Glucaric acid

Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glucaric acid?

Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glucaric acid

MeSH term MeSH ID Detail
Parkinson Disease D010300 53 associated lipids
von Willebrand Diseases D014842 2 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Atherosclerosis D050197 85 associated lipids
Insulin Resistance D007333 99 associated lipids
Dehydration D003681 11 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Critical Illness D016638 13 associated lipids
Anemia, Iron-Deficiency D018798 6 associated lipids
Myocardial Stunning D017682 10 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Carcinogenesis D063646 3 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Restless Legs Syndrome D012148 2 associated lipids
Iron Overload D019190 11 associated lipids
Anemia, Refractory D000753 3 associated lipids
Calcium Metabolism Disorders D002128 1 associated lipids
Anemia, Neonatal D000751 1 associated lipids
Gilbert Disease D005878 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Glucaric acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Glucaric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Glucaric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Glucaric acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with Glucaric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glucaric acid?

Knock-out

Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Glucaric acid

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Authors Title Published Journal PubMed Link
Freche JP et al. [Variation in the urinary excretion of 6-beta-hydroxycortisol in humans after administration of the new isoquinoline derivative, PK-11195 (52028 RP)]. 1989 Sep-Oct Therapie pmid:2573163
pmid:25698609
Toblli JE et al. Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron. 2015 Heart Lung Circ pmid:25666998
Frezza M et al. Abnormal serum gamma-glutamyltranspeptidase in alcoholics. Clues to its explanation. 1989 Neth J Med pmid:2563572
Franco G Occupational exposure to anaesthetics: liver injury, microsomal enzyme induction and preventive aspects. 1989 G Ital Med Lav pmid:2562737
pmid:25609135
Almilaji A et al. Regulation of the voltage gated K channel Kv1.3 by recombinant human klotho protein. 2014 Kidney Blood Press. Res. pmid:25571875
pmid:25514745
pmid:25514744
Tiwari P et al. Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events. 2015 Chem. Biol. Interact. pmid:25478867
Raman S et al. Evolution-guided optimization of biosynthetic pathways. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25453111
pmid:25381611
pmid:25326244
pmid:25315985
Abou-Issa H et al. Chemotherapeutic evaluation of glucarate and N-(4-hydroxyphenyl)retinamide alone and in combination in the rat mammary tumor model. 1989 J. Natl. Cancer Inst. pmid:2531231
Shiue E et al. Improving product yields on D-glucose in Escherichia coli via knockout of pgi and zwf and feeding of supplemental carbon sources. 2015 Biotechnol. Bioeng. pmid:25258165
Beguin Y and Jaspers A Iron sucrose - characteristics, efficacy and regulatory aspects of an established treatment of iron deficiency and iron-deficiency anemia in a broad range of therapeutic areas. 2014 Expert Opin Pharmacother pmid:25186219
Corwin HL and Napolitano LM Anemia in the critically ill: do we need to live with it?*. 2014 Crit. Care Med. pmid:25126804
pmid:25123238
Dwivedi C et al. Modulation of chemically initiated and promoted skin tumorigenesis in CD-1 mice by dietary glucarate. 1989 May-Jun J. Environ. Pathol. Toxicol. Oncol. pmid:2509679
Price E et al. A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL. 2014 Blood Cells Mol. Dis. pmid:25065855
pmid:25050519
pmid:25036548
pmid:24972288
Ferioli A et al. Alteration of steroid hormone sulfation and D-glucaric acid excretion in lead workers. 1989 Jul-Sep Biol Trace Elem Res pmid:2484601
pmid:24816781
Pieracci FM et al. A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness*. 2014 Crit. Care Med. pmid:24797376
Florey L The uptake of particulate matter by endothelial cells. 1967 Proc. R. Soc. Lond., B, Biol. Sci. pmid:24796034
Tiwari P and Gupta KP Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents. 2014 Toxicol. Appl. Pharmacol. pmid:24792773
