Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hu Q et al. | Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. | 2010 | Lab. Invest. | pmid:20065947 |
Simpson JA et al. | Letter 2: Randomized clinical trial of preoperative intravenous iron sucrose to reduce blood transfusion in anaemic patients after colorectal cancer surgery (Br J Surg 2009; 96: 1122-1128). | 2010 | Br J Surg | pmid:20069594 |
Ranganathan P and Pramesh CS | Letter 1: Randomized clinical trial of preoperative intravenous iron sucrose to reduce blood transfusion in anaemic patients after colorectal cancer surgery (Br J Surg 2009; 96: 1122-1128). | 2010 | Br J Surg | pmid:20069595 |
Chaudhuri RR et al. | Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. | 2010 | PLoS ONE | pmid:20098708 |
Kowalczyk MC et al. | Synergistic effects of combined phytochemicals and skin cancer prevention in SENCAR mice. | 2010 | Cancer Prev Res (Phila) | pmid:20103723 |
Moon TS et al. | Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli. | 2010 | Metab. Eng. | pmid:20117231 |
Li LO et al. | Early hepatic insulin resistance in mice: a metabolomics analysis. | 2010 | Mol. Endocrinol. | pmid:20150186 |
Gredilla E et al. | [Treating severe acute anemia due to vaginal bleeding in the Jehovah's Witness: a report of 2 cases]. | 2009 | Rev Esp Anestesiol Reanim | pmid:20151526 |
pmid:20162193 | ||||
PERSOONIAL Reflections. | 2009 | Persoonia | pmid:20198167 | |
Bologa M et al. | Pregnancy-induced changes in drug metabolism in epileptic women. | 1991 | J. Pharmacol. Exp. Ther. | pmid:2033516 |
Wu CJ et al. | Comparison of parenteral iron sucrose and ferric chloride during erythropoietin therapy of haemodialysis patients. | 2010 | Nephrology (Carlton) | pmid:20377770 |
Lajolo C et al. | Calcium glucarate inhibits DMBA-induced oral carcinogenesis in the hamster: histomorphometric evaluation. | 2010 | Anticancer Res. | pmid:20393005 |
Rangel EB et al. | Labile plasma iron generation after intravenous iron is time-dependent and transitory in patients undergoing chronic hemodialysis. | 2010 | Ther Apher Dial | pmid:20438541 |
Tampi R | Delayed adverse reactions to iron polymaltose and iron sucrose. | 2010 | Intern Med J | pmid:20446963 |
Rombouts K and Marra F | Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis. | 2010 | Dig Dis | pmid:20460917 |
pmid:20466657 | ||||
Garcia-Fernandez N et al. | Randomized clinical trial on acute effects of i.v. iron sucrose during haemodialysis. | 2010 | Nephrology (Carlton) | pmid:20470276 |
Beck IA | Serendipity lost: a digressive account of an experience in the investigation of glucoronic acid metabolism in diabetes mellitus. | 1991 | R I Med J | pmid:2047701 |
Firoz BF et al. | Eosinophilic fasciitis secondary to intravenous iron infusions. | 2010 | Dermatol. Online J. | pmid:20492822 |
Johnson AC et al. | Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20504881 |
Fernández-Gallego J et al. | [Treatment with intravenous iron and ferritin level]. | 2010 | Nefrologia | pmid:20514109 |
Ciuffi M et al. | Lipid peroxidation induced "in vivo" by iron-carbohydrate complex in the rat brain cortex. | 1991 | Neurochem. Res. | pmid:2052138 |
Hoffman K et al. | Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age. | 2010 | Environ. Health Perspect. | pmid:20551004 |
Suzuki E et al. | Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics. | 2010 | Drug Metab. Dispos. | pmid:20551238 |
Gupta A et al. | Response to iron sucrose in dialysis patients sensitive to iron dextran. | 2010 | Saudi J Kidney Dis Transpl | pmid:20587886 |
Chinnappa S and Bhandari S | Influence of intravenous iron therapy on novel markers of iron deficiency. | 2010 | Int J Artif Organs | pmid:20593351 |
Birgegård G et al. | High incidence of iron depletion and restless leg syndrome (RLS) in regular blood donors: intravenous iron sucrose substitution more effective than oral iron. | 2010 | Vox Sang. | pmid:20598107 |
Malovrh M et al. | The influence of need-based, continuous, low-dose iron replacement on hemoglobin levels in hemodialysis patients treated with erythropoiesis-stimulating agents. | 2011 | Artif Organs | pmid:20618233 |
Serrano-Trenas JA et al. | Role of perioperative intravenous iron therapy in elderly hip fracture patients: a single-center randomized controlled trial. | 2011 | Transfusion | pmid:20630042 |
Zhang ZW et al. | The plastid hexokinase pHXK: a node of convergence for sugar and plastid signals in Arabidopsis. | 2010 | FEBS Lett. | pmid:20650273 |
Okada DR et al. | 99mTc-glucarate kinetics differentiate normal, stunned, hibernating, and nonviable myocardium in a perfused rat heart model. | 2010 | Eur. J. Nucl. Med. Mol. Imaging | pmid:20652807 |
