Glucaric acid
Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Glucaric acid?
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Glucaric acid
PubChem Associated disorders and diseases
What pathways are associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Glucaric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Glucaric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Glucaric acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with Glucaric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Glucaric acid?
Knock-out
Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Glucaric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Okam MM et al. | Comparative rates of adverse events with different formulations of intravenous iron. | 2012 | Am. J. Hematol. | pmid:22965928 |
| Derman R et al. | A randomized trial of iron isomaltoside versus iron sucrose in patients with iron deficiency anemia. | 2017 | Am. J. Hematol. | pmid:28052413 |
| Suzuki A et al. | Iatrogenic osteomalacia caused by intravenous administration of saccharated ferric oxide. | 1993 | Am. J. Hematol. | pmid:8317471 |
| Hetzel D et al. | A Phase III, randomized, open-label trial of ferumoxytol compared with iron sucrose for the treatment of iron deficiency anemia in patients with a history of unsatisfactory oral iron therapy. | 2014 | Am. J. Hematol. | pmid:24639149 |
| Macdougall IC and Roche A | Administration of intravenous iron sucrose as a 2-minute push to CKD patients: a prospective evaluation of 2,297 injections. | 2005 | Am. J. Kidney Dis. | pmid:16112047 |
| Chandler G et al. | Intravenous iron sucrose: establishing a safe dose. | 2001 | Am. J. Kidney Dis. | pmid:11684551 |
| Zager RA et al. | Parenteral iron formulations: a comparative toxicologic analysis and mechanisms of cell injury. | 2002 | Am. J. Kidney Dis. | pmid:12087566 |
| Oldham FB | Continuity of research outcomes: the correlation of bench toxicity mechanisms to clinical outcomes--are they dependable? | 2002 | Am. J. Kidney Dis. | pmid:12407662 |
| St Peter WL et al. | Trends in intravenous iron use among dialysis patients in the United States (1994-2002). | 2005 | Am. J. Kidney Dis. | pmid:16183420 |
| Folkert VW et al. | Chronic use of sodium ferric gluconate complex in hemodialysis patients: safety of higher-dose (> or =250 mg) administration. | 2003 | Am. J. Kidney Dis. | pmid:12612989 |
| Yee J and Besarab A | Iron sucrose: the oldest iron therapy becomes new. | 2002 | Am. J. Kidney Dis. | pmid:12460028 |
| Bailie GR et al. | Parenteral iron use in the management of anemia in end-stage renal disease patients. | 2000 | Am. J. Kidney Dis. | pmid:10620537 |
| Van Wyck DB et al. | Safety and efficacy of iron sucrose in patients sensitive to iron dextran: North American clinical trial. | 2000 | Am. J. Kidney Dis. | pmid:10873877 |
| Fishbane S | Safety issues with iron sucrose. | 2003 | Am. J. Kidney Dis. | pmid:12666081 |
| Geisser P | Reactivity of iron compounds. | 2003 | Am. J. Kidney Dis. | pmid:14582056 |
| Danielson BG and Beshara S | Pharmacokinetics and utilization of iron sucrose. | 2003 | Am. J. Kidney Dis. | pmid:14582057 |
| McMahon LP et al. | Effects of different dialysis membranes on serum concentrations of epoetin alfa, darbepoetin alfa, enoxaparin, and iron sucrose during dialysis. | 2004 | Am. J. Kidney Dis. | pmid:15332224 |
| Goldstein SL et al. | Comparison of the safety and efficacy of 3 iron sucrose iron maintenance regimens in children, adolescents, and young adults with CKD: a randomized controlled trial. | 2013 | Am. J. Kidney Dis. | pmid:23245582 |
