Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dwivedi C et al. | Modulation of chemically initiated and promoted skin tumorigenesis in CD-1 mice by dietary glucarate. | 1989 May-Jun | J. Environ. Pathol. Toxicol. Oncol. | pmid:2509679 |
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RICHTER GW | The cellular transformation of injected colloidal iron complexes into ferritin and hemosiderin in experimental animals; a study with the aid of electron microscopy. | 1959 | J. Exp. Med. | pmid:13620849 |
ELLIS JT | Glomerular lesions and the nephrotic syndrome in rabbits given saccharated iron oxide intravenously; with special reference to the part played by intracapillary precipitates in the pathogenesis of the lesions. | 1956 | J. Exp. Med. | pmid:13278460 |
Roberton AM et al. | Two genes affecting glucarate utilization in Escherichia coli K12. | 1980 | J. Gen. Microbiol. | pmid:6999115 |
Monsénégo J et al. | Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis. | 2012 | J. Hepatol. | pmid:22037024 |
Rycroft D and Daniel JW | The excretion of D-glucaric acid in the urine of human volunteers following the administration of disopyramide. | 1976 | J. Int. Med. Res. | pmid:1026531 |
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Abou-Issa H et al. | Chemotherapeutic evaluation of glucarate and N-(4-hydroxyphenyl)retinamide alone and in combination in the rat mammary tumor model. | 1989 | J. Natl. Cancer Inst. | pmid:2531231 |
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Kumbasar A et al. | The effect of different doses and types of intravenous iron on oxidative stress and inflammation in hemodialysis patients. | 2012 Sep-Oct | J. Nephrol. | pmid:22307439 |
Leijn E et al. | Intravenous iron supplementation in children on hemodialysis. | 2004 May-Jun | J. Nephrol. | pmid:15365964 |
Mariani G et al. | Detection of acute myocardial infarction by 99mTc-labeled D-glucaric acid imaging in patients with acute chest pain. | 1999 | J. Nucl. Med. | pmid:10565778 |
Yaoita H et al. | Localization of technetium-99m-glucarate in zones of acute cerebral injury. | 1991 | J. Nucl. Med. | pmid:1704054 |
Ballinger JR et al. | Effect of hypoxia on the accumulation of technetium-99m-glucarate and technetium-99m-gluconate by Chinese hamster ovary cells in vitro. | 1993 | J. Nucl. Med. | pmid:8381475 |
Orlandi C et al. | Early scintigraphic detection of experimental myocardial infarction in dogs with technetium-99m-glucaric acid. | 1991 | J. Nucl. Med. | pmid:1992031 |
Oberhaensli RD et al. | Different actions of deferoxamine and iron on Ga-67 abscess detection in rats. | 1984 | J. Nucl. Med. | pmid:6587029 |
Ohtani H et al. | Comparison of technetium-99m-glucarate and thallium-201 for the identification of acute myocardial infarction in rats. | 1992 | J. Nucl. Med. | pmid:1432160 |
Yaoita H et al. | Distribution of deoxyglucose and technetium-99m-glucarate in the acutely ischemic myocardium. | 1993 | J. Nucl. Med. | pmid:8326389 |