| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcoholism | D000437 | 27 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Kidney Neoplasms | D007680 | 29 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Hyperplasia | D006965 | 34 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
Glucaric acid
Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Glucaric acid?
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Glucaric acid
PubChem Associated disorders and diseases
What pathways are associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Glucaric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Glucaric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Glucaric acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with Glucaric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Glucaric acid?
Knock-out
Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Glucaric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fujimoto T et al. | A new clinical prognostic predictor for patients with biliary atresia. | 1994 | J. Pediatr. Surg. | pmid:8078014 |
| Cassimos C et al. | Urinary D-glucaric acid excretion in children with dystonic reactions caused by antiemetic drugs. | 1975 | J. Pediatr. | pmid:1185409 |
| Cassimos C et al. | Urinary D-glucaric acid excretion in normal and G-6-PD-deficient children with favism. | 1974 | J. Pediatr. | pmid:4826626 |
| Meyer MP et al. | A comparison of oral and intravenous iron supplementation in preterm infants receiving recombinant erythropoietin. | 1996 | J. Pediatr. | pmid:8765624 |
| Gehret TC et al. | Convenient large-scale synthesis of D-glucaro-1,4:6,3-dilactone. | 2009 | J. Org. Chem. | pmid:19777999 |
| Kochhar PK et al. | Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: a randomized clinical trial. | 2013 | J. Obstet. Gynaecol. Res. | pmid:22925176 |
| Devasenapathy N et al. | Is intravenous iron sucrose the treatment of choice for pregnant anemic women? | 2013 | J. Obstet. Gynaecol. Res. | pmid:23167561 |
| Krafft A and Breymann C | Iron sucrose with and without recombinant erythropoietin for the treatment of severe postpartum anemia: a prospective, randomized, open-label study. | 2011 | J. Obstet. Gynaecol. Res. | pmid:21159035 |
| Mariani G et al. | Detection of acute myocardial infarction by 99mTc-labeled D-glucaric acid imaging in patients with acute chest pain. | 1999 | J. Nucl. Med. | pmid:10565778 |
| Okada DR et al. | Early detection of infarct in reperfused canine myocardium using 99mTc-glucarate. | 2004 | J. Nucl. Med. | pmid:15073263 |
| Yaoita H et al. | Localization of technetium-99m-glucarate in zones of acute cerebral injury. | 1991 | J. Nucl. Med. | pmid:1704054 |
| Willerson JT | Detection of acute myocardial infarcts by infarct-avid imaging. | 1991 | J. Nucl. Med. | pmid:1846912 |
| Ballinger JR et al. | Effect of hypoxia on the accumulation of technetium-99m-glucarate and technetium-99m-gluconate by Chinese hamster ovary cells in vitro. | 1993 | J. Nucl. Med. | pmid:8381475 |
| Orlandi C et al. | Early scintigraphic detection of experimental myocardial infarction in dogs with technetium-99m-glucaric acid. | 1991 | J. Nucl. Med. | pmid:1992031 |
| Liu Z et al. | High-resolution imaging with (99m)Tc-glucarate for assessing myocardial injury in rat heart models exposed to different durations of ischemia with reperfusion. | 2004 | J. Nucl. Med. | pmid:15235074 |
| Oberhaensli RD et al. | Different actions of deferoxamine and iron on Ga-67 abscess detection in rats. | 1984 | J. Nucl. Med. | pmid:6587029 |
| Ohtani H et al. | Comparison of technetium-99m-glucarate and thallium-201 for the identification of acute myocardial infarction in rats. | 1992 | J. Nucl. Med. | pmid:1432160 |
| Yaoita H et al. | Distribution of deoxyglucose and technetium-99m-glucarate in the acutely ischemic myocardium. | 1993 | J. Nucl. Med. | pmid:8326389 |
| Usmanov RI et al. | Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. | 2008 Mar-Apr | J. Nephrol. | pmid:18446719 |
| Kowalczyk M et al. | Ferumoxytol: a new era of iron deficiency anemia treatment for patients with chronic kidney disease. | 2011 Nov-Dec | J. Nephrol. | pmid:21956770 |
| Kumbasar A et al. | The effect of different doses and types of intravenous iron on oxidative stress and inflammation in hemodialysis patients. | 2012 Sep-Oct | J. Nephrol. | pmid:22307439 |
| Leijn E et al. | Intravenous iron supplementation in children on hemodialysis. | 2004 May-Jun | J. Nephrol. | pmid:15365964 |
| Abou-Issa H et al. | Chemotherapeutic evaluation of glucarate and N-(4-hydroxyphenyl)retinamide alone and in combination in the rat mammary tumor model. | 1989 | J. Natl. Cancer Inst. | pmid:2531231 |
| Froessler B et al. | Intravenous iron sucrose versus oral iron ferrous sulfate for antenatal and postpartum iron deficiency anemia: a randomized trial. | 2013 | J. Matern. Fetal. Neonatal. Med. | pmid:23130909 |
| Agarwal R | Ironing out the mystery of nephrotoxicity of parenteral iron. | 2005 | J. Lab. Clin. Med. | pmid:16025083 |
| Sanai T et al. | Effect of saccharated ferric oxide and iron dextran on the metabolism of phosphorus in rats. | 2005 | J. Lab. Clin. Med. | pmid:16025088 |
| Cazzola M | Recombinant human erythropoietin to assist autologous blood donation by patients with anemia. | 1997 | J. Lab. Clin. Med. | pmid:9358072 |
| Rycroft D and Daniel JW | The excretion of D-glucaric acid in the urine of human volunteers following the administration of disopyramide. | 1976 | J. Int. Med. Res. | pmid:1026531 |
| Monsénégo J et al. | Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis. | 2012 | J. Hepatol. | pmid:22037024 |
| Roberton AM et al. | Two genes affecting glucarate utilization in Escherichia coli K12. | 1980 | J. Gen. Microbiol. | pmid:6999115 |
| RICHTER GW | The cellular transformation of injected colloidal iron complexes into ferritin and hemosiderin in experimental animals; a study with the aid of electron microscopy. | 1959 | J. Exp. Med. | pmid:13620849 |
| ELLIS JT | Glomerular lesions and the nephrotic syndrome in rabbits given saccharated iron oxide intravenously; with special reference to the part played by intracapillary precipitates in the pathogenesis of the lesions. | 1956 | J. Exp. Med. | pmid:13278460 |
| Zanor MI et al. | Metabolic characterization of loci affecting sensory attributes in tomato allows an assessment of the influence of the levels of primary metabolites and volatile organic contents. | 2009 | J. Exp. Bot. | pmid:19346240 |
| Dwivedi C et al. | Modulation of chemically initiated and promoted skin tumorigenesis in CD-1 mice by dietary glucarate. | 1989 May-Jun | J. Environ. Pathol. Toxicol. Oncol. | pmid:2509679 |
| Singh J and Gupta KP | