Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Balázová E et al. | Antitumor activity of four polymer bound trans-1,2-diaminocyclohexaneplatinum(II)-4-carboxyphtalate complexes tested in different model systems. | 1986 | Neoplasma | pmid:3808121 |
Hrubisko M et al. | Drug resistance induction and cross-resistance studies with Pt-complexes. | 1984 | Neoplasma | pmid:6542968 |
Fernández-Gallego J et al. | [Treatment with intravenous iron and ferritin level]. | 2010 | Nefrologia | pmid:20514109 |
Faber F et al. | Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. | 2016 | Nature | pmid:27309805 |
Dueber JE et al. | Synthetic protein scaffolds provide modular control over metabolic flux. | 2009 | Nat. Biotechnol. | pmid:19648908 |
DeLisa MP and Conrado RJ | Synthetic metabolic pipelines. | 2009 | Nat. Biotechnol. | pmid:19668178 |
Gomollón F and Gisbert JP | IBD: Intravenous iron in IBD--what's the best preparation? | 2011 | Nat Rev Gastroenterol Hepatol | pmid:21788975 |
McLean AE | Cancer and nutrition (review). | 1976 | Nahrung | pmid:781541 |
Auerbach M and Rodgers GM | Intravenous iron. | 2007 | N. Engl. J. Med. | pmid:17611217 |
Kriebel D et al. | Detection of occupational exposure to genotoxic agents with a urinary mutagen assay. | 1983 | Mutat. Res. | pmid:6835232 |
Scassellati-Sforzolini G et al. | In vivo studies on genotoxicity of pure and commercial linuron. | 1997 | Mutat. Res. | pmid:9186570 |
Grote L et al. | A randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome. | 2009 | Mov. Disord. | pmid:19489063 |
Richens A et al. | Effects of sodium valproate on the serum protein binding of phenytoin, and on liver enzyme activity. | 1980 | Monogr Neural Sci | pmid:6798427 |
Bartels H et al. | [Relations between lipoprotein X and gamma glutamyltransferase in serum and D-saccharic acid in urine of mature, healthy newborn infants]. | 1976 | Monatsschr Kinderheilkd | pmid:6906 |
Xia B et al. | A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. | 2012 | Mol. Pharm. | pmid:23033922 |
Li LO et al. | Early hepatic insulin resistance in mice: a metabolomics analysis. | 2010 | Mol. Endocrinol. | pmid:20150186 |
Sienkiewicz-Porzucek A et al. | Mild reductions in mitochondrial NAD-dependent isocitrate dehydrogenase activity result in altered nitrate assimilation and pigmentation but do not impact growth. | 2010 | Mol Plant | pmid:20035036 |
Menendez C et al. | Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed? | 2011 | Mol Nutr Food Res | pmid:22144045 |
Wyffels L et al. | Detection of myocardial ischemia-reperfusion injury using a fluorescent near-infrared zinc(II)-dipicolylamine probe and 99mTc glucarate. | 2012 | Mol Imaging | pmid:22554483 |
Biggar P and Hahn KM | [Importance of the different i.v. iron generations for everyday medical practice]. | 2013 | MMW Fortschr Med | pmid:23678667 |
Kosch M and Schaefer RM | [Iron deficiency. When parenteral substitution?]. | 2001 | MMW Fortschr Med | pmid:11247361 |
Filisetti P et al. | [D-glucaric acid. A new method proposed to investigate damage from exposure to anesthetic gas and vapors]. | 1990 | Minerva Anestesiol | pmid:2084591 |
Teschke O et al. | Quorum sensing detected by atomic force microscopy imaging of corrals surrounding multicellular arrangement of bacteria. | 2008 | Microsc. Res. Tech. | pmid:17943987 |
Kinouchi T et al. | In vitro intestinal microflora-mediated metabolism of biliary metabolites from 1-nitropyrene-treated rats. | 1987 | Microbiol. Immunol. | pmid:3451027 |
De Saint-Hubert M et al. | Molecular imaging of cell death. | 2009 | Methods | pmid:19362149 |
Moon TS et al. | Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli. | 2010 | Metab. Eng. | pmid:20117231 |
