| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Diseases | D001927 | 27 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Leukocytosis | D007964 | 9 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Vomiting | D014839 | 21 associated lipids |
| Central Nervous System Diseases | D002493 | 10 associated lipids |
Ethylmalonic acid
Ethylmalonic acid is a lipid of Fatty Acyls (FA) class. Ethylmalonic acid is associated with abnormalities such as Petechiae and Metabolic Diseases. The involved functions are known as Oxidation, Catabolic Process, Excretory function and Acidemia. Ethylmalonic acid often locates in Mitochondria. The associated genes with Ethylmalonic acid are N-caproylglycine and ETHE1 gene. The related lipids are Fatty Acids and sebacic acid.
Cross Reference
Introduction
To understand associated biological information of Ethylmalonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ethylmalonic acid?
Ethylmalonic acid is suspected in Petechiae, Metabolic Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ethylmalonic acid
PubChem Associated disorders and diseases
What pathways are associated with Ethylmalonic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ethylmalonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ethylmalonic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ethylmalonic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ethylmalonic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ethylmalonic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ethylmalonic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Ethylmalonic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Dusheiko G et al. | Recurrent hypoglycemia associated with glutaric aciduria type II in an adult. | 1979 | N. Engl. J. Med. | pmid:514320 |
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| Montgomery JA et al. | Metabolism of ethylmalonate to mesaconate in the rat. Evidence for trans-dehydrogenation of methylsuccinate. | 1983 | Biochem. J. | pmid:6225430 |
| Amendt BA and Rhead WJ | The multiple acyl-coenzyme A dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria. Mitochondrial fatty acid oxidation, acyl-coenzyme A dehydrogenase, and electron transfer flavoprotein activities in fibroblasts. | 1986 | J. Clin. Invest. | pmid:3722376 |
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| Eastman MA et al. | Conformation of the 18-23 loop region of bovine prothrombin in the absence and presence of a model Ca2+ ion. An energy minimization study. | 1986 | Int. J. Pept. Protein Res. | pmid:3733321 |
| Srb V et al. | Cytogenetic monitoring of a 24-hour effect of ethylmalonate platinum complex on human peripheral blood lymphocytes. | 1986 | Neoplasma | pmid:3785467 |
| Gregersen N et al. | Riboflavin responsive multiple acyl-CoA dehydrogenation deficiency. Assessment of 3 years of riboflavin treatment. | 1986 | Acta Paediatr Scand | pmid:3751563 |
| Amendt BA et al. | Short-chain acyl-coenzyme A dehydrogenase deficiency. Clinical and biochemical studies in two patients. | 1987 | J. Clin. Invest. | pmid:3571488 |
| Harpey JP et al. | Sudden infant death syndrome and multiple acyl-coenzyme A dehydrogenase deficiency, ethylmalonic-adipic aciduria, or systemic carnitine deficiency. | 1987 | J. Pediatr. | pmid:3585604 |
| O'Harte FP et al. | Methylmalonic acid in the diagnosis of cobalt deficiency in barley-fed lambs. | 1989 | Br. J. Nutr. | pmid:2605162 |
| Schiffer SP et al. | Organic aciduria and butyryl CoA dehydrogenase deficiency in BALB/cByJ mice. | 1989 | Biochem. Genet. | pmid:2712823 |
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| Hoffmann GF et al. | Progressive fatal pancytopenia, psychomotor retardation and muscle carnitine deficiency in a child with ethylmalonic aciduria and ethylmalonic acidaemia. | 1990 | J. Inherit. Metab. Dis. | pmid:2172644 |
| Rinaldo P et al. | Ethylmalonic/adipic aciduria: effects of oral medium-chain triglycerides, carnitine, and glycine on urinary excretion of organic acids, acylcarnitines, and acylglycines. | 1991 | Pediatr. Res. | pmid:1945558 |
| Burlina A et al. | New clinical phenotype of branched-chain acyl-CoA oxidation defect. | 1991 | Lancet | pmid:1683940 |
| Qureshi IA et al. | Breeding experiments to combine the X-linked sparse-fur (spf) mutation with the autosomal recessive BALB/cByJ strain: testing the biochemical phenotype of double-mutant mice as a model for ammonia: fatty acyl CoA synergism. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8461026 |
| Lehnert W and Ruitenbeek W | Ethylmalonic aciduria associated with progressive neurological disease and partial cytochrome c oxidase deficiency. | 1993 | J. Inherit. Metab. Dis. | pmid:7609451 |
| Ballard CG et al. | Eating disorder in a 6-year-old Asian girl with ethyl malonic adipic aciduria. | 1993 | Int J Eat Disord | pmid:8477295 |
| Cheav SL et al. | [Synthesis and pharmacological activity of ethyl N-acetic and N-malonic esters of heterocyclic derivatives]. | 1993 | Ann Pharm Fr | pmid:8215120 |
| Sewell AC et al. | A new case of short-chain acyl-CoA dehydrogenase deficiency with isolated ethylmalonic aciduria. | 1993 | Eur. J. Pediatr. | pmid:8276024 |
| Garavaglia B et al. | Muscle cytochrome c oxidase deficiency in two Italian patients with ethylmalonic aciduria and peculiar clinical phenotype. | 1994 | J. Inherit. Metab. Dis. | pmid:7807937 |
| Kristensen MJ et al. | Amino acid polymorphism (Gly209Ser) in the ACADS gene. | 1994 | Hum. Mol. Genet. | pmid:7833941 |