Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bolton CH et al. | Enzyme induction and serum and lipoprotein lipids: a study of glutethimide in normal subjects. | 1980 | Clin. Sci. | pmid:7389270 |
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Németh I and Szeleczki T | Increased D-glucaric acid excretion in children with renal disease. | 1980 | Int J Clin Pharmacol Ther Toxicol | pmid:7409939 |
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Fiedler K et al. | Glucaric acid excretion. Analysis of the enzymatic assay and findings in smokers and non-smokers. | 1980 | Eur. J. Clin. Pharmacol. | pmid:7439267 |
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Abou-Issa H et al. | Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. | 1995 May-Jun | Anticancer Res. | pmid:7645962 |
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Tokola O et al. | Hepatic drug-oxidizing enzyme systems and urinary D-glucaric acid excretion in patients with congestive heart failure. | 1975 | Br J Clin Pharmacol | pmid:786355 |
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Ciuffi M et al. | Effect of 21-aminosteroid U74500A (pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(5,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methyl-, HCl (16 alpha)) on rat brain cortex lipid peroxidation induced "in vivo" by iron-carbohydrate. | 1994 | Biochem. Pharmacol. | pmid:8031311 |
Previs SF et al. | Use of [6,6-2H2]glucose and of low-enrichment [U-13C6]-glucose for sequential or simultaneous measurements of glucose turnover by gas chromatography-mass spectrometry. | 1994 | Anal. Biochem. | pmid:8053553 |
Malaka-Zafiriu K et al. | D-Glucaric acid excretion in newborns with severe jaundice of unknown etiology and due to glucose-6-phosphate dehydrogenase deficiency in Greece. | 1975 | Helv Paediatr Acta | pmid:807541 |
Fujimoto T et al. | A new clinical prognostic predictor for patients with biliary atresia. | 1994 | J. Pediatr. Surg. | pmid:8078014 |
Mizumoto Y et al. | [Measurement and fluctuation of urinary glucaric acid in pregnant women]. | 1994 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:8089594 |
Sacco C et al. | Selective inhibition of gastrointestinal beta-glucuronidase by polyvinylbenzyl D-glucaro(1,4)lactonate: attachment of D-glucaro(1,4)lactone to polyvinylbenzyl chloride. | 1993 | Hum Exp Toxicol | pmid:8096720 |
Marselos M et al. | Aldehyde dehydrogenase inducibility and ethanol preference in rats. | 1975 | Med. Biol. | pmid:810629 |
Marselos M and Laitinen M | Starvation and phenobarbital treatment effects on drug hydroxylation and glucuronidation in the rat liver and small intestinal mucosa. | 1975 | Biochem. Pharmacol. | pmid:811226 |
Franco G and Fonte R | Advances in evaluating liver response to operating theatre work: urinary D-glucaric acid as an index of effect. | 1994 | Occup Med (Lond) | pmid:8167312 |
Ferreira M et al. | Determinants of urinary thioethers, D-glucaric acid and mutagenicity after exposure to polycyclic aromatic hydrocarbons assessed by air monitoring and measurement of 1-hydroxypyrene in urine: a cross-sectional study in workers of coke and graphite-electrode-producing plants. | 1994 | Int Arch Occup Environ Health | pmid:8175189 |
Newman MA et al. | Urinary biological monitoring markers of anticancer drug exposure in oncology nurses. | 1994 | Am J Public Health | pmid:8179062 |
Webb TE et al. | Pharmacokinetics relevant to the anti-carcinogenic and anti-tumor activities of glucarate and the synergistic combination of glucarate:retinoid in the rat. | 1994 | Biochem. Pharmacol. | pmid:8185680 |
Curley RW et al. | Activity of D-glucarate analogues: synergistic antiproliferative effects with retinoid in cultured human mammary tumor cells appear to specifically require the D-glucarate structure. | 1994 | Life Sci. | pmid:8190001 |
Marselos M | Genetic variation of drug-metabolizing enzymes in the wistar rat. | 1976 | Acta Pharmacol Toxicol (Copenh) | pmid:821309 |
Hoffmann D | [Role of phagocytosis and soluble antibacterial factors in experimental immunization of Locusta migratoria]. | 1976 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:821627 |
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Webb TE et al. | Mechanism of growth inhibition of mammary carcinomas by glucarate and the glucarate: retinoid combination. | 1993 Nov-Dec | Anticancer Res. | pmid:8297119 |
Suzuki A et al. | Iatrogenic osteomalacia caused by intravenous administration of saccharated ferric oxide. | 1993 | Am. J. Hematol. | pmid:8317471 |
Yaoita H et al. | Distribution of deoxyglucose and technetium-99m-glucarate in the acutely ischemic myocardium. | 1993 | J. Nucl. Med. | pmid:8326389 |
Notten WR and Henderson PT | The interaction of chemical compounds with the functional state of the liver. II. Estimation of changes in D-glucaric acid synthesis as a method for diagnosing exposure to xenobiotics. | 1977 | Int Arch Occup Environ Health | pmid:832915 |
Poon R et al. | HPLC determination of D-glucaric acid in human urine. | 1993 May-Jun | J Anal Toxicol | pmid:8336488 |
Okuyama T et al. | [Measurement and its fluctuation of urinary glucaric acid in newborns]. | 1993 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:8340644 |
Höchli P et al. | Repeated continuous administration of low doses of intravenous iron in anemic patients with active rheumatoid arthritis. | 1993 | Eur. J. Haematol. | pmid:8348948 |
Sandstad O et al. | Urinary D-glucaric acid, a marker substance for microsomal enzyme induction. Methodological aspects, responses to alcohol and findings in workers exposed to toluene. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8378735 |
Ballinger JR et al. | Effect of hypoxia on the accumulation of technetium-99m-glucarate and technetium-99m-gluconate by Chinese hamster ovary cells in vitro. | 1993 | J. Nucl. Med. | pmid:8381475 |