Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
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Authors | Title | Published | Journal | PubMed Link |
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Davidson DC et al. | Assessment of plasma glutamyl transpeptidase activity and urinary D-glucaric acid excretion as indices of enzyme induction. | 1974 | Clin Sci Mol Med | pmid:4154014 |
Edwards OM et al. | Changes in cortisol metabolism following rifampicin therapy. | 1974 | Lancet | pmid:4140269 |
Smirne S et al. | [Serum gamma-glutamyl-transpeptidase and urinary excretion of D-glucaric acid in epileptic patients treated with anticonvulsants]. | 1974 Jul-Aug | Riv Neurol | pmid:4155805 |
Murchison LE et al. | Effects of anticonvulsants and inactivity on bone disease in epileptics. | 1975 | Postgrad Med J | pmid:1161672 |
Cassimos C et al. | Urinary D-glucaric acid excretion in children with dystonic reactions caused by antiemetic drugs. | 1975 | J. Pediatr. | pmid:1185409 |
Marselos M et al. | Evidence that D-glucaro-1,4-lactone shortens the pharmacological action of drugs being disposed via the bile as glucuronides. | 1975 | Biochem. Pharmacol. | pmid:1191334 |
Talafant E et al. | Glucaric acid excretion as index of hepatic glucuronidation in neonates after phenobarbital treatment. | 1975 | Pediatr. Res. | pmid:1134846 |
Levy G et al. | Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. | 1975 | Pediatrics | pmid:1134883 |
Lecamwasam DS | Hepatic enzyme induction and its relationship to urinary D-glucaric acid excretion in man. | 1975 | Br J Clin Pharmacol | pmid:1234021 |
Lecamwasam DS et al. | Effect of phenobarbitone on hepatic drug-metabolizing enzymes and urinary D-glucaric acid excretion in man. | 1975 | Br J Clin Pharmacol | pmid:1234506 |
Kaizu T | [Non-dialyzable beta-glucuronidase inhibitor in guinea-pig urine. I. Purification (author's transl)]. | 1975 | Yakugaku Zasshi | pmid:1238533 |
Tokola O et al. | Hepatic drug-oxidizing enzyme systems and urinary D-glucaric acid excretion in patients with congestive heart failure. | 1975 | Br J Clin Pharmacol | pmid:786355 |
Hildebrandt AG et al. | Evaluation of in vivo parameters of drug metabolizing enzyme activity in man after administration of clemastine, phenobarbital or placebo. | 1975 | Eur. J. Clin. Pharmacol. | pmid:9297 |
Street JC and Chadwick RW | Ascorbic acid requirements and metabolism in relation to organochlorine pesticides. | 1975 | Ann. N. Y. Acad. Sci. | pmid:54013 |
Spencer-Peet J et al. | Urinary d-glucaric acid excretion and serum gamma-glutamyl transpeptidase activity in alcoholism. | 1975 | Br J Addict Alcohol Other Drugs | pmid:2272 |
Malaka-Zafiriu K et al. | D-Glucaric acid excretion in newborns with severe jaundice of unknown etiology and due to glucose-6-phosphate dehydrogenase deficiency in Greece. | 1975 | Helv Paediatr Acta | pmid:807541 |
Marselos M et al. | Aldehyde dehydrogenase inducibility and ethanol preference in rats. | 1975 | Med. Biol. | pmid:810629 |
Marselos M and Laitinen M | Starvation and phenobarbital treatment effects on drug hydroxylation and glucuronidation in the rat liver and small intestinal mucosa. | 1975 | Biochem. Pharmacol. | pmid:811226 |
Latham AN | Effect of in vitro changes in urinary pH on the enzymatic measurement and daily variation in excretion of D-glucaric acid. | 1975 | J. Pharm. Pharmacol. | pmid:239180 |
Roots I et al. | Comparison of methods to study enzyme induction in man. | 1975 | Adv. Exp. Med. Biol. | pmid:239546 |
Matsuo E et al. | Acid mucopolysaccharide metabolism in leprosy. 3. Hyaluronic acid mycobacterial growth enhancement, and growth suppression by saccharic acid and vitamin C as inhibitors of beta-glucuronidase. | 1975 Jan-Mar | Int. J. Lepr. Other Mycobact. Dis. | pmid:1099016 |
Oka H et al. | Increased urinary excretion of L-xylulose in patients with liver cirrhosis. | 1976 | Clin. Chim. Acta | pmid:1248150 |
Escartin Marin P et al. | [Enzyme induction in alcoholic and cryptogenetic cirrhoses]. | 1976 | Rev Esp Enferm Apar Dig | pmid:1257561 |
McLean AE | Cancer and nutrition (review). | 1976 | Nahrung | pmid:781541 |
Bartels H et al. | [Relations between lipoprotein X and gamma glutamyltransferase in serum and D-saccharic acid in urine of mature, healthy newborn infants]. | 1976 | Monatsschr Kinderheilkd | pmid:6906 |
