phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.

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Introduction

To understand associated biological information of phosphatidylinositol-4-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phosphatidylinositol-4-phosphate?

phosphatidylinositol-4-phosphate is suspected in Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection, Rhinovirus infection, Enterovirus Infections and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phosphatidylinositol-4-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with phosphatidylinositol-4-phosphate?

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What functions are associated with phosphatidylinositol-4-phosphate?


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What lipids are associated with phosphatidylinositol-4-phosphate?

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What genes are associated with phosphatidylinositol-4-phosphate?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with phosphatidylinositol-4-phosphate?

There are no associated biomedical information in the current reference collection.

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All references with phosphatidylinositol-4-phosphate

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Authors Title Published Journal PubMed Link
Vickers JD Extraction of polyphosphoinositides from platelets: comparison of a two-step procedure with a common single-step extraction procedure. 1995 Anal. Biochem. pmid:7710110
Roldan ER et al. Exocytosis in spermatozoa in response to progesterone and zona pellucida. 1994 Science pmid:7985030
Tong W and Sun GY Phosphorylation of lipids in rat primary glial cells and immortalized astrocytes (DITNC). 1994 Lipids pmid:8090058
James SR et al. Interfacial hydrolysis of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate by turkey erythrocyte phospholipase C. 1994 Biochem. J. pmid:8135761
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Brearley CA and Hanke DE Pathway of synthesis of 3,4- and 4,5-phosphorylated phosphatidylinositols in the duckweed Spirodela polyrhiza L. 1993 Biochem. J. pmid:8382475
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Kurosawa M et al. Formation of phosphatidylinositol-4-phosphate in human peripheral blood eosinophils. 1993 Clin. Exp. Allergy pmid:10779308
Tran D et al. Cellular distribution of polyphosphoinositides in rat hepatocytes. 1993 Cell. Signal. pmid:8312134
Santi P et al. Changes in polyphosphoinositide levels in rat liver nuclei in response to prolactin, a known hepatic mitogen. 1992 Cell. Signal. pmid:1329898
Divecha N et al. Purification and characterization of phosphatidylinositol 4-phosphate 5-kinases. 1992 Biochem. J. pmid:1334412
Janmey PA et al. Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin. 1992 J. Biol. Chem. pmid:1318302
Roldan ER and Harrison RA The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols. 1992 Biochem. J. pmid:1311174
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Fukami K et al. Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function. 1992 Nature pmid:1326084
Katakami Y et al. Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex. 1992 Biochim. Biophys. Acta pmid:1322701
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Khalaf LJ and Laychock SG Phosphatidylinositol availability and polyphosphoinositide synthesis in pancreatic islet cell membranes. 1992 Biochem. Pharmacol. pmid:1314058
Walsh JP et al. Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. 1991 Proc. Natl. Acad. Sci. U.S.A. pmid:1656463
Martelli AM et al. Mitogen-stimulated events in nuclei of Swiss 3T3 cells. Evidence for a direct link between changes of inositol lipids, protein kinase C requirement and the onset of DNA synthesis. 1991 FEBS Lett. pmid:1646120
Lee CH and Hajra AK Molecular species of diacylglycerols and phosphoglycerides and the postmortem changes in the molecular species of diacylglycerols in rat brains. 1991 J. Neurochem. pmid:1846396
Chauhan A et al. Interaction of protein kinase C with phosphoinositides. 1991 Arch. Biochem. Biophys. pmid:1654811
de Wolf FA et al. Characterization of the interaction of doxorubicin with (poly)phosphoinositides in model systems. Evidence for specific interaction with phosphatidylinositol-monophosphate and -diphosphate. 1991 FEBS Lett. pmid:1652476
Kellerer M et al. Stimulation of phospholipase C activity by insulin is mediated by both isotypes of the human insulin receptor. 1991 Biochem. Biophys. Res. Commun. pmid:1661583
Gascard P et al. Asymmetric distribution of phosphoinositides and phosphatidic acid in the human erythrocyte membrane. 1991 Biochim. Biophys. Acta pmid:1657164
Conway BR et al. Comparative effects of epidermal growth factor and carbachol on phosphoinositide synthesis and breakdown in pancreatic acinar cells. 1991 Biochem. Biophys. Res. Commun. pmid:1650199
Tusupov OK et al. Proteolytic fragment of protein kinase C (kinase M) phosphorylates in vitro phosphatidylinositol-4-phosphate. 1991 Biochem. Biophys. Res. Commun. pmid:1645534
von Euler G and von Euler A Dopamine D2 receptors attenuate phosphatidylinositol 4,5-bisphosphate in synaptosomal membranes from rat neostriatum. 1991 J. Neurochem. pmid:1846171
Ferchmin PA Are polyamines modulators of the CNS? 1991 Ann. N. Y. Acad. Sci. pmid:1679312
Cowen DS et al. P2-purinergic receptors activate a guanine nucleotide-dependent phospholipase C in membranes from HL-60 cells. 1990 Biochim. Biophys. Acta pmid:2166587
Morris SJ et al. Phosphoinositide metabolism in cultured glioma and neuroblastoma cells: subcellular distribution of enzymes indicate incomplete turnover at the plasma membrane. 1990 Biochim. Biophys. Acta pmid:2156558
Kellerer M et al. TPA inhibits insulin stimulated PIP hydrolysis in fat cell membranes: evidence for modulation of insulin dependent phospholipase C by proteinkinase C. 1990 Biochem. Biophys. Res. Commun. pmid:2173567
Vickers JD et al. Inositol phospholipid metabolism in human platelets stimulated by ADP. 1990 Eur. J. Biochem. pmid:2171937
Eng SP and Lo CS Mastoparan increases membrane bound phosphatidylinositol kinase and phosphatidylinositol 4-monophosphate kinase activities in Madin-Darby canine kidney cells. 1990 Life Sci. pmid:2154653
Machesky LM et al. The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C. 1990 Cell Regul. pmid:1966040
Bazenet CE et al. The human erythrocyte contains two forms of phosphatidylinositol-4-phosphate 5-kinase which are differentially active toward membranes. 1990 J. Biol. Chem. pmid:2170402
Morgan SJ et al. Purification and characterization of bovine brain type I phosphatidylinositol kinase. 1990 Eur. J. Biochem. pmid:2167854
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Glanville NT et al. Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin. 1989 Biochim. Biophys. Acta pmid:2546591
Tamiya-Koizumi K et al. A novel phospholipase A2 associated with nuclear matrix: stimulation of the activity and modulation of the Ca2+ dependency by polyphosphoinositides. 1989 Biochim. Biophys. Acta pmid:2539188
Huang HM and Gibson GE Phosphatidylinositol metabolism during in vitro hypoxia. 1989 J. Neurochem. pmid:2537378
Missiaen L et al. Role of arginine residues in the stimulation of the smooth-muscle plasma-membrane Ca2+ pump by negatively charged phospholipids. 1989 Biochem. J. pmid:2557845
Claro E et al. Carbachol in the presence of guanosine 5'-O-(3-thiotriphosphate) stimulates the breakdown of exogenous phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol by rat brain membranes. 1989 J. Biol. Chem. pmid:2553703
Steen VM et al. Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets. 1989 Biochem. J. pmid:2557003
Missiaen L et al. Polyamines and neomycin inhibit the purified plasma-membrane Ca2+ pump by interacting with associated polyphosphoinositides. 1989 Biochem. J. pmid:2552987