Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ho YC et al. | Human hepatic beta-glucuronidase: an enzyme kinetic study. | 1985 | Enzyme | pmid:3987656 |
Ohnhaus EE et al. | Liver blood flow and enzyme induction in man. | 1985 | Hepatogastroenterology | pmid:4007764 |
Idéo G et al. | Urinary D-glucaric acid excretion in the Seveso area, polluted by tetrachloro-dibenzo-p-dioxin (TCDD): five years of experience. | 1985 | Environ. Health Perspect. | pmid:4029098 |
Couvaris M et al. | Bioavailability of hetacillin in rats after liver enzyme induction by various inducers with or without protein binding properties. | 1985 Jan-Mar | Eur J Drug Metab Pharmacokinet | pmid:4029217 |
Kinoshita H et al. | The relationship between hepatic microsomal biphenyl 2-hydroxylase, 4-hydroxylase and urinary glucaric acid excretion in the rat. | 1985 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:4085526 |
Pitt D and Mosley MJ | Enzymes of gluconate metabolism and glycolysis in Penicillium notatum. | 1985 | Antonie Van Leeuwenhoek | pmid:4091540 |
Steinberg KK et al. | Assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure using a modified D-glucaric acid assay. | 1985 | J Toxicol Environ Health | pmid:4093993 |
Hunter J et al. | Urinary D-glucaric-acid excretion as a test for hepatic enzyme induction in man. | 1971 | Lancet | pmid:4100904 |
Aarts EM | D-glucaric-acid excretion as a test for hepatic enzyme induction. | 1971 | Lancet | pmid:4102545 |
Hunter J et al. | D-glucaric-acid excretion as a test for hepatic enzyme induction. | 1971 | Lancet | pmid:4103690 |
Edwards OM et al. | Changes in cortisol metabolism following rifampicin therapy. | 1974 | Lancet | pmid:4140269 |
Sotaniemi EA et al. | Glucaric acid as an indicator of use of enzyme-inducing drugs. | 1974 | Clin. Pharmacol. Ther. | pmid:4150733 |
Latham AN | D-Glucaric acid as an index of hepatic enzyme induction by anticonvulsant drugs in man. | 1974 | J. Pharm. Pharmacol. | pmid:4151390 |
Smith SE and Rawlins MD | Prediction of drug oxidation rates in man: lack of correlation with serum gamma-glutamyl transpeptidase and urinary excretion of D-glucaric acid and 6 beta-hydroxycortisol. | 1974 | Eur. J. Clin. Pharmacol. | pmid:4153008 |
Davidson DC et al. | Assessment of plasma glutamyl transpeptidase activity and urinary D-glucaric acid excretion as indices of enzyme induction. | 1974 | Clin Sci Mol Med | pmid:4154014 |
Smirne S et al. | [Serum gamma-glutamyl-transpeptidase and urinary excretion of D-glucaric acid in epileptic patients treated with anticonvulsants]. | 1974 Jul-Aug | Riv Neurol | pmid:4155805 |
Ohnhaus EE et al. | The effect of enzyme induction on diazepam metabolism in man. | 1979 | Br J Clin Pharmacol | pmid:42427 |
Freundt KJ | Production of endogenous D-glucaric acid and oxidative N-demethylation of amidopyrine in man: lack of correlation. | 1979 | Int J Clin Pharmacol Biopharm | pmid:429081 |
Park BK et al. | [Modification of the action of drugs by inhibition of their metabolism]. | 1979 | Recenti Prog Med | pmid:42953 |
Notten WR and Henderson PT | Effect of disulfiram on the urinary D-glucaric acid excretion and activity of some enzymes involved in drug metabolism in guinea-pig. | 1973 | Arch Int Pharmacodyn Ther | pmid:4357069 |
March J et al. | Values for urinary excretion of D-glucaric acid by normal individuals. | 1974 | Clin. Chem. | pmid:4416840 |
Cunningham JL and Evans DA | Urinary D-glucaric acid excretion and acetanilide pharmacokinetics before and during diphenylhydantoin administration. | 1974 | Eur. J. Clin. Pharmacol. | pmid:4417891 |
Hunter J et al. | Changes in D-glucaric acid excretion in relationship to alterations in the rate of antipyrine metabolism in man. | 1974 | Biochem. Pharmacol. | pmid:4429583 |
Perucca E et al. | The comparative enzyme-inducing properties of antiepileptic drugs [proceedings]. | 1979 | Br J Clin Pharmacol | pmid:444364 |
Furuno K et al. | Effect of D-glucaric acid derivatives on stability of rat liver lysosomes and erythrocytes. | 1974 | Jpn. J. Pharmacol. | pmid:4463271 |