| Silverberg DS et al. | Intravenous iron supplementation for the treatment of the anemia of moderate to severe chronic renal failure patients not receiving dialysis. | 1996 | Am. J. Kidney Dis. | pmid:8659499 |
| Charytan C et al. | Efficacy and safety of iron sucrose for iron deficiency in patients with dialysis-associated anemia: North American clinical trial. | 2001 | Am. J. Kidney Dis. | pmid:11157370 |
| Duffy CI | Iron sucrose or ferric gluconate? | 2001 | Am. J. Kidney Dis. | pmid:11728988 |
| Freburger JK et al. | Changing patterns of anemia management in US hemodialysis patients. | 2012 | Am. J. Med. | pmid:22938926 |
| Rostoker G et al. | Hemodialysis-associated hemosiderosis in the era of erythropoiesis-stimulating agents: a MRI study. | 2012 | Am. J. Med. | pmid:22998881 |
| Barton Pai A et al. | Non-transferrin-bound iron is associated with enhanced Staphylococcus aureus growth in hemodialysis patients receiving intravenous iron sucrose. | 2006 | Am. J. Nephrol. | pmid:16809897 |
| Kamanna VS et al. | Iron sucrose promotes endothelial injury and dysfunction and monocyte adhesion/infiltration. | 2012 | Am. J. Nephrol. | pmid:22212390 |
| Ichii H et al. | Iron sucrose impairs phagocytic function and promotes apoptosis in polymorphonuclear leukocytes. | 2012 | Am. J. Nephrol. | pmid:22722756 |
| Takeda Y et al. | Effect of intravenous saccharated ferric oxide on serum FGF23 and mineral metabolism in hemodialysis patients. | 2011 | Am. J. Nephrol. | pmid:21502756 |
| Taccone-Gallucci M et al. | Risk of iron overload and 'hemochromatosis allele(s)' in patients on maintenance hemodialysis. | 1987 | Am. J. Nephrol. | pmid:3578371 |
| Malindretos P et al. | Slow intravenous iron administration does not aggravate oxidative stress and inflammatory biomarkers during hemodialysis: a comparative study between iron sucrose and iron dextran. | 2007 | Am. J. Nephrol. | pmid:17804904 |
| Breymann C et al. | Efficacy and safety of intravenously administered iron sucrose with and without adjuvant recombinant human erythropoietin for the treatment of resistant iron-deficiency anemia during pregnancy. | 2001 | Am. J. Obstet. Gynecol. | pmid:11262469 |
| Bayoumeu F et al. | Iron therapy in iron deficiency anemia in pregnancy: intravenous route versus oral route. | 2002 | Am. J. Obstet. Gynecol. | pmid:11904617 |
| Douard V et al. | Excessive fructose intake causes 1,25-(OH)(2)D(3)-dependent inhibition of intestinal and renal calcium transport in growing rats. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23571713 |
| Bitsi S et al. | Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes. | 2016 | Am. J. Physiol. Endocrinol. Metab. | pmid:26670484 |
| Stachowska-Pietka J et al. | Computer simulations of osmotic ultrafiltration and small-solute transport in peritoneal dialysis: a spatially distributed approach. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22301624 |
| Johnson AC et al. | Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20504881 |
| Agarwal R | On the nature of proteinuria with acute renal injury in patients with chronic kidney disease. | 2005 | Am. J. Physiol. Renal Physiol. | pmid:15467003 |
| Froessler B and Papendorf D | Intravenous iron sucrose--an effective and attractive modality for perioperative anaemia management. | 2010 | Anaesth Intensive Care | pmid:20865896 |
| Marsh CA | An enzymatic determination of D-glucaric acid by conversion to pyruvate. | 1985 | Anal. Biochem. | pmid:3893213 |
