Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid:28930667 | ||||
Tutor JC et al. | Urinary excretion of D-glucaric acid in porphyria cutanea tarda. | 1987 | J. Clin. Chem. Clin. Biochem. | pmid:2895161 |
Nomoto H et al. | A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report. | 2017 | Medicine (Baltimore) | pmid:28953654 |
Tutor JC et al. | Urinary D-glucaric acid and serum hepatic enzyme levels in chronic alcoholics. | 1988 | Clin. Biochem. | pmid:2898981 |
pmid:29027212 | ||||
pmid:29138559 | ||||
Adzharov D et al. | [Effects of preliminary fasting on the development of D-galactosamine-induced acute lesion of the liver in rats]. | 1989 | Biull Eksp Biol Med | pmid:2914170 |
pmid:29168243 | ||||
Macfadyen A and Ho KJ | D-glucaro-1,4-lactone: its excretion in the bile and urine and effect on the biliary secretion of beta-glucuronidase after oral administration in rats. | 1989 | Hepatology | pmid:2925160 |
Abou-Issa HM et al. | Putative metabolites derived from dietary combinations of calcium glucarate and N-(4-hydroxyphenyl)retinamide act synergistically to inhibit the induction of rat mammary tumors by 7,12-dimethylbenz[a]anthracene. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2967969 |
Brewster MA | Biomarkers of xenobiotic exposures. | 1988 Jul-Aug | Ann. Clin. Lab. Sci. | pmid:3044268 |
Kolmodin-Hedman B | Enzyme induction: its relevance for internal exposure and health risks. | 1988 | Int Arch Occup Environ Health | pmid:3049388 |
Walaszek Z et al. | Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. | 1986 | Carcinogenesis | pmid:3091283 |
Dwivedi C et al. | Net glucuronidation in different rat strains: importance of microsomal beta-glucuronidase. | 1987 | FASEB J. | pmid:3115856 |
Dwivedi C et al. | Effect of dietary calcium glucarate on 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in CD-1 mice. | 1988 Nov-Dec | Cleve Clin J Med | pmid:3147822 |
Volpi R et al. | [Increased urinary excretion of D-glucaric acid in workers exposed to styrene in reinforced plastics industry]. | 1988 Mar-Apr | Med Lav | pmid:3173231 |
Mocarelli P et al. | A new method for D-glucaric acid excretion measurement that is suitable for automated instruments. | 1988 | Clin. Chem. | pmid:3180424 |
Matsushiro T et al. | Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones. | 1977 | Gastroenterology | pmid:320083 |
Walaszek Z et al. | Repression by sustained-release beta-glucuronidase inhibitors of chemical carcinogen-mediated induction of a marker oncofetal protein in rodents. | 1988 | J Toxicol Environ Health | pmid:3336058 |
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Kinouchi T et al. | In vitro intestinal microflora-mediated metabolism of biliary metabolites from 1-nitropyrene-treated rats. | 1987 | Microbiol. Immunol. | pmid:3451027 |
Ohnhaus EE et al. | Effect of enzyme induction on plasma lipids using antipyrine, phenobarbital, and rifampicin. | 1979 | Clin. Pharmacol. Ther. | pmid:35298 |
Ohnhaus EE and Park BK | Measurement of urinary 6-beta-hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenobarbitone and rifampicin. | 1979 | Eur. J. Clin. Pharmacol. | pmid:35353 |
Price DE et al. | The effect of low-dose phenobarbitone on three indices of hepatic microsomal enzyme induction. | 1986 | Br J Clin Pharmacol | pmid:3567022 |
Sandle LN and Braganza JM | An evaluation of the low-pH enzymatic assay of urinary D-glucaric acid, and its use as a marker of enzyme induction in exocrine pancreatic disease. | 1987 | Clin. Chim. Acta | pmid:3568402 |
Taccone-Gallucci M et al. | Risk of iron overload and 'hemochromatosis allele(s)' in patients on maintenance hemodialysis. | 1987 | Am. J. Nephrol. | pmid:3578371 |
Heinemeyer G et al. | Kinetics of hexobarbital and dipyrone in critical care patients receiving high-dose pentobarbital. | 1987 | Eur. J. Clin. Pharmacol. | pmid:3595700 |
