Citraconic acid

Citraconic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 294 references associated with Citraconic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Citraconic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Citraconic acid

MeSH term MeSH ID Detail
Psoriasis D011565 47 associated lipids
Total 1

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Citraconic acid

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Authors Title Published Journal PubMed Link
Helwa I et al. Anti-Psoriatic Drug Monomethylfumarate Increases Nuclear Factor Erythroid 2-Related Factor 2 Levels and Induces Aquaporin-3 mRNA and Protein Expression. 2017 J. Pharmacol. Exp. Ther. pmid:28515158
Hahn JN et al. Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis. 2016 J. Immunol. pmid:27733550
Yao Y et al. Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice. 2016 Transl Stroke Res pmid:27614618
Ahuja M et al. Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. 2016 J. Neurosci. pmid:27277809
Vego H et al. Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CD107a. 2016 Cell. Mol. Immunol. pmid:25435072
Al-Jaderi Z and Maghazachi AA Vitamin D₃ and monomethyl fumarate enhance natural killer cell lysis of dendritic cells and ameliorate the clinical score in mice suffering from experimental autoimmune encephalomyelitis. 2015 Toxins (Basel) pmid:26580651
Haarmann A et al. Fumaric Acid Esters Do Not Reduce Inflammatory NF-κB/p65 Nuclear Translocation, ICAM-1 Expression and T-Cell Adhesiveness of Human Brain Microvascular Endothelial Cells. 2015 Int J Mol Sci pmid:26287168
Gillard GO et al. DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner. 2015 J. Neuroimmunol. pmid:26004161
Xie X et al. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. 2015 Br. J. Pharmacol. pmid:25953698
Helwa I et al. The antipsoriatic agent monomethylfumarate has antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes. 2015 J. Pharmacol. Exp. Ther. pmid:25332455
Kronen M et al. Mesaconase Activity of Class I Fumarase Contributes to Mesaconate Utilization by Burkholderia xenovorans. 2015 Appl. Environ. Microbiol. pmid:26070669
Cao J et al. Polymeric micelles with citraconic amide as pH-sensitive bond in backbone for anticancer drug delivery. 2014 Int J Pharm pmid:24836667
Promsote W et al. Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina. 2014 Invest. Ophthalmol. Vis. Sci. pmid:24825111
Karaman R et al. Prodrugs of fumarate esters for the treatment of psoriasis and multiple sclerosis--a computational approach. 2013 J Mol Model pmid:22940872
Ananth S et al. Induction of the cystine/glutamate exchanger SLC7A11 in retinal pigment epithelial cells by the antipsoriatic drug monomethylfumarate. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23404113
Bénardais K et al. Effects of fumaric acid esters on blood-brain barrier tight junction proteins. 2013 Neurosci. Lett. pmid:24076006
Förster A et al. Dimethylfumarate induces apoptosis in human mast cells. 2013 Exp. Dermatol. pmid:24112621
Bozard BR et al. Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate. 2012 Glia pmid:22072423
Yi Q et al. Clinical characteristics and gene mutation analysis of methylmalonic aciduria. 2011 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:21671183
Zoghi S et al. Cytokine secretion pattern in treatment of lymphocytes of multiple sclerosis patients with fumaric acid esters. 2011 Immunol. Invest. pmid:21510778
Khomyakova M et al. A methylaspartate cycle in haloarchaea. 2011 Science pmid:21252347
Leschziner G et al. Lymphomatosis cerebri presenting as a rapidly progressive dementia with a high methylmalonic acid. 2011 J. Neurol. pmid:21365456
Tangney CC et al. Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination. 2011 Neurology pmid:21947532