Hinohara Y et al. | Glucuronic acid pathway in alloxan diabetic rabbits. (I). Urinary excretion of metabolites related to the glucuronic acid pathway. | 1974 | Jpn. J. Pharmacol. | pmid:4463273 |
Del Ninno E et al. | [The d-glucaric acid test in the evaluation of the inductive properties of phenobarbital and spironalactone]. | 1974 | Acta Vitaminol. Enzymol. | pmid:4480343 |
Bergonzi P et al. | [Long-term anticonvulsant therapy and calcium and phosphorus metabolism]. | 1979 Jan-Feb | Riv Neurol | pmid:451400 |
Masaki H | [Metabolic pathway of D-glucaric acid synthesis from D-glucuronolactone in the skin. II. Identification of the intermediates in D-glucuronolactone D-glucaric acid metabolism]. | 1972 | Nihon Hifuka Gakkai Zasshi | pmid:4540858 |
Nasaki H | [Metabolic pathway of D-glucaric acid synthesis from D-glucuronolactone in the skin. 1. D-glucaric acid and D-glucuronolactone dehydrogenase activities in the human skin--feedback mechanism of beta-glucuronidase]. | 1972 | Nihon Hifuka Gakkai Zasshi | pmid:4540880 |
Hunter J et al. | Urinary D-glucaric acid excretion and total liver content of cytochrome P-450 in guinea-pigs: relationship during enzyme induction and following inhibition of protein synthesis. | 1973 | Biochem. Pharmacol. | pmid:4693495 |
Sartor P and Cohere G | [Iron saccharate capture by rat uterus epithelium. Experimental study with respect to hormonal status]. | 1973 | C. R. Seances Soc. Biol. Fil. | pmid:4794498 |
Cassimos C et al. | Urinary D-glucaric acid excretion in normal and G-6-PD-deficient children with favism. | 1974 | J. Pediatr. | pmid:4826626 |
Simmons CJ et al. | Urinary D-glucaric acid assay by an improved enzymatic procedure. | 1974 | Clin. Chim. Acta | pmid:4856673 |
Makki KA et al. | Overnight urine specimens for the determination of D-glucaric acid excretion in man. | 1979 | Br J Clin Pharmacol | pmid:486295 |
Maxwell JD et al. | Folate deficiency after anticonvulsant drugs: an effect of hepatic enzyme induction? | 1972 | Br Med J | pmid:5008482 |
Matsui M et al. | Studies on the glucaric acid pathway in the metabolism of D-glucuronic acid in mammals. IV. Fluorometric method for the determination of D-glucaric acid in serum. | 1972 | Chem. Pharm. Bull. | pmid:5065229 |
Buchanan N et al. | Antipyrine pharmacokinetics and D-glucaric excretion in kwashiorkor. | 1979 | Am. J. Clin. Nutr. | pmid:506967 |
von Stockhausen HB and Struve M | Investigation of accelerated metabolic function in small for gestational age infants. | 1979 | Eur. J. Pediatr. | pmid:510320 |
Masuda H and Heirwegh KP | Different inhibition rates of beta-glucuronidase fractions in human gallbladder bile by glucaro-1, 4-lactone. | 1979 | Fukuoka Igaku Zasshi | pmid:511089 |
Hunter J et al. | Altered calcium metabolism in epileptic children on anticonvulsants. | 1971 | Br Med J | pmid:5115570 |
Kennedy AC et al. | Hypercalcaemia in rheumatoid arthritis: investigation of its causes and implications. | 1979 | Ann. Rheum. Dis. | pmid:518139 |
Henry DA et al. | The [14C]-aminopyrine breath test. A comparison of different forms of analysis. | 1979 | Br J Clin Pharmacol | pmid:533576 |
Reeves DS et al. | Pharmacokinetics of tetroxoprim and sulphadiazine in human volunteers. | 1979 | J. Antimicrob. Chemother. | pmid:536337 |
Wade A et al. | Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl. | 1979 | Biochem. J. | pmid:540044 |
Street JC and Chadwick RW | Ascorbic acid requirements and metabolism in relation to organochlorine pesticides. | 1975 | Ann. N. Y. Acad. Sci. | pmid:54013 |
Hunter J et al. | Urinary d-glucaric acid excretion as a measure of hepatic enzyme induction in man. | 1971 | Clin Sci | pmid:5550888 |
Glaser JH and Conrad HE | Chondroitin SO4 catabolism in chick embryo chondrocytes. | 1979 | J. Biol. Chem. | pmid:570972 |
Váradi A | 3-Trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332). Liver enzyme induction and D-glucaric acid excretion. | 1978 | Arzneimittelforschung | pmid:581947 |
Gachályi B et al. | Effect of alphamethyldopa on the half-lives of antipyrine, tolbutamide and D-glucaric acid excretion in man. | 1980 | Int J Clin Pharmacol Ther Toxicol | pmid:6103880 |