De Sousa A and Kalra G | Drug therapy of attention deficit hyperactivity disorder: current trends. | 2012 | Mens Sana Monogr | pmid:22654382 |
Nomoto H et al. | A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report. | 2017 | Medicine (Baltimore) | pmid:28953654 |
Deng Y et al. | Efficacy of Intravenous Iron Sucrose in Hemodialysis Patients with Restless Legs Syndrome (RLS): A Randomized, Placebo-Controlled Study. | 2017 | Med. Sci. Monit. | pmid:28285317 |
Ren X et al. | Effect of Intravenous Iron Supplementation on Acute Mountain Sickness: A Preliminary Randomized Controlled Study. | 2015 | Med. Sci. Monit. | pmid:26175087 |
Hedenus M and Birgegård G | The role of iron supplementation during epoietin treatment for cancer-related anemia. | 2009 | Med. Oncol. | pmid:18473194 |
Séronie-Vivien S et al. | Epoetin alfa and intravenous iron sucrose to treat severe anemia in a patient with chronic radiation enteropathy: a case report. | 2003 | Med. Oncol. | pmid:14514981 |
Marselos M et al. | Aldehyde dehydrogenase inducibility and ethanol preference in rats. | 1975 | Med. Biol. | pmid:810629 |
Franco G et al. | Behaviour of urinary D-glucaric acid excretion in surgical patients and anaesthesiology staff acutely exposed to isoflurane and nitrous oxide. | 1991 Nov-Dec | Med Lav | pmid:1803214 |
Maroni M et al. | Evaluation of porphyrinogenesis and enzyme induction in workers exposed to PCB. | 1984 May-Jun | Med Lav | pmid:6148686 |
Loi AM et al. | [Urinary secretion of D-glucaric acid in subjects exposed to styrene]. | 1984 Mar-Apr | Med Lav | pmid:6749047 |
Volpi R et al. | [Increased urinary excretion of D-glucaric acid in workers exposed to styrene in reinforced plastics industry]. | 1988 Mar-Apr | Med Lav | pmid:3173231 |
Apostoli P et al. | [Behavior of urinary D-glucaric acid in occupational exposure to inorganic lead]. | 1987 Sep-Oct | Med Lav | pmid:3447026 |
Tutor JC et al. | [Calcium metabolism and liver enzyme induction in patients treated with anticonvulsant drugs]. | 1984 | Med Clin (Barc) | pmid:6145829 |
GarcÃa Erce JA et al. | [Thoughts about the usefulness of the preoperatory administration of intravenous iron in hip fracture surgery]. | 2013 | Med Clin (Barc) | pmid:23790583 |
Blanco Rubio N et al. | [Preoperative intravenous iron as a strategy for blood saving in surgery for hip fracture]. | 2013 | Med Clin (Barc) | pmid:23246172 |
Muñoz M et al. | [Usefulness of the administration of intravenous iron sucrose for the correction of preoperative anemia in major surgery patients]. | 2009 | Med Clin (Barc) | pmid:19264195 |
Izuel Rami M et al. | [Budget impact analysis of a blood saving program for urgent traumatological surgery]. | 2007 | Med Clin (Barc) | pmid:17266885 |
Fujita K et al. | Establishment of Salmonella strain expressing catalytically active human UDP-glucuronosyltransferase 1A1 (UGT1A1). | 2000 | Life Sci. | pmid:10821120 |
Brunelle FM and Verbeeck RK | Conjugation-deconjugation cycling of diflunisal via beta-glucuronidase catalyzed hydrolysis of its acyl glucuronide in the rat. | 1997 | Life Sci. | pmid:9180355 |
Curley RW et al. | Activity of D-glucarate analogues: synergistic antiproliferative effects with retinoid in cultured human mammary tumor cells appear to specifically require the D-glucarate structure. | 1994 | Life Sci. | pmid:8190001 |
Budillon G et al. | D-glucaric acid excretion during chenodeoxycholate therapy for gallstones. | 1978 | Lancet | pmid:74626 |
de Wolff FA et al. | Valproate induces urinary D-glucaric acid excretion. | 1981 | Lancet | pmid:6111706 |
Hunter J et al. | Urinary D-glucaric-acid excretion as a test for hepatic enzyme induction in man. | 1971 | Lancet | pmid:4100904 |
Aarts EM | D-glucaric-acid excretion as a test for hepatic enzyme induction. | 1971 | Lancet | pmid:4102545 |