Oredipe OA et al. Chemopreventative activity of dietary glucarate on azoxymethane-induced altered hepatic foci in rats. 1989 Res. Commun. Chem. Pathol. Pharmacol. pmid:2479062
pmid:24765889
pmid:24725852
Kuo KL et al. Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD. 2014 J. Am. Soc. Nephrol. pmid:24722448
Wagner G and Hollmann S Uronic acid dehydrogenase from Pseudomonas syringae. Purification and properties. 1976 Eur. J. Biochem. pmid:2471
Hetzel D et al. A Phase III, randomized, open-label trial of ferumoxytol compared with iron sucrose for the treatment of iron deficiency anemia in patients with a history of unsatisfactory oral iron therapy. 2014 Am. J. Hematol. pmid:24639149
pmid:24611780
pmid:24588937
pmid:24566860
pmid:24535226
Macdougall IC et al. A randomized comparison of ferumoxytol and iron sucrose for treating iron deficiency anemia in patients with CKD. 2014 Clin J Am Soc Nephrol pmid:24458078
Shah RB et al. Pharmaceutical characterization and thermodynamic stability assessment of a colloidal iron drug product: iron sucrose. 2014 Int J Pharm pmid:24440404
Perelló MF et al. Intravenous ferrous sucrose versus placebo in addition to oral iron therapy for the treatment of severe postpartum anaemia: a randomised controlled trial. 2014 BJOG pmid:24423186
Balling A et al. [Chronic hemorrhagic iron deficiency. Sources of hemorrhage, blood loss and systematic iron substitution]. 1987 Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. pmid:2440780
Italia K et al. Hydroxyurea could be a good clinically relevant iron chelator. 2013 PLoS ONE pmid:24349400
Soufras GD et al. Fatal anaphylactic reaction to iron sucrose in pregnancy: iron-induced Kounis syndrome? 2013 Nov-Dec Indian J Pharmacol pmid:24347784
pmid:24333274
Sasaki Y et al. Hepcidin production in response to iron is controlled by monocyte-derived humoral factors. 2014 Int. J. Hematol. pmid:24293278
Toyokuni S Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis. 2014 Redox Rep. pmid:24257681
pmid:24219061
Lu QY et al. Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase. 2014 J Pharm Biomed Anal pmid:24176739
Ferumoxytol: an intravenous iron, riskier than iron sucrose. 2013 Prescrire Int pmid:24171212
Guzelian PS Clinical evaluation of liver structure and function in humans exposed to halogenated hydrocarbons. 1985 Environ. Health Perspect. pmid:2411535
Athibovonsuk P et al. Prevention of blood transfusion with intravenous iron in gynecologic cancer patients receiving platinum-based chemotherapy. 2013 Gynecol. Oncol. pmid:24099839
pmid:24087940
pmid:24081613
Michigami T [Updates on rickets and osteomalacia: FGF23-mediated hypophosphatemic rickets/osteomalacia]. 2013 Clin Calcium pmid:24076640
Palmer K et al. Review of available intravenous iron preparations in hemodialysis. 2013 Apr-Jun CANNT J pmid:24069699
Kriplani A et al. Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy. 2013 Indian J. Med. Res. pmid:24056559
Kalaivani K Use of intravenous iron sucrose for treatment of anaemia in pregnancy. 2013 Indian J. Med. Res. pmid:24056552
Abdel-Razeq H et al. Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study. 2013 Drug Des Devel Ther pmid:24039403
Rowlands M et al. The effect of intravenous iron on postoperative transfusion requirements in hip fracture patients: study protocol for a randomized controlled trial. 2013 Trials pmid:24015990
Vadasz D et al. Intravenous iron sucrose for restless legs syndrome in pregnant women with low serum ferritin. 2013 Sleep Med. pmid:24012019
Grim K et al. Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose. 2013 Sleep Med. pmid:23993871
Onken JE et al. Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial. 2014 Nephrol. Dial. Transplant. pmid:23963731
Roots I et al. Comparison of methods to study enzyme induction in man. 1975 Adv. Exp. Med. Biol. pmid:239546
Beck-da-Silva L et al. Iron therapy in patients with heart failure. A straight shot. 2013 Int. J. Cardiol. pmid:23931974
Latham AN Effect of in vitro changes in urinary pH on the enzymatic measurement and daily variation in excretion of D-glucaric acid. 1975 J. Pharm. Pharmacol. pmid:239180