Wallbrecht K et al. Downregulation of endothelial adhesion molecules by dimethylfumarate, but not monomethylfumarate, and impairment of dynamic lymphocyte-endothelial cell interactions. 2011 Exp. Dermatol. pmid:21995308
Moharregh-Khiabani D et al. Effects of fumaric acids on cuprizone induced central nervous system de- and remyelination in the mouse. 2010 PLoS ONE pmid:20668697
Guccione E et al. Reduction of fumarate, mesaconate and crotonate by Mfr, a novel oxygen-regulated periplasmic reductase in Campylobacter jejuni. 2010 Environ. Microbiol. pmid:19919540
Al-Deyab SS et al. Synthesis, characterization and reactivity ratio study of poly(di(tri-n-butyltin) citraconate-co-N-vinylimidazole). 2010 Molecules pmid:20657390
Rostami-Yazdi M et al. Pharmacokinetics of anti-psoriatic fumaric acid esters in psoriasis patients. 2010 Arch. Dermatol. Res. pmid:20574745
Himeda Y et al. Catalytic (transfer) deuterogenation in D2O as deuterium source with H2 and HCO2H as electron sources. 2009 Dalton Trans pmid:19655059
Celik T et al. Urinary methylmalonic acid in patients with acute myocardial infarction. 2009 Med Princ Pract pmid:19349725
Alelú-Paz R et al. A new antigen retrieval technique for human brain tissue. 2008 PLoS ONE pmid:18852880
Tang H et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. 2008 Biochem. Biophys. Res. Commun. pmid:18722346
Litjens NH et al. Effects of monomethylfumarate on dendritic cell differentiation. 2006 Br. J. Dermatol. pmid:16433787
Wardrope C et al. Fumarate reductase: structural and mechanistic insights from the catalytic reduction of 2-methylfumarate. 2006 FEBS Lett. pmid:16497301
Pela I et al. Hyperkalemia after acute metabolic decompensation in two children with vitamin B12-unresponsive methylmalonic acidemia and normal renal function. 2006 Clin. Nephrol. pmid:16878438
Namimatsu S et al. Reversing the effects of formalin fixation with citraconic anhydride and heat: a universal antigen retrieval method. 2005 J. Histochem. Cytochem. pmid:15637333
Litjens NH et al. In vitro pharmacokinetics of anti-psoriatic fumaric acid esters. 2004 BMC Pharmacol. pmid:15479475
Litjens NH et al. Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in down-regulated Th1 lymphocyte responses. 2004 Eur. J. Immunol. pmid:14768062
Wimalasena DS et al. Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine beta-mono-oxygenase reaction. 2002 Biochem. J. pmid:12038965
Rao KS and Mishra SH Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. 1998 J Ethnopharmacol pmid:9613834
Befani O et al. Serum amine oxidase can specifically recognize and oxidize aminohexyl (AH) chains on AH-Sepharose support: single-step affinity immobilization. 1998 Biotechnol. Appl. Biochem. pmid:9756636
Asadullah K et al. Influence of monomethylfumarate on monocytic cytokine formation--explanation for adverse and therapeutic effects in psoriasis? 1997 Arch. Dermatol. Res. pmid:9444385
Li W and Wang JC Footprinting of yeast DNA topoisomerase II lysyl side chains involved in substrate binding and interdomainal interactions. 1997 J. Biol. Chem. pmid:9388273
Nibbering PH et al. Intracellular signalling by binding sites for the antipsoriatic agent monomethylfumarate on human granulocytes. 1997 Br. J. Dermatol. pmid:9274627
de Jong R et al. Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate. 1996 Eur. J. Immunol. pmid:8814248
Thio HB et al. Fumaric acid derivatives evoke a transient increase in intracellular free calcium concentration and inhibit the proliferation of human keratinocytes. 1994 Br. J. Dermatol. pmid:7857839
van der Werf MJ et al. Thermodynamics of the maleate and citraconate hydration reactions catalysed by malease from Pseudomonas pseudoalcaligenes. 1993 Eur. J. Biochem. pmid:8223624
Nibbering PH et al. Effects of monomethylfumarate on human granulocytes. 1993 J. Invest. Dermatol. pmid:8392528
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