Sturm B et al. | In vitro study on the effects of iron sucrose, ferric gluconate and iron dextran on redox-active iron and oxidative stress. | 2010 | Arzneimittelforschung | pmid:20712137 |
pmid:20716362 | ||||
Swarnalatha G et al. | Oxidative stress in hemodialysis patients receiving intravenous iron therapy and the role of N-acetylcysteine in preventing oxidative stress. | 2010 | Saudi J Kidney Dis Transpl | pmid:20814119 |
Rodionov DA et al. | Genomic encyclopedia of sugar utilization pathways in the Shewanella genus. | 2010 | BMC Genomics | pmid:20836887 |
Do PT et al. | The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population. | 2010 | Plant Physiol. | pmid:20841452 |
Filisetti P et al. | [D-glucaric acid. A new method proposed to investigate damage from exposure to anesthetic gas and vapors]. | 1990 | Minerva Anestesiol | pmid:2084591 |
Froessler B and Papendorf D | Intravenous iron sucrose--an effective and attractive modality for perioperative anaemia management. | 2010 | Anaesth Intensive Care | pmid:20865896 |
Saluk-Juszczak J | A comparative study of antioxidative activity of calcium-D-glucarate, sodium-D-gluconate and D-glucono-1,4-lactone in a human blood platelet model. | 2010 | Platelets | pmid:20873960 |
Agarwal R et al. | Proteinuria induced by parenteral iron in chronic kidney disease--a comparative randomized controlled trial. | 2011 | Clin J Am Soc Nephrol | pmid:20876669 |
pmid:20951177 | ||||
Kell DB | Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. | 2010 | Arch. Toxicol. | pmid:20967426 |
Lawrence MC et al. | Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF-{alpha} gene expression in pancreatic islet endocrine cells. | 2011 | J. Biol. Chem. | pmid:21059644 |
Kolodziejczyk J et al. | In vitro study of the antioxidative properties of the glucose derivatives against oxidation of plasma components. | 2011 | J. Physiol. Biochem. | pmid:21086198 |
Bager P and Dahlerup JF | The health care cost of intravenous iron treatment in IBD patients depends on the economic evaluation perspective. | 2010 | J Crohns Colitis | pmid:21122539 |
Krafft A and Breymann C | Iron sucrose with and without recombinant erythropoietin for the treatment of severe postpartum anemia: a prospective, randomized, open-label study. | 2011 | J. Obstet. Gynaecol. Res. | pmid:21159035 |
Lippow SM et al. | Engineering enzyme specificity using computational design of a defined-sequence library. | 2010 | Chem. Biol. | pmid:21168766 |
Yoon J et al. | Postoperative high-dose intravenous iron sucrose with low dose erythropoietin therapy after total hip replacement. | 2010 | Korean J. Intern. Med. | pmid:21179286 |
Stefánsson BV et al. | Acute oxidative stress following intravenous iron injection in patients on chronic hemodialysis: a comparison of iron-sucrose and iron-dextran. | 2011 | Nephron Clin Pract | pmid:21196770 |
Pai AB et al. | Non-transferrin bound iron, cytokine activation and intracellular reactive oxygen species generation in hemodialysis patients receiving intravenous iron dextran or iron sucrose. | 2011 | Biometals | pmid:21229380 |
Laidlaw M et al. | Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial. | 2010 | Breast Cancer (Auckl) | pmid:21234288 |
Vanderford NL | The role of MafA in regulating cytokine expression in pancreatic beta cells. | 2011 | J. Biol. Chem. | pmid:21239506 |
Centeno DC et al. | Malate plays a crucial role in starch metabolism, ripening, and soluble solid content of tomato fruit and affects postharvest softening. | 2011 | Plant Cell | pmid:21239646 |
pmid:21256833 | ||||
Ibert M et al. | Evidence of benzilic rearrangement during the electrochemical oxidation of D-glucose to D-glucaric acid. | 2011 | Carbohydr. Res. | pmid:21269605 |
Fenwick S and Peebles G | Total dose infusion of intravenous iron in patients with chronic kidney disease receiving haemodialysis. | 2011 | J Ren Care | pmid:21288317 |
Toyokuni S | Mysterious link between iron overload and CDKN2A/2B. | 2011 | J Clin Biochem Nutr | pmid:21297911 |
Auerbach M | Should intravenous iron be upfront therapy for iron deficiency anemia? | 2011 | Pediatr Blood Cancer | pmid:21298731 |
Crary SE et al. | Intravenous iron sucrose for children with iron deficiency failing to respond to oral iron therapy. | 2011 | Pediatr Blood Cancer | pmid:21298748 |
pmid:21304025 | ||||
Gambini JP et al. | Evaluation of 99mTc-glucarate as a breast cancer imaging agent in a xenograft animal model. | 2011 | Nucl. Med. Biol. | pmid:21315281 |
pmid:21322558 | ||||
Walther J et al. | Hot transcriptomics. | 2011 | Archaea | pmid:21350598 |
Rottembourg J et al. | Do two intravenous iron sucrose preparations have the same efficacy? | 2011 | Nephrol. Dial. Transplant. | pmid:21355067 |
