Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Couvaris M et al. | Bioavailability of hetacillin in rats after liver enzyme induction by various inducers with or without protein binding properties. | 1985 Jan-Mar | Eur J Drug Metab Pharmacokinet | pmid:4029217 |
Kinoshita H et al. | The relationship between hepatic microsomal biphenyl 2-hydroxylase, 4-hydroxylase and urinary glucaric acid excretion in the rat. | 1985 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:4085526 |
Heinemeyer G et al. | D-glucaric acid excretion in critical care patients--comparison with 6 beta-hydroxycortisol excretion and serum gamma-glutamyltranspeptidase activity and relation to multiple drug therapy. | 1986 | Br J Clin Pharmacol | pmid:2868749 |
Lutz W and Kralkowska E | [Laboratory diagnosis of subclinical forms of chemically-induced liver damage]. | 1986 | Wiad. Lek. | pmid:2873689 |
Walaszek Z et al. | Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. | 1986 | Carcinogenesis | pmid:3091283 |
Nakajima M et al. | A solid-phase substrate of heparanase: its application to assay of human melanoma for heparan sulfate degradative activity. | 1986 | Anal. Biochem. | pmid:3766958 |
Walaszek Z et al. | Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis. | 1986 | Cancer Lett. | pmid:3768860 |
Marsh CA | Biosynthesis of D-glucaric acid in mammals: a free-radical mechanism? | 1986 | Carbohydr. Res. | pmid:3779687 |
Perry W and Jenkins MV | Note on the enzyme assay for urinary D-glucaric acid and correlation with rifampicin-induced mixed function oxidase activity. | 1986 | Int J Clin Pharmacol Ther Toxicol | pmid:3793294 |
Balázová E et al. | Antitumor activity of four polymer bound trans-1,2-diaminocyclohexaneplatinum(II)-4-carboxyphtalate complexes tested in different model systems. | 1986 | Neoplasma | pmid:3808121 |
Price DE et al. | The effect of low-dose phenobarbitone on three indices of hepatic microsomal enzyme induction. | 1986 | Br J Clin Pharmacol | pmid:3567022 |
Horváth T et al. | Disorders of biotransformation during the progression of alcoholic liver disease. | 1986 | Acta Med Hung | pmid:3601579 |
van Soesbergen RM et al. | Bone metabolism in rheumatoid arthritis compared with postmenopausal osteoporosis. | 1986 | Ann. Rheum. Dis. | pmid:3947143 |
George S et al. | The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen. | 1986 | Eur. J. Clin. Pharmacol. | pmid:3956563 |
Traeger A et al. | Beta-adrenoceptor blocking drugs and cytochrome P-450: the influence of propranolol treatment on caffeine, antipyrine, D-glucaric acid and indocyanine green elimination in patients with hepatic disorders. | 1986 | Int J Clin Pharmacol Res | pmid:3744626 |
MacNeil ML et al. | A semiautomated procedure for urinary D-glucaric acid using a centrifugal analyzer. | 1986 Jan-Feb | J Anal Toxicol | pmid:3951202 |
Kawahara K et al. | Urinary excretion of conjugates of dothiepin and northiaden (mono-N-demethyl-dothiepin) after an oral dose of dothiepin to humans. | 1986 Jan-Mar | Eur J Drug Metab Pharmacokinet | pmid:3720795 |
Steinberg KK and Needham LL | A comparison of two methods for quantifying D-glucaric acid. | 1986 Jul-Aug | J Anal Toxicol | pmid:3747452 |
Couvaris M et al. | Comparative study of the effects of some inducers with or without protein binding properties on bioavailability of isoxazolylpenicillins in rats. | 1986 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:3816874 |