Giger M and Achermann R [Iron substitution in outpatients in Switzerland: Increase of costs associated with intravenous administration]. 2013 Z Evid Fortbild Qual Gesundhwes pmid:23916272
Tian B et al. Predicting enzyme-substrate specificity with QM/MM methods: a case study of the stereospecificity of (D)-glucarate dehydratase. 2013 Biochemistry pmid:23901785
pmid:23895304
Contreras C et al. Comparative study of the oral absorption of microencapsulated ferric saccharate and ferrous sulfate in humans. 2014 Eur J Nutr pmid:23892521
pmid:23890881
Beguin Y et al. Darbepoetin-alfa and intravenous iron administration after autologous hematopoietic stem cell transplantation: a prospective multicenter randomized trial. 2013 Am. J. Hematol. pmid:23873823
Galanopoulou P et al. Effect of enzyme induction on bioavailability of hetacillin in patients treated with anticonvulsants and chlorpromazine. 1990 Jan-Mar Eur J Drug Metab Pharmacokinet pmid:2384113
Kowalczyk MC et al. Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice. 2013 Int. J. Oncol. pmid:23835587
García Erce JA et al. [Thoughts about the usefulness of the preoperatory administration of intravenous iron in hip fracture surgery]. 2013 Med Clin (Barc) pmid:23790583
Potthoff SA and Münch HG [Safety aspects of parenteral iron supplementation therapies in patients with chronic kidney disease]. 2013 Dtsch. Med. Wochenschr. pmid:23737117
Wang Y et al. Hepatoprotective effects of kombucha tea: identification of functional strains and quantification of functional components. 2014 J. Sci. Food Agric. pmid:23716136
Janus N et al. Administration of intravenous iron complexes on implantable central venous access port in cancer patients in France: the FERPAC survey. 2013 Support Care Cancer pmid:23715817
Barot BS et al. Physicochemical and structural characterization of iron-sucrose formulations: a comparative study. 2014 Pharm Dev Technol pmid:23701359
pmid:23681275
Beck-da-Silva L et al. IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia. 2013 Int. J. Cardiol. pmid:23680589
Biggar P and Hahn KM [Importance of the different i.v. iron generations for everyday medical practice]. 2013 MMW Fortschr Med pmid:23678667
Elford P et al. Biodistribution and predictive hepatic gene expression of intravenous iron sucrose. 2013 Nov-Dec J Pharmacol Toxicol Methods pmid:23624021
Lynn S and McDaniel J Managing severe anemia when the patient is a Jehovah's Witness. 2013 JAAPA pmid:23610833
Bespalov VG and Aleksandrov VA [Anticarcinogenic effect of potassium salts of glucaric and glucuronic acid in induced models of cervical and esophageal tumors]. 2012 Vopr Onkol pmid:23607211
Munoz C et al. Klotho sensitivity of the hERG channel. 2013 FEBS Lett. pmid:23603386
Ho YD and Ho KJ Biliary D-glucaric acid: its quantitation and preventive role in gallstone formation. 1990 Scand. J. Gastroenterol. pmid:2359994
Douard V et al. Excessive fructose intake causes 1,25-(OH)(2)D(3)-dependent inhibition of intestinal and renal calcium transport in growing rats. 2013 Am. J. Physiol. Endocrinol. Metab. pmid:23571713
Mishra A et al. Fatal anaphylactic reaction to iron sucrose in pregnancy. 2013 Jan-Feb Indian J Pharmacol pmid:23543624
Yang Z et al. Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. 2013 Infect. Immun. pmid:23509143
Yamamoto S et al. Iatrogenic osteomalacia: report of two cases. 2013 J. UOEH pmid:23475021
Dwivedi C et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. 1990 Biochem. Med. Metab. Biol. pmid:2346674
Basora M et al. Optimizing preoperative haemoglobin with intravenous iron. 2013 Br J Anaesth pmid:23404979
pmid:23364652
Newman MA et al. Biological monitoring screening of patients provided antineoplastic drugs including adriamycin, cyclophosphamide, 5-fluorouracil, methotrexate, and vincristine. 1990 Cancer Res. pmid:2334930
Araki T et al. Clinical efficacy of two forms of intravenous iron--saccharated ferric oxide and cideferron--for iron deficiency anemia. 2012 Pharmazie pmid:23346769
Moore KL et al. Uncommon adverse effect of a common medication. 2013 Tidsskr. Nor. Laegeforen. pmid:23344600
pmid:23316876
Moorani KN and Asim S Parenteral iron sucrose in iron deficiency anaemia of paediatric chronic kidney disease. 2011 Jul-Sep J Ayub Med Coll Abbottabad pmid:23272434