Talafant E et al. | Serum gamma-glutamyl transpeptidase activity and urinary D-glucaric acid excretion in newborns in the first week of life. Effects of phenobarbital and nicethamide combination. | 1976 | Acta Paediatr Scand | pmid:11634 |
Hornez JP et al. | [Demonstration of different metabolic pathways starting with glucose or fructose in Rhizobium meliloti]. | 1976 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:11894 |
Wagner G and Hollmann S | Uronic acid dehydrogenase from Pseudomonas syringae. Purification and properties. | 1976 | Eur. J. Biochem. | pmid:2471 |
Marselos M | Genetic variation of drug-metabolizing enzymes in the wistar rat. | 1976 | Acta Pharmacol Toxicol (Copenh) | pmid:821309 |
Hoffmann D | [Role of phagocytosis and soluble antibacterial factors in experimental immunization of Locusta migratoria]. | 1976 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:821627 |
Sorrell MF et al. | Paradoxical urinary excretion of D-glucaric acid in acute viral hepatitis. | 1976 | Clin. Pharmacol. Ther. | pmid:954355 |
Roberts C et al. | Glutethimide and enzyme induction. | 1976 | Br Med J | pmid:990872 |
Latham AN et al. | Phenobarbitone-induced urinary excretions of D-glucaric acid and 6beta-hydroxycortisol in man. | 1976 | Can. J. Physiol. Pharmacol. | pmid:991005 |
Furuno K et al. | Preventive effect of D-glucarate against renal damage induced by kanamycin. | 1976 | J. Antibiot. | pmid:993134 |
Furuno K et al. | Effect of D-Glucarates on basic antibiotic-induced renal damage in rats. | 1976 | J. Antibiot. | pmid:931801 |
Mezey E | Increased urinary excretion of D-glucaric acid in alcoholism. | 1976 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1005917 |
Latham AN and Sweeney GD | Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of induction of hepatic microsomal enzymes. | 1976 | Can. J. Physiol. Pharmacol. | pmid:1021219 |
Düllmann J et al. | [Iron storage and metabolism in nacrophages and endothelial cells after intravenous administration of colloidal ferric saccharate in man]. | 1976 | Verh Anat Ges | pmid:1024396 |
Rycroft D and Daniel JW | The excretion of D-glucaric acid in the urine of human volunteers following the administration of disopyramide. | 1976 | J. Int. Med. Res. | pmid:1026531 |
Cassimos C et al. | Erythrocyte glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice. | 1977 | Acta Paediatr Scand | pmid:868519 |
Fujihira E and Whitehouse MW | Pathobiodynamics: reduced ascorbate excretion by rats with severe inflammation. | 1977 | Proc. Soc. Exp. Biol. Med. | pmid:877135 |
Kawasaki H et al. | Effect of corticosteroid treatment on bilirubin metabolism in chronic aggressive hepatitis. | 1977 | Acta Hepatogastroenterol (Stuttg) | pmid:883466 |
Talafant E et al. | Negative feedback control of neonatal serum creatine and increased urinary creatinine excretion after enzyme-inducing drugs. | 1977 | Pediatr. Res. | pmid:887306 |
Roth B et al. | [Excretion of D-glucaric-acid in newborns with non-hemolytic hyperbilirubinemia after phenobarbital treatment (author's transl)]. | 1977 | Padiatr Padol | pmid:904946 |
Furuno K et al. | Influence of dehydration and D-glucarate on distribution and excretion of kanamycin in rats. | 1977 | Jpn. J. Pharmacol. | pmid:916384 |
Siest G et al. | [Biological tests as indirect indicators of the activity of drug metabolizing enzymes. Use of glucaric acid and gamma-glutamyltransferase]. | 1977 | Ann. Biol. Clin. (Paris) | pmid:28055 |
Herzberg M et al. | D-Glucaric acid and gamma-glutamyltransferase as indices of hepatic enzyme induction in pregnancy. | 1977 | Clin. Chem. | pmid:13946 |
Matsushiro T et al. | Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones. | 1977 | Gastroenterology | pmid:320083 |
Notten WR and Henderson PT | The interaction of chemical compounds with the functional state of the liver. II. Estimation of changes in D-glucaric acid synthesis as a method for diagnosing exposure to xenobiotics. | 1977 | Int Arch Occup Environ Health | pmid:832915 |
Arató M and Varadi A | On the possible role of enzyme induction in cases of resistancy to chlorpromazine treatment. | 1977 | Pharmakopsychiatr Neuropsychopharmakol | pmid:616930 |