Glucaric acid

Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glucaric acid?

Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glucaric acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Brain Ischemia D002545 89 associated lipids
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Hyperlipidemias D006949 73 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Parkinson Disease D010300 53 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Precancerous Conditions D011230 48 associated lipids
Leukemia P388 D007941 43 associated lipids
Occupational Diseases D009784 42 associated lipids
Hypotension D007022 41 associated lipids
Adenoma D000236 40 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Heart Failure D006333 36 associated lipids
Epilepsy D004827 35 associated lipids
Hyperplasia D006965 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Liver Diseases D008107 31 associated lipids
Kidney Diseases D007674 29 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Alcoholism D000437 27 associated lipids
Hyperinsulinism D006946 27 associated lipids
Anemia D000740 21 associated lipids
Myocardial Infarction D009203 21 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Tuberculosis, Pulmonary D014397 18 associated lipids
Peritoneal Neoplasms D010534 16 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Hypercalcemia D006934 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Critical Illness D016638 13 associated lipids
Carbon Tetrachloride Poisoning D002252 12 associated lipids
Hypocalcemia D006996 12 associated lipids
Hepatitis D006505 11 associated lipids
Per page 10 20 50 100 | Total 85

PubChem Associated disorders and diseases

What pathways are associated with Glucaric acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Glucaric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Glucaric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Glucaric acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with Glucaric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glucaric acid?

