plasma membranes and hepatocytes. | 1985 | J. Biol. Chem. | pmid:2982801 |
| Holian A and Stickle DF | Calcium regulation of phosphatidyl inositol turnover in macrophage activation by formyl peptides. | 1985 | J. Cell. Physiol. | pmid:2982888 |
| van Dongen CJ et al. | Microdetermination of phosphoinositides in a single extract. | 1985 | Anal. Biochem. | pmid:2984954 |
| Watson SP and Lapetina EG | 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2986126 |
| Volpi M et al. | Phorbol 12-myristate, 13-acetate potentiates the action of the calcium ionophore in stimulating arachidonic acid release and production of phosphatidic acid in rabbit neutrophils. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2986620 |
| Smith CD et al. | Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. | 1985 | J. Biol. Chem. | pmid:2987206 |
| Mukherjee P et al. | Lipid and membrane recognition by the oxysterol binding protein and its phosphomimetic mutant using dual polarization interferometry. | 2018 | Biochim Biophys Acta Biomembr | pmid:29879417 |
| Knowles AF and Lawrence CM | Enzymatic synthesis and hydrolysis of [32P]phosphatidylinositol phosphate. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2988548 |
| Le Peuch Cj et al. | Parthenogenetic activation decreases the polyphosphoinositide content of frog eggs. | 1985 | FEBS Lett. | pmid:2991011 |
| Carney DH et al. | Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. | 1985 | Cell | pmid:2992800 |
| Tallant EA and Wallace RW | Calmodulin antagonists elevate the levels of 32P-labeled polyphosphoinositides in human platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994657 |
| Moriwaki Y et al. | SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes. | 2018 | PLoS ONE | pmid:29953492 |
| Van Rooijen LA and Agranoff BW | Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics. | 1985 | Neurochem. Res. | pmid:2997640 |
phosphatidylinositol-4-phosphate
phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with phosphatidylinositol-4-phosphate?
phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with phosphatidylinositol-4-phosphate
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with phosphatidylinositol-4-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with phosphatidylinositol-4-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with phosphatidylinositol-4-phosphate?
There are no associated biomedical information in the current reference collection.