Strack D et al. | Enzymic synthesis of caffeoylglucaric Acid from chlorogenic Acid and glucaric Acid by a protein preparation from tomato cotyledons. | 1987 | Plant Physiol. | pmid:16665274 |
Balling A et al. | [Chronic hemorrhagic iron deficiency. Sources of hemorrhage, blood loss and systematic iron substitution]. | 1987 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2440780 |
Tutor JC et al. | Urinary excretion of D-glucaric acid in porphyria cutanea tarda. | 1987 | J. Clin. Chem. Clin. Biochem. | pmid:2895161 |
Dwivedi C et al. | Net glucuronidation in different rat strains: importance of microsomal beta-glucuronidase. | 1987 | FASEB J. | pmid:3115856 |
Oredipe OA et al. | Effects of calcium glucarate on the promotion of diethylnitrosamine-initiated altered hepatic foci in rats. | 1987 | Cancer Lett. | pmid:3690519 |
Gachályi B et al. | Pharmacogenetic differences in the inhibitory effect of cimetidine on the metabolism of antipyrine. | 1987 | Eur. J. Clin. Pharmacol. | pmid:3830247 |
Kinouchi T et al. | In vitro intestinal microflora-mediated metabolism of biliary metabolites from 1-nitropyrene-treated rats. | 1987 | Microbiol. Immunol. | pmid:3451027 |
Sandle LN and Braganza JM | An evaluation of the low-pH enzymatic assay of urinary D-glucaric acid, and its use as a marker of enzyme induction in exocrine pancreatic disease. | 1987 | Clin. Chim. Acta | pmid:3568402 |
Taccone-Gallucci M et al. | Risk of iron overload and 'hemochromatosis allele(s)' in patients on maintenance hemodialysis. | 1987 | Am. J. Nephrol. | pmid:3578371 |
Oyabu H et al. | Nonbacterial transformation of bilirubin in bile. | 1987 | Dig. Dis. Sci. | pmid:3608728 |
Heinemeyer G et al. | Kinetics of hexobarbital and dipyrone in critical care patients receiving high-dose pentobarbital. | 1987 | Eur. J. Clin. Pharmacol. | pmid:3595700 |
Apostoli P et al. | [Behavior of urinary D-glucaric acid in occupational exposure to inorganic lead]. | 1987 Sep-Oct | Med Lav | pmid:3447026 |
Tutor JC et al. | Urinary D-glucaric acid and serum hepatic enzyme levels in chronic alcoholics. | 1988 | Clin. Biochem. | pmid:2898981 |
Abou-Issa HM et al. | Putative metabolites derived from dietary combinations of calcium glucarate and N-(4-hydroxyphenyl)retinamide act synergistically to inhibit the induction of rat mammary tumors by 7,12-dimethylbenz[a]anthracene. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2967969 |
Kolmodin-Hedman B | Enzyme induction: its relevance for internal exposure and health risks. | 1988 | Int Arch Occup Environ Health | pmid:3049388 |
Mocarelli P et al. | A new method for D-glucaric acid excretion measurement that is suitable for automated instruments. | 1988 | Clin. Chem. | pmid:3180424 |
Walaszek Z et al. | Repression by sustained-release beta-glucuronidase inhibitors of chemical carcinogen-mediated induction of a marker oncofetal protein in rodents. | 1988 | J Toxicol Environ Health | pmid:3336058 |
Brewster MA | Biomarkers of xenobiotic exposures. | 1988 Jul-Aug | Ann. Clin. Lab. Sci. | pmid:3044268 |
Volpi R et al. | [Increased urinary excretion of D-glucaric acid in workers exposed to styrene in reinforced plastics industry]. | 1988 Mar-Apr | Med Lav | pmid:3173231 |
Dwivedi C et al. | Effect of dietary calcium glucarate on 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in CD-1 mice. | 1988 Nov-Dec | Cleve Clin J Med | pmid:3147822 |