Horváth T et al. | Disorders of biotransformation during the progression of alcoholic liver disease. | 1986 | Acta Med Hung | pmid:3601579 |
Oyabu H et al. | Nonbacterial transformation of bilirubin in bile. | 1987 | Dig. Dis. Sci. | pmid:3608728 |
Oredipe OA et al. | Effects of calcium glucarate on the promotion of diethylnitrosamine-initiated altered hepatic foci in rats. | 1987 | Cancer Lett. | pmid:3690519 |
Kawahara K et al. | Urinary excretion of conjugates of dothiepin and northiaden (mono-N-demethyl-dothiepin) after an oral dose of dothiepin to humans. | 1986 Jan-Mar | Eur J Drug Metab Pharmacokinet | pmid:3720795 |
Gachályi B et al. | [Effect of alpha methyldopa on the mixed oxygenase system of the liver in man]. | 1979 | Orv Hetil | pmid:372883 |
Traeger A et al. | Beta-adrenoceptor blocking drugs and cytochrome P-450: the influence of propranolol treatment on caffeine, antipyrine, D-glucaric acid and indocyanine green elimination in patients with hepatic disorders. | 1986 | Int J Clin Pharmacol Res | pmid:3744626 |
Steinberg KK and Needham LL | A comparison of two methods for quantifying D-glucaric acid. | 1986 Jul-Aug | J Anal Toxicol | pmid:3747452 |
Nakajima M et al. | A solid-phase substrate of heparanase: its application to assay of human melanoma for heparan sulfate degradative activity. | 1986 | Anal. Biochem. | pmid:3766958 |
Walaszek Z et al. | Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis. | 1986 | Cancer Lett. | pmid:3768860 |
Marsh CA | Biosynthesis of D-glucaric acid in mammals: a free-radical mechanism? | 1986 | Carbohydr. Res. | pmid:3779687 |
Perry W and Jenkins MV | Note on the enzyme assay for urinary D-glucaric acid and correlation with rifampicin-induced mixed function oxidase activity. | 1986 | Int J Clin Pharmacol Ther Toxicol | pmid:3793294 |
Balázová E et al. | Antitumor activity of four polymer bound trans-1,2-diaminocyclohexaneplatinum(II)-4-carboxyphtalate complexes tested in different model systems. | 1986 | Neoplasma | pmid:3808121 |
Couvaris M et al. | Comparative study of the effects of some inducers with or without protein binding properties on bioavailability of isoxazolylpenicillins in rats. | 1986 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:3816874 |
Gachályi B et al. | Pharmacogenetic differences in the inhibitory effect of cimetidine on the metabolism of antipyrine. | 1987 | Eur. J. Clin. Pharmacol. | pmid:3830247 |
Oxley J et al. | Lack of hepatic enzyme inducing effect of sodium valproate. | 1979 | Br J Clin Pharmacol | pmid:385027 |
Marsh CA | An enzymatic determination of D-glucaric acid by conversion to pyruvate. | 1985 | Anal. Biochem. | pmid:3893213 |
Hopwood JJ and Muller V | Biochemical discrimination of Hurler and Scheie syndromes. | 1979 | Clin. Sci. | pmid:38945 |
Pasquini R et al. | Mutagenicity studies and D-glucaric acid determination in urine of workers exposed to mineral oils. | 1985 | Int Arch Occup Environ Health | pmid:3905625 |
Micheletti C et al. | [Enzymatic induction during isoniazid therapy (author's transl)]. | 1979 | Pathol. Biol. | pmid:392418 |
van Soesbergen RM et al. | Bone metabolism in rheumatoid arthritis compared with postmenopausal osteoporosis. | 1986 | Ann. Rheum. Dis. | pmid:3947143 |
MacNeil ML et al. | A semiautomated procedure for urinary D-glucaric acid using a centrifugal analyzer. | 1986 Jan-Feb | J Anal Toxicol | pmid:3951202 |
George S et al. | The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen. | 1986 | Eur. J. Clin. Pharmacol. | pmid:3956563 |
Gigon PL and Bickel MH | Interference of UDP-glucuronyltransferase and beta-glucuronidase activity in rat liver microsomes at pH 7.5 with p-nitrophenol and p-nitrophenylglucuronide as substrates. | 1979 | Enzyme | pmid:39749 |