Steele VE et al. | Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents. | 1990 | Cancer Res. | pmid:2138505 |
Yetman AT and Everitt MD | The role of iron deficiency in protein-losing enteropathy following the Fontan procedure. | 2011 Jul-Aug | Congenit Heart Dis | pmid:21392262 |
Solak Y et al. | Comparison of adverse-event profiles of intravenous low-molecular-weight iron dextran and iron sucrose in peritoneal dialysis patients. | 2011 | Ren Fail | pmid:21401355 |
Meier T et al. | Physicochemical and toxicological characterization of a new generic iron sucrose preparation. | 2011 | Arzneimittelforschung | pmid:21428246 |
pmid:21479479 | ||||
Takeda Y et al. | Effect of intravenous saccharated ferric oxide on serum FGF23 and mineral metabolism in hemodialysis patients. | 2011 | Am. J. Nephrol. | pmid:21502756 |
Ruiz JC et al. | Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strains. | 2011 | PLoS ONE | pmid:21533164 |
Bhattacharya S et al. | Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. | 2011 Nov-Dec | J. Biochem. Mol. Toxicol. | pmid:21538728 |
Atalay H et al. | Safety profiles of total dose infusion of low-molecular-weight iron dextran and high-dose iron sucrose in renal patients. | 2011 | Hemodial Int | pmid:21564503 |
pmid:21632954 | ||||
pmid:21633980 | ||||
pmid:21645582 | ||||
pmid:21684753 | ||||
Vu'o'ng Lê B et al. | New rat models of iron sucrose-induced iron overload. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21685238 |
Kowalczyk MC et al. | Modulation of biomarkers related to tumor initiation and promotion in mouse skin by a natural β-glucuronidase inhibitor and its precursors. | 2011 | Oncol. Rep. | pmid:21687956 |
Evstatiev R et al. | FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. | 2011 | Gastroenterology | pmid:21699794 |
pmid:21705493 | ||||
Bailie GR et al. | Differences in spontaneously reported hypersensitivity and serious adverse events for intravenous iron preparations: comparison of Europe and North America. | 2011 | Arzneimittelforschung | pmid:21755809 |
Gomollón F and Gisbert JP | IBD: Intravenous iron in IBD--what's the best preparation? | 2011 | Nat Rev Gastroenterol Hepatol | pmid:21788975 |
Lv YK et al. | Poly[dimethyl-ammonium [aquadi-μ(2)-oxalato-samarate(III)] trihydrate]. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21836843 |
Lv YK et al. | Poly[dimethyl-ammonium [aquadi-μ(2)-oxalato-yttriate(III)] trihydrate]. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21836844 |
Bisbe E et al. | A multicentre comparative study on the efficacy of intravenous ferric carboxymaltose and iron sucrose for correcting preoperative anaemia in patients undergoing major elective surgery. | 2011 | Br J Anaesth | pmid:21841061 |
Blumenthal HJ et al. | Specific enzymatic assay for D-glucarate in human serum. | 1990 | Anal. Biochem. | pmid:2187374 |
Goggin MM et al. | Analysis of total and transferrin-bound iron in human serum for pharmacokinetic studies of iron-sucrose formulations. | 2011 | Bioanalysis | pmid:21877893 |
Toblli JE et al. | Assessment of the extent of oxidative stress induced by intravenous ferumoxytol, ferric carboxymaltose, iron sucrose and iron dextran in a nonclinical model. | 2011 | Arzneimittelforschung | pmid:21899208 |
Kowalczyk M et al. | Ferumoxytol: a new era of iron deficiency anemia treatment for patients with chronic kidney disease. | 2011 Nov-Dec | J. Nephrol. | pmid:21956770 |
pmid:21962070 | ||||
Bhattacharya S et al. | D-saccharic acid-1,4-lactone ameliorates alloxan-induced diabetes mellitus and oxidative stress in rats through inhibiting pancreatic β-cells from apoptosis via mitochondrial dependent pathway. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21982801 |
Di Nocera PP et al. | Genome organization of epidemic Acinetobacter baumannii strains. | 2011 | BMC Microbiol. | pmid:21985032 |
Denton TT et al. | Characterization of D-glucaric acid using NMR, X-ray crystal structure, and MM3 molecular modeling analyses. | 2011 | Carbohydr. Res. | pmid:22015400 |
Ozkurt S et al. | Acute and subacute effects of EV iron sucrose on endothelial functions in hemodialysis patients. | 2012 | Ren Fail | pmid:22017464 |
Monsénégo J et al. | Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis. | 2012 | J. Hepatol. | pmid:22037024 |
pmid:22037665 | ||||
Lê BV et al. | Modulation of Pseudomonas aeruginosa lipopolysaccharide-induced lung inflammation by chronic iron overload in rat. | 2012 | FEMS Immunol. Med. Microbiol. | pmid:22066700 |
Walaszek Z | Potential use of D-glucaric acid derivatives in cancer prevention. | 1990 | Cancer Lett. | pmid:2208084 |