Knock-out

Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Glucaric acid

Download all related citations
Per page 10 20 50 100 | Total 1061
Authors Title Published Journal PubMed Link
Ohnhaus EE et al. The effect of antipyrine, phenobarbitol and rifampicin on thyroid hormone metabolism in man. 1981 Eur. J. Clin. Invest. pmid:6800809
Richens A et al. Effects of sodium valproate on the serum protein binding of phenytoin, and on liver enzyme activity. 1980 Monogr Neural Sci pmid:6798427
Matsuoka S et al. Correlation between the level of urinary D-glucaric acid and the degree of activation of masked compound (FT-207) in cancer patients. 1981 Tohoku J. Exp. Med. pmid:6797104
Németh I et al. Hyperbilirubinemia and urinary D-glucaric acid excretion in premature infants following antepartum dexamethasone treatment. 1981 J Perinat Med pmid:6783743
Gargan R et al. A concise biotyping system for differentiating strains of Escherichia coli. 1982 J. Clin. Pathol. pmid:6757274
Loi AM et al. [Urinary secretion of D-glucaric acid in subjects exposed to styrene]. 1984 Mar-Apr Med Lav pmid:6749047
Nakajima M et al. Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase. 1984 J. Biol. Chem. pmid:6698965
Freundt KJ Variable inhibition of human hepatic drug metabolizing enzymes by disulfiram. 1978 Int J Clin Pharmacol Biopharm pmid:669879
Gachályi B et al. m-Trifluoromethyl-alpha-ethylbenzhydrol: a new enzyme inducer. 1978 Eur. J. Clin. Pharmacol. pmid:668788
Vezekenyi Z et al. Human tolerance of flumecinol (Zixoryn, RGH-3332), its regime and dosage in healthy volunteers. 1983 Int J Clin Pharmacol Res pmid:6679516
Horváth T et al. Correlation between biochemical tests, parameters of drug elimination and hepatic enzyme induction in chronic liver diseases. 1983 Acta Med Hung pmid:6674914
Laakso EI et al. Determination of D-glucaric acid by high-performance liquid chromatography. 1983 J. Chromatogr. pmid:6668320
Soldato PD and Meli A Studies on the mechanism of fat-free diet (FFD) protection against indomethacin-induced intestinal ulcers. 1978 Proc. Soc. Exp. Biol. Med. pmid:662870
Isomatsu Y et al. [Clinical study on prophylaxis of diacetyl-glucaro-(1-4) (6-3) dilactone for recurrence of bladder cancer]. 1983 Gan To Kagaku Ryoho pmid:6614934
Dolara P et al. Enzyme induction in humans exposed to styrene. 1983 Ann Occup Hyg pmid:6614729
Higashi T et al. [Relative Ga-67 image enhancement by iron-loading]. 1984 Kaku Igaku pmid:6593479
Oberhaensli RD et al. Different actions of deferoxamine and iron on Ga-67 abscess detection in rats. 1984 J. Nucl. Med. pmid:6587029
Stevens PM et al. Urinary D-glucaric acid and oral contraceptives. 1978 Br J Clin Pharmacol pmid:656297
Wang CY and Hayashida S Enhancement by phenothiazine and 2,5-di-O-acetyl-D-glucosaccharo-(1,4)(6,3)-dilactone of bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide in rats. 1984 Cancer Lett. pmid:6548659
Hrubisko M et al. Drug resistance induction and cross-resistance studies with Pt-complexes. 1984 Neoplasma pmid:6542968
Freundt KJ et al. Concentrations of D-glucaric acid in human urine after repeated administration of pyrithioxine. 1984 Int J Clin Pharmacol Ther Toxicol pmid:6526537
Miyawaki M et al. Absorption of experimentally administered materials by the hepatopancreas cells of the crayfish, Procambarus clarki. 1984 Cell Biol. Int. Rep. pmid:6509562
Houin G and Tillement JP Clofibrate and enzymatic induction in man. 1978 Int J Clin Pharmacol Biopharm pmid:649234
Imamura K Effects of intravenous administration of iron preparations on the metabolism of phosphorus. Comparative study on 3 iron preparations. 1984 Fukuoka Igaku Zasshi pmid:6489911
Gachályi B et al. Effect of a non-steroid anti-inflammatory agent on the drug metabolizing activity of the human liver. 1984 Int J Clin Pharmacol Ther Toxicol pmid:6469424
Várkonyi A et al. Non-specific drug-metabolizing enzyme activity in Gilbert disease. 1984 Acta Med Hung pmid:6440117
Perucca E et al. A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. 1984 Br J Clin Pharmacol pmid:6435654
Fujita M et al. Cancer-associated alteration of beta-glucuronidase in human lung cancer: elevated activity and increased phosphorylation. 1984 Gan pmid:6432619
Walters DG et al. Direct determination of D-[U-14C] glucaric acid in urine by ion-exchange high-performance liquid chromatography. 1983 J. Chromatogr. pmid:6423654
Ryzewski CN and Malejka-Giganti D A novel assay of glucuronidation of C- and N-hydroxylated metabolites of the carcinogen N-2-fluorenylacetamide. 1983 Anal. Biochem. pmid:6408946
Horváth T et al. Investigation of biotransformation capacity in patients with chronic liver diseases by pharmacokinetic methods: experimental trials. 1984 Jul-Aug Pol J Pharmacol Pharm pmid:6396596
Kimbrough RD The epidemiology and toxicology of TCDD. 1984 Bull Environ Contam Toxicol pmid:6240288
Martin JV Lipid abnormalities in workers exposed to dioxin. 1984 Br J Ind Med pmid:6232943
pmid:6209078
Walaszek Z et al. Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumorigenesis by 2,5-di-O-acetyl-D-glucaro-1,4:6,3-dilactone, an in vivo beta-glucuronidase inhibitor. 1984 Carcinogenesis pmid:6202433
Carrella M et al. An evaluation of urinary D-glucaric acid excretion during acute hepatitis in man. 1978 Am J Dig Dis pmid:619622
Arató M and Varadi A On the possible role of enzyme induction in cases of resistancy to chlorpromazine treatment. 1977 Pharmakopsychiatr Neuropsychopharmakol pmid:616930
Guzelian PS et al. Liver structure and function in patients poisoned with chlordecone (Kepone). 1980 Gastroenterology pmid:6153073
Pár A et al. Inhibition of hepatic drug metabolism by (+)-cyanidanol-3 (Catergen) in chronic alcoholic liver disease. 1984 Acta Physiol Hung pmid:6152369
Maroni M et al. Evaluation of porphyrinogenesis and enzyme induction in workers exposed to PCB. 1984 May-Jun Med Lav pmid:6148686
Jung K and Scholz D Increased serum gamma-glutamyltransferase activity in renal transplant recipients: liver damage or microsomal enzyme induction? 1984 Clin. Chim. Acta pmid:6147212
Tutor JC et al. [Calcium metabolism and liver enzyme induction in patients treated with anticonvulsant drugs]. 1984 Med Clin (Barc) pmid:6145829
Perry W and Stamp TC Urinary D-glucaric acid excretion during rifampicin/isoniazid and anticonvulsant enzyme induction. 1984 Clin. Pharmacol. Ther. pmid:6143635
Døssing M Noninvasive assessment of microsomal enzyme activity in occupational medicine: present state of knowledge and future perspectives. 1984 Int Arch Occup Environ Health pmid:6142865
Peduto VA et al. Stimulation of drug-metabolizing enzymes by nitrous oxide in the rat. 1983 Acta Anaesthesiol Scand pmid:6141696
de Wolff FA et al. The effects of valproic acid on liver function. 1983 Arch. Toxicol. Suppl. pmid:6138013
Wright JH et al. Hepatic enzyme induction patterns and phenothiazine side effects. 1983 Clin. Pharmacol. Ther. pmid:6137306
Kawasaki H et al. Effects of phenobarbital on unconjugated bilirubin clearance, gamma-glutamyltranspeptidase and urinary d-glucaric acid in patients with Gilbert's syndrome. 1982 Hepatogastroenterology pmid:6130037
Park BK Assessment of the drug metabolism capacity of the liver. 1982 Br J Clin Pharmacol pmid:6128018
Jung K et al. [D-glucaric acid excretion in kidney transplant patients as an indicator of microsomal enzyme capacity]. 1982 Z Urol Nephrol pmid:6126971