Hunter J et al. | D-glucaric-acid excretion as a test for hepatic enzyme induction. | 1971 | Lancet | pmid:4103690 |
Edwards OM et al. | Changes in cortisol metabolism following rifampicin therapy. | 1974 | Lancet | pmid:4140269 |
Krafft A et al. | Erythropoietic quality of maternal milk. | 1999 | Lancet | pmid:10475225 |
Hu Q et al. | Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. | 2010 | Lab. Invest. | pmid:20065947 |
Yoon J et al. | Postoperative high-dose intravenous iron sucrose with low dose erythropoietin therapy after total hip replacement. | 2010 | Korean J. Intern. Med. | pmid:21179286 |
Okada M et al. | Hypophosphatemia induced by intravenous administration of Saccharated iron oxide. | 1983 | Klin. Wochenschr. | pmid:6843038 |
Blaustein DA et al. | The safety and efficacy of an accelerated iron sucrose dosing regimen in patients with chronic kidney disease. | 2003 | Kidney Int. Suppl. | pmid:14531777 |
Keven K et al. | Combination of intravenous iron sucrose and ascorbic acid in hemodialysis patients. | 2005 | Kidney Int. | pmid:15954940 |
Agarwal R | Is i.v. iron really superior in CKD patients not on dialysis? | 2006 | Kidney Int. | pmid:16957750 |
Zager RA | Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy. | 2005 | Kidney Int. | pmid:16164630 |
Agarwal R | Proinflammatory effects of iron sucrose in chronic kidney disease. | 2006 | Kidney Int. | pmid:16609688 |
Deicher R et al. | High-dose parenteral iron sucrose depresses neutrophil intracellular killing capacity. | 2003 | Kidney Int. | pmid:12846772 |
Agarwal R | Transferrin saturation with intravenous irons: an in vitro study. | 2004 | Kidney Int. | pmid:15327409 |
Aronoff GR et al. | Iron sucrose in hemodialysis patients: safety of replacement and maintenance regimens. | 2004 | Kidney Int. | pmid:15327417 |
Zager RA et al. | Parenteral iron nephrotoxicity: potential mechanisms and consequences. | 2004 | Kidney Int. | pmid:15200421 |
Sengoelge G et al. | Dose-dependent effect of parenteral iron therapy on bleomycin-detectable iron in immune apheresis patients. | 2004 | Kidney Int. | pmid:15200437 |
Zager RA et al. | Combined iron sucrose and protoporphyrin treatment protects against ischemic and toxin-mediated acute renal failure. | 2016 | Kidney Int. | pmid:27165818 |
Agarwal R et al. | A randomized trial of intravenous and oral iron in chronic kidney disease. | 2015 | Kidney Int. | pmid:26083656 |
Vikrant S | Optimum dosage regimen for iron sucrose. | 2007 | Kidney Int. | pmid:17625585 |
Agarwal R et al. | Iron sucrose causes greater proteinuria than ferric gluconate in non-dialysis chronic kidney disease. | 2007 | Kidney Int. | pmid:17622274 |
Jaber BL | Iron sucrose causes greater proteinuria than ferric gluconate in non-dialysis chronic kidney disease. | 2008 | Kidney Int. | pmid:18235527 |
Lim R et al. | A permanent tan from iron. | 2008 | Kidney Int. | pmid:18340355 |
Auerbach M and Al Talib K | Low-molecular weight iron dextran and iron sucrose have similar comparative safety profiles in chronic kidney disease. | 2008 | Kidney Int. | pmid:18274543 |
Schaller G et al. | Intravenous iron increases labile serum iron but does not impair forearm blood flow reactivity in dialysis patients. | 2005 | Kidney Int. | pmid:16316358 |
Van Wyck DB et al. | A randomized, controlled trial comparing IV iron sucrose to oral iron in anemic patients with nondialysis-dependent CKD. | 2005 | Kidney Int. | pmid:16316362 |
Zheng H et al. | Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects. | 2006 | Kidney Int. | pmid:16395269 |
Almilaji A et al. | Regulation of the voltage gated K channel Kv1.3 by recombinant human klotho protein. | 2014 | Kidney Blood Press. Res. | pmid:25571875 |
