phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Nakatsu F et al. PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. 2012 J. Cell Biol. pmid:23229899
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van der Schaar HM et al. Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication. 2012 Cell Res. pmid:22945356
Shulga YV et al. Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator. 2012 J. Biol. Chem. pmid:22942276
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Boggs JM et al. Effect of phosphorylation of phosphatidylinositol on myelin basic protein-mediated binding of actin filaments to lipid bilayers in vitro. 2012 Biochim. Biophys. Acta pmid:22538354
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Mousley CJ et al. Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality. 2012 Subcell. Biochem. pmid:22374094
Zhang L et al. ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. 2012 PLoS ONE pmid:22359663
Jacquot A et al. Phosphatidylserine stimulation of Drs2p·Cdc50p lipid translocase dephosphorylation is controlled by phosphatidylinositol-4-phosphate. 2012 J. Biol. Chem. pmid:22351780
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Fairn GD and Grinstein S Cell biology. Precursor or charge supplier? 2012 Science pmid:22879491
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Minogue S and Waugh MG The phosphatidylinositol 4-kinases: don't call it a comeback. 2012 Subcell. Biochem. pmid:22403072
D'Angelo G et al. Phosphoinositides in Golgi complex function. 2012 Subcell. Biochem. pmid:22374093
Sun Y and Drubin DG Pik1-ing clathrin adaptors. 2012 Nat. Cell Biol. pmid:22344031
Gonorazky G et al. Phosphatidylinositol 4-phosphate is associated to extracellular lipoproteic fractions and is detected in tomato apoplastic fluids. 2012 Plant Biol (Stuttg) pmid:21972816
Levine TP Lipid traffic: Osh4p makes an unexpected exchange. 2011 J. Cell Biol. pmid:22162132
Tai AW and Salloum S The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement. 2011 PLoS ONE pmid:22022594
Martín-Acebes MA et al. West Nile virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids. 2011 PLoS ONE pmid:21949814
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Berger KL et al. Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication. 2011 J. Virol. pmid:21697487
He J et al. Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. 2011 J. Biol. Chem. pmid:21454700
Malhotra V and Campelo F PKD regulates membrane fission to generate TGN to cell surface transport carriers. 2011 Cold Spring Harb Perspect Biol pmid:21421913
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Dumaresq-Doiron K et al. The phosphatidylinositol 4-kinase PI4KIIIalpha is required for the recruitment of GBF1 to Golgi membranes. 2010 J. Cell. Sci. pmid:20530568
Mizuno-Yamasaki E et al. Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. 2010 Dev. Cell pmid:20493815
Szentpetery Z et al. Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20404150
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