Pasquini R et al. | Thioethers, mutagens, and D-glucaric acid in urine of operating room personnel exposed to anesthetics. | 1989 | Teratog., Carcinog. Mutagen. | pmid:2576815 |
Abou-Issa H et al. | Chemotherapeutic evaluation of glucarate and N-(4-hydroxyphenyl)retinamide alone and in combination in the rat mammary tumor model. | 1989 | J. Natl. Cancer Inst. | pmid:2531231 |
Mori M et al. | Urinary and biliary metabolites of mephentermine in male Wistar rats. | 1989 | Xenobiotica | pmid:2665325 |
Kitasato I et al. | Effect of glucarolactam on low-dose nephrotoxicities of dibekacin and gentamicin in Fischer rats. | 1989 | Drugs Exp Clin Res | pmid:2591297 |
Yokota M et al. | Effect of glucarolactam on ototoxicity of aminoglycoside antibiotics in guinea-pigs. | 1989 | Drugs Exp Clin Res | pmid:2591298 |
Horváth T et al. | Drug metabolism in drug-induced liver diseases: pathogenetic role of active metabolites. | 1989 | Acta Physiol Hung | pmid:2596319 |
Franco G | Occupational exposure to anaesthetics: liver injury, microsomal enzyme induction and preventive aspects. | 1989 | G Ital Med Lav | pmid:2562737 |
Frezza M et al. | Abnormal serum gamma-glutamyltranspeptidase in alcoholics. Clues to its explanation. | 1989 | Neth J Med | pmid:2563572 |
Oredipe OA et al. | Chemopreventative activity of dietary glucarate on azoxymethane-induced altered hepatic foci in rats. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2479062 |
Gourley GR et al. | The effect of saccharolactone on rat intestinal absorption of bilirubin in the presence of human breast milk. | 1989 | Pediatr. Res. | pmid:2704588 |
Pasquini R et al. | Urinary excretion of mutagens, thioethers and D-glucaric acid in workers exposed to bitumen fumes. | 1989 | Int Arch Occup Environ Health | pmid:2707871 |
Liddil JD et al. | Association of lysosomal activity with sensitivity and resistance to tumor necrosis factor in murine L929 cells. | 1989 | Cancer Res. | pmid:2713856 |
Dwivedi C et al. | Effects of the experimental chemopreventative agent, glucarate, on intestinal carcinogenesis in rats. | 1989 | Carcinogenesis | pmid:2752528 |
Okada S et al. | Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats. | 1989 | Br. J. Cancer | pmid:2803947 |
Macfadyen A and Ho KJ | D-glucaro-1,4-lactone: its excretion in the bile and urine and effect on the biliary secretion of beta-glucuronidase after oral administration in rats. | 1989 | Hepatology | pmid:2925160 |
Adzharov D et al. | [Effects of preliminary fasting on the development of D-galactosamine-induced acute lesion of the liver in rats]. | 1989 | Biull Eksp Biol Med | pmid:2914170 |
Abou-Issa H et al. | Synergistic interaction between 13-cis-retinoic acid and glucarate: activity against rat mammary tumor induction and MCF-7 cells. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2783140 |
Ferioli A et al. | Alteration of steroid hormone sulfation and D-glucaric acid excretion in lead workers. | 1989 Jul-Sep | Biol Trace Elem Res | pmid:2484601 |
Dwivedi C et al. | Modulation of chemically initiated and promoted skin tumorigenesis in CD-1 mice by dietary glucarate. | 1989 May-Jun | J. Environ. Pathol. Toxicol. Oncol. | pmid:2509679 |
Coddington KA et al. | Enterohepatic circulation of T-2 toxin metabolites in the rat. | 1989 Nov-Dec | Drug Metab. Dispos. | pmid:2575494 |
Freche JP et al. | [Variation in the urinary excretion of 6-beta-hydroxycortisol in humans after administration of the new isoquinoline derivative, PK-11195 (52028 RP)]. | 1989 Sep-Oct | Therapie | pmid:2573163 |
Walaszek Z | Potential use of D-glucaric acid derivatives in cancer prevention. | 1990 | Cancer Lett. | pmid:2208084 |
Blumenthal HJ et al. | Specific enzymatic assay for D-glucarate in human serum. | 1990 | Anal. Biochem. | pmid:2187374 |
Filisetti P et al. | [D-glucaric acid. A new method proposed to investigate damage from exposure to anesthetic gas and vapors]. | 1990 | Minerva Anestesiol | pmid:2084591 |
Pasquini R et al. | Urine mutagenicity and biochemical parameters as markers of exposure to petroleum pitch using a rat model. | 1990 | Environ. Mol. Mutagen. | pmid:2298199 |
Dwivedi C et al. | Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. | 1990 | Biochem. Med. Metab. Biol. | pmid:2346674 |
Ho YD and Ho KJ | Biliary D-glucaric acid: its quantitation and preventive role in gallstone formation. | 1990 | Scand. J. Gastroenterol. | pmid:2359994 |
Newman MA et al. | Biological monitoring screening of patients provided antineoplastic drugs including adriamycin, cyclophosphamide, 5-fluorouracil, methotrexate, and vincristine. | 1990 | Cancer Res. | pmid:2334930 |
Moretto A and Lotti M | Exposure to toluene increases the urinary excretion of D-glucaric acid. | 1990 | Br J Ind Med | pmid:2310708 |
Walaszek Z et al. | Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland. | 1990 | Cancer Lett. | pmid:2302696 |
Steele VE et al. | Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents. | 1990 | Cancer Res. | pmid:2138505 |
Galanopoulou P et al. | Effect of enzyme induction on bioavailability of hetacillin in patients treated with anticonvulsants and chlorpromazine. | 1990 Jan-Mar | Eur J Drug Metab Pharmacokinet | pmid:2384113 |
Beck IA | Serendipity lost: a digressive account of an experience in the investigation of glucoronic acid metabolism in diabetes mellitus. | 1991 | R I Med J | pmid:2047701 |
Ciuffi M et al. | Lipid peroxidation induced "in vivo" by iron-carbohydrate complex in the rat brain cortex. | 1991 | Neurochem. Res. | pmid:2052138 |
Yaoita H et al. | Localization of technetium-99m-glucarate in zones of acute cerebral injury. | 1991 | J. Nucl. Med. | pmid:1704054 |
Willerson JT | Detection of acute myocardial infarcts by infarct-avid imaging. | 1991 | J. Nucl. Med. | pmid:1846912 |
Bhatnagar R et al. | Growth suppression of human breast carcinoma cells in culture by N-(4-hydroxyphenyl)retinamide and its glucuronide and through synergism with glucarate. | 1991 | Biochem. Pharmacol. | pmid:1826840 |
Ball LM et al. | Formation of mutagenic urinary metabolites from 1-nitropyrene in germ-free and conventional rats: role of the gut flora. | 1991 | Carcinogenesis | pmid:1988167 |
Orlandi C et al. | Early scintigraphic detection of experimental myocardial infarction in dogs with technetium-99m-glucaric acid. | 1991 | J. Nucl. Med. | pmid:1992031 |
Bologa M et al. | Pregnancy-induced changes in drug metabolism in epileptic women. | 1991 | J. Pharmacol. Exp. Ther. | pmid:2033516 |
Franco G et al. | Behaviour of urinary D-glucaric acid excretion in surgical patients and anaesthesiology staff acutely exposed to isoflurane and nitrous oxide. | 1991 Nov-Dec | Med Lav | pmid:1803214 |
Pistelli A et al. | [Contribution of glutathione to detoxification in alcoholism. Biochemical-clinical studies]. | 1992 | Clin Ter | pmid:1358498 |
Mustajoki P et al. | Rapid normalization of antipyrine oxidation by heme in variegate porphyria. | 1992 | Clin. Pharmacol. Ther. | pmid:1544288 |
Wada S et al. | [Study of preventive effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU) or combination of HCFU and 2.5-di-O-acetyl-D-glucaro (1-4) (6-3) dilactone (SLA) after preservative operation against bladder cancer]. | 1992 | Hinyokika Kiyo | pmid:1546564 |
Kanamaru R and Wakui A | [Pharmacokinetic studies on fluorinated pyrimidine in cancer cell and tissue]. | 1992 | Gan To Kagaku Ryoho | pmid:1558391 |
Schmittgen TD et al. | Effects of 5-fluorouracil, leucovorin, and glucarate in rat colon-tumor explants. | 1992 | Cancer Chemother. Pharmacol. | pmid:1586977 |
Glassman E | Oral iron therapy with ferrous fumarate and polysaccharide iron complex. | 1992 | ANNA J | pmid:1627011 |
Hoyle VR et al. | Studies on the biochemical effects of the aldose reductase inhibitor 2,7-difluorospirofluorene-9,5'-imidazolidine-2',4'-dione (Al 1576, HOE 843). Detection of D-glucaric and D-glucuronic acid excretion by high resolution 1H and 13C NMR spectroscopy. | 1992 | Biochem. Pharmacol. | pmid:1642638 |
Koller WC et al. | Metabolism of glucurolactone to glucarate in Parkinson's disease. | 1992 | Neurology | pmid:1513472 |
Abou-Issa H et al. | Antitumour synergism between non-toxic dietary combinations of isotretinoin and glucarate. | 1992 | Eur. J. Cancer | pmid:1388036 |
Ohtani H et al. | Comparison of technetium-99m-glucarate and thallium-201 for the identification of acute myocardial infarction in rats. | 1992 | J. Nucl. Med. | pmid:1432160 |
Oredipe OA et al. | Dietary glucarate-mediated inhibition of initiation of diethylnitrosamine-induced hepatocarcinogenesis. | 1992 | Toxicology | pmid:1519243 |
Pak KY et al. | Labeling and stability of radiolabeled antibody fragments by a direct 99mTc-labeling method. | 1992 | Int J Rad Appl Instrum B | pmid:1522021 |
Pietrantonio AM et al. | [Urinary measurement of D-glucaric acid in operating room personnel in the Modena USL 16 hospitals]. | 1992 Jan-Nov | G Ital Med Lav | pmid:1345728 |
Hanaue H et al. | Estimation of the functional reserve of the human liver by urinary D-glucaric acid excretion after vitamin C administration. | 1993 | Tokai J. Exp. Clin. Med. | pmid:7940601 |
Sacco C et al. | Selective inhibition of gastrointestinal beta-glucuronidase by polyvinylbenzyl D-glucaro(1,4)lactonate: attachment of D-glucaro(1,4)lactone to polyvinylbenzyl chloride. | 1993 | Hum Exp Toxicol | pmid:8096720 |
Suzuki A et al. | Iatrogenic osteomalacia caused by intravenous administration of saccharated ferric oxide. | 1993 | Am. J. Hematol. | pmid:8317471 |
Sandstad O et al. | Urinary D-glucaric acid, a marker substance for microsomal enzyme induction. Methodological aspects, responses to alcohol and findings in workers exposed to toluene. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8378735 |
Brunelle FM and Verbeeck RK | Glucuronidation of diflunisal by rat liver microsomes. Effect of microsomal beta-glucuronidase activity. | 1993 | Biochem. Pharmacol. | pmid:8267644 |
Yaoita H et al. | Distribution of deoxyglucose and technetium-99m-glucarate in the acutely ischemic myocardium. | 1993 | J. Nucl. Med. | pmid:8326389 |
Höchli P et al. | Repeated continuous administration of low doses of intravenous iron in anemic patients with active rheumatoid arthritis. | 1993 | Eur. J. Haematol. | pmid:8348948 |