Tanaka H et al. | [A growth media of genus Legionella in containing saccharated ferric oxide (Fesin) replacing soluble ferric pyrophosphate (author's transl)]. | 1982 | Kansenshogaku Zasshi | pmid:6809855 |
Higashi T et al. | [Relative Ga-67 image enhancement by iron-loading]. | 1984 | Kaku Igaku | pmid:6593479 |
Furuno K et al. | Influence of dehydration and D-glucarate on distribution and excretion of kanamycin in rats. | 1977 | Jpn. J. Pharmacol. | pmid:916384 |
Furuno K et al. | Effect of D-glucaric acid derivatives on stability of rat liver lysosomes and erythrocytes. | 1974 | Jpn. J. Pharmacol. | pmid:4463271 |
Hinohara Y et al. | Glucuronic acid pathway in alloxan diabetic rabbits. (I). Urinary excretion of metabolites related to the glucuronic acid pathway. | 1974 | Jpn. J. Pharmacol. | pmid:4463273 |
Tsuruoka T et al. | Inhibition of pulmonary metastases and tumor cell invasion in experimental tumors by sodium D-glucaro-delta-lactam (ND2001). | 1995 | Jpn. J. Cancer Res. | pmid:7737908 |
Tsuruoka T et al. | Inhibition of tumor cell haptotaxis by sodium D-glucaro-delta-lactam (ND2001). | 1995 | Jpn. J. Cancer Res. | pmid:8567400 |
Adhikary L and Acharya S | Efficacy of IV iron compared to oral iron for increment of haemoglobin level in anemic chronic kidney disease patients on erythropoietin therapy. | 2011 Jul-Sep | JNMA J Nepal Med Assoc | pmid:22922860 |
Smith TG et al. | Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. | 2009 | JAMA | pmid:19809026 |
Lynn S and McDaniel J | Managing severe anemia when the patient is a Jehovah's Witness. | 2013 | JAAPA | pmid:23610833 |
Gorder V et al. | Treatment of restless legs syndrome with iron infusion therapy. | 2009 | JAAPA | pmid:19354112 |
Yamamoto S et al. | Iatrogenic osteomalacia: report of two cases. | 2013 | J. UOEH | pmid:23475021 |
Wang Y et al. | Hepatoprotective effects of kombucha tea: identification of functional strains and quantification of functional components. | 2014 | J. Sci. Food Agric. | pmid:23716136 |
Kaltwasser JP et al. | Effect of recombinant human erythropoietin and intravenous iron on anemia and disease activity in rheumatoid arthritis. | 2001 | J. Rheumatol. | pmid:11708414 |
Kolodziejczyk J et al. | In vitro study of the antioxidative properties of the glucose derivatives against oxidation of plasma components. | 2011 | J. Physiol. Biochem. | pmid:21086198 |
Tutor-Crespo MJ et al. | Effect of antiepileptic drugs on the urinary excretion of porphyrins in non-porphyric subjects. | 2005 | J. Pharmacol. Sci. | pmid:16314692 |
Bologa M et al. | Pregnancy-induced changes in drug metabolism in epileptic women. | 1991 | J. Pharmacol. Exp. Ther. | pmid:2033516 |
Patel IH et al. | Induction effect of phenobarbital on the carbamazepine to carbamazepine-10, 11-epoxide pathway in rhesus monkeys. | 1981 | J. Pharmacol. Exp. Ther. | pmid:7229992 |
Tanaka E et al. | Studies on the trimethadione metabolism as a tool for the assessment of drug-metabolizing capacity using plasma and urine of rats pretreated with phenobarbital and 3-methylcholanthrene. | 1982 | J. Pharmacobio-dyn. | pmid:7097483 |
Garnham JC et al. | The effect of repeated administration of diftalone on enzyme induction. | 1978 | J. Pharm. Pharmacol. | pmid:27604 |
Oleson L and Court MH | Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases. | 2008 | J. Pharm. Pharmacol. | pmid:18718121 |
Latham AN | D-Glucaric acid as an index of hepatic enzyme induction by anticonvulsant drugs in man. | 1974 | J. Pharm. Pharmacol. | pmid:4151390 |
Latham AN | Effect of in vitro changes in urinary pH on the enzymatic measurement and daily variation in excretion of D-glucaric acid. | 1975 | J. Pharm. Pharmacol. | pmid:239180 |