| Previs SF et al. | Use of [6,6-2H2]glucose and of low-enrichment [U-13C6]-glucose for sequential or simultaneous measurements of glucose turnover by gas chromatography-mass spectrometry. | 1994 | Anal. Biochem. | pmid:8053553 |
| Blumenthal HJ et al. | Specific enzymatic assay for D-glucarate in human serum. | 1990 | Anal. Biochem. | pmid:2187374 |
| Ryzewski CN and Malejka-Giganti D | A novel assay of glucuronidation of C- and N-hydroxylated metabolites of the carcinogen N-2-fluorenylacetamide. | 1983 | Anal. Biochem. | pmid:6408946 |
| Nakajima M et al. | A solid-phase substrate of heparanase: its application to assay of human melanoma for heparan sulfate degradative activity. | 1986 | Anal. Biochem. | pmid:3766958 |
| Cuenca J et al. | Efficacy of intravenous iron sucrose administration for correcting preoperative anemia in patients scheduled for major orthopedic surgery. | 2008 | Anesthesiology | pmid:18580186 |
| Bayoumeu F et al. | [Antipublic antibodies and pregnancy: use of iron sucrose in autologous blood donation with cryopreservation]. | 2002 | Ann Fr Anesth Reanim | pmid:11878118 |
| Dolara P et al. | Variations of some parameters of enzyme induction in chemical workers. | 1982 | Ann Occup Hyg | pmid:6124202 |
| Dolara P et al. | Enzyme induction in humans exposed to styrene. | 1983 | Ann Occup Hyg | pmid:6614729 |
| Siest G et al. | [Biological tests as indirect indicators of the activity of drug metabolizing enzymes. Use of glucaric acid and gamma-glutamyltransferase]. | 1977 | Ann. Biol. Clin. (Paris) | pmid:28055 |
| Brewster MA | Biomarkers of xenobiotic exposures. | 1988 Jul-Aug | Ann. Clin. Lab. Sci. | pmid:3044268 |
| Street JC and Chadwick RW | Ascorbic acid requirements and metabolism in relation to organochlorine pesticides. | 1975 | Ann. N. Y. Acad. Sci. | pmid:54013 |
| Addyman R et al. | Urinary glucaric acid excretion in rheumatoid arthritis: influence of disease activity and disease modifying drugs. | 1996 | Ann. Rheum. Dis. | pmid:8774168 |
| van Soesbergen RM et al. | Bone metabolism in rheumatoid arthritis compared with postmenopausal osteoporosis. | 1986 | Ann. Rheum. Dis. | pmid:3947143 |
| Kennedy AC et al. | Hypercalcaemia in rheumatoid arthritis: investigation of its causes and implications. | 1979 | Ann. Rheum. Dis. | pmid:518139 |
| Glassman E | Oral iron therapy with ferrous fumarate and polysaccharide iron complex. | 1992 | ANNA J | pmid:1627011 |
| Kuramitsu Y et al. | A new anti-metastatic drug, ND-2001, inhibits lung metastases in rat hepatoma cells by suppressing haptotaxis of tumor cells toward laminin. | 1998 | Anticancer Drugs | pmid:9491797 |
| Nakatsugawa S et al. | Inhibitory effect of ND2001 on spontaneous multiple metastasis of NC 65 tumors derived from human renal cancer cells intradermally transplanted into nude mice. | 1999 | Anticancer Drugs | pmid:10211554 |
| Kuramitsu Y et al. | ND-2001 suppresses lung metastasis of human renal cancer cells in athymic mice. | 1998 | Anticancer Drugs | pmid:9823433 |
| Webb TE et al. | Mechanism of growth inhibition of mammary carcinomas by glucarate and the glucarate: retinoid combination. | 1993 Nov-Dec | Anticancer Res. | pmid:8297119 |
| Abou-Issa H et al. | Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. | 1995 May-Jun | Anticancer Res. | pmid:7645962 |
| Abou-Issa H et al. | Basis for the anti-tumor and chemopreventive activities of glucarate and the glucarate:retinoid combination. | 1993 Mar-Apr | Anticancer Res. | pmid:8517653 |
