phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
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Qin Y et al. Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl. 2009 J. Biol. Chem. pmid:19561074
Korzeniowski MK et al. Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. 2009 J. Biol. Chem. pmid:19483082
Brice SE et al. Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae. 2009 J. Biol. Chem. pmid:19139096
Brombacher E et al. Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila. 2009 J. Biol. Chem. pmid:19095644
Seifert JP et al. RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism. 2004 J. Biol. Chem. pmid:15322077
Roy A and Levine TP Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. 2004 J. Biol. Chem. pmid:15271978
Wild AC et al. The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate. 2004 J. Biol. Chem. pmid:14766750
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Smith CD and Chang KJ Regulation of brain phosphatidylinositol-4-phosphate kinase by GTP analogues. A potential role for guanine nucleotide regulatory proteins. 1989 J. Biol. Chem. pmid:2536738
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Sahyoun NE et al. A synaptosomal protein kinase is regulated by phosphatidylinositol 4-phosphate and Mg2+. 1989 J. Biol. Chem. pmid:2536015
Fukui T et al. Purification of a phospholipase C from rat liver cytosol that acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate. 1988 J. Biol. Chem. pmid:2846577
Einspahr KJ et al. Rapid changes in polyphosphoinositide metabolism associated with the response of Dunaliella salina to hypoosmotic shock. 1988 J. Biol. Chem. pmid:2833516
Smith CD et al. Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. 1985 J. Biol. Chem. pmid:2987206
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Wilson DB et al. Phosphoinositide interconversion in thrombin-stimulated human platelets. 1985 J. Biol. Chem. pmid:2981829