| Lajolo C et al. | Calcium glucarate inhibits DMBA-induced oral carcinogenesis in the hamster: histomorphometric evaluation. | 2010 | Anticancer Res. | pmid:20393005 |
| Pitt D and Mosley MJ | Enzymes of gluconate metabolism and glycolysis in Penicillium notatum. | 1985 | Antonie Van Leeuwenhoek | pmid:4091540 |
| Lubberink M et al. | Quantification aspects of patient studies with 52Fe in positron emission tomography. | 1999 | Appl Radiat Isot | pmid:10581681 |
| Yang Z et al. | Symbiosis between microorganisms from kombucha and kefir: Potential significance to the enhancement of kombucha function. | 2010 | Appl. Biochem. Biotechnol. | pmid:18810658 |
| Moon TS et al. | Production of glucaric acid from a synthetic pathway in recombinant Escherichia coli. | 2009 | Appl. Environ. Microbiol. | pmid:19060162 |
| Alsasua A et al. | [Urinary D-glucaric acid in portocaval shunt rats (author's transl)]. | 1980 | Arch Farmacol Toxicol | pmid:7387201 |
| Notten WR and Henderson PT | Effect of disulfiram on the urinary D-glucaric acid excretion and activity of some enzymes involved in drug metabolism in guinea-pig. | 1973 | Arch Int Pharmacodyn Ther | pmid:4357069 |
| Cuenca J et al. | Role of parenteral iron in the management of anaemia in the elderly patient undergoing displaced subcapital hip fracture repair: preliminary data. | 2005 | Arch Orthop Trauma Surg | pmid:15789233 |
| Picaud JC et al. | [Iron supplementation in preterm infants treated with erythropoietin]. | 1999 | Arch Pediatr | pmid:10394459 |
| Keith DA et al. | Microsomal enzyme induction and gingival enlargement in subjects taking phenytoin. | 1981 | Arch. Oral Biol. | pmid:6951516 |
| Miguel JC et al. | Effects of iron salts in sucrose on dental caries and plaque in rats. | 1997 | Arch. Oral Biol. | pmid:9233847 |
| Kell DB | Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. | 2010 | Arch. Toxicol. | pmid:20967426 |
| de Wolff FA et al. | The effects of valproic acid on liver function. | 1983 | Arch. Toxicol. Suppl. | pmid:6138013 |
| Tesseromatis C et al. | Influence of liver enzyme induction caused by diphenylhydantoin and diazepam on bone mass of rats. | 1980 | Arch. Toxicol. Suppl. | pmid:6933970 |
| Walther J et al. | Hot transcriptomics. | 2011 | Archaea | pmid:21350598 |
| Malovrh M et al. | The influence of need-based, continuous, low-dose iron replacement on hemoglobin levels in hemodialysis patients treated with erythropoiesis-stimulating agents. | 2011 | Artif Organs | pmid:20618233 |
| Toblli JE et al. | Evaluation of toxicity and oxidative stress induced by intravenous iron isomaltoside 1000 in a nonclinical model. | 2011 | Arzneimittelforschung | pmid:22164963 |
| Sturm B et al. | In vitro study on the effects of iron sucrose, ferric gluconate and iron dextran on redox-active iron and oxidative stress. | 2010 | Arzneimittelforschung | pmid:20712137 |
| Meier T et al. | Physicochemical and toxicological characterization of a new generic iron sucrose preparation. | 2011 | Arzneimittelforschung | pmid:21428246 |
| Toblli JE et al. | Differences between original intravenous iron sucrose and iron sucrose similar preparations. | 2009 | Arzneimittelforschung | pmid:19517894 |
| Bailie GR et al. | Differences in spontaneously reported hypersensitivity and serious adverse events for intravenous iron preparations: comparison of Europe and North America. | 2011 | Arzneimittelforschung | pmid:21755809 |
| Toblli JE et al. | Assessment of the extent of oxidative stress induced by intravenous ferumoxytol, ferric carboxymaltose, iron sucrose and iron dextran in a nonclinical model. | 2011 | Arzneimittelforschung | pmid:21899208 |
| Váradi A | 3-Trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332). Liver enzyme induction and D-glucaric acid excretion. | 1978 | Arzneimittelforschung | pmid:581947 |
| Goggin MM et al. | Analysis of total and transferrin-bound iron in human serum for pharmacokinetic studies of iron-sucrose formulations. | 2011 | Bioanalysis | pmid:21877893 |
| Abou-Issa H et al. | Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2783140 |
| Wade A et al. | Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl. | 1979 | Biochem. J. | pmid:540044 |
| Nakamura T et al. | A novel oligosaccharide, GlcA beta 1-4Xyl beta 1-(4-methylumbelliferone), synthesized by human cultured skin fibroblasts. | 1994 | Biochem. J. | pmid:7818474 |
| LEVVY GA | The inhibition of beta-glucuronidase by derivatives of saccharic acid. | 1952 | Biochem. J. | pmid:14915974 |
| Dwivedi C et al. | Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. | 1990 | Biochem. Med. Metab. Biol. | pmid:2346674 |
| Marselos M et al. | Evidence that D-glucaro-1,4-lactone shortens the pharmacological action of drugs being disposed via the bile as glucuronides. | 1975 | Biochem. Pharmacol. | pmid:1191334 |
| Hunter J et al. | Changes in D-glucaric acid excretion in relationship to alterations in the rate of antipyrine metabolism in man. | 1974 | Biochem. Pharmacol. | pmid:4429583 |
| Ciuffi M et al. | Effect of 21-aminosteroid U74500A (pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(5,6-bis(diethylamino)-2-pyridinyl)-1-piperazinyl)-16-methyl-, HCl (16 alpha)) on rat brain cortex lipid peroxidation induced "in vivo" by iron-carbohydrate. | 1994 | Biochem. Pharmacol. | pmid:8031311 |
| Bhatnagar R et al. | Growth suppression of human breast carcinoma cells in culture by N-(4-hydroxyphenyl)retinamide and its glucuronide and through synergism with glucarate. | 1991 | Biochem. Pharmacol. | pmid:1826840 |
| Hunter J et al. | Urinary D-glucaric acid excretion and total liver content of cytochrome P-450 in guinea-pigs: relationship during enzyme induction and following inhibition of protein synthesis. | 1973 | Biochem. Pharmacol. | pmid:4693495 |
| Hoyle VR et al. | Studies on the biochemical effects of the aldose reductase inhibitor 2,7-difluorospirofluorene-9,5'-imidazolidine-2',4'-dione (Al 1576, HOE 843). Detection of D-glucaric and D-glucuronic acid excretion by high resolution 1H and 13C NMR spectroscopy. | 1992 | Biochem. Pharmacol. | pmid:1642638 |
| Marselos M and Laitinen M | Starvation and phenobarbital treatment effects on drug hydroxylation and glucuronidation in the rat liver and small intestinal mucosa. | 1975 | Biochem. Pharmacol. | pmid:811226 |
| Webb TE et al. | Pharmacokinetics relevant to the anti-carcinogenic and anti-tumor activities of glucarate and the synergistic combination of glucarate:retinoid in the rat. | 1994 | Biochem. Pharmacol. | pmid:8185680 |
| Brunelle FM and Verbeeck RK | Glucuronidation of diflunisal by rat liver microsomes. Effect of microsomal beta-glucuronidase activity. | 1993 | Biochem. Pharmacol. | pmid:8267644 |
| Sandle LN et al. | Indirect evidence for hepatic induction in patients with cholesterol gallstones. | 1997 | Biochem. Soc. Trans. | pmid:9388642 |
| Yew WS et al. | Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2. | 2007 | Biochemistry | pmid:17649980 |
| Tian B et al. | Predicting enzyme-substrate specificity with QM/MM methods: a case study of the stereospecificity of (D)-glucarate dehydratase. | 2013 | Biochemistry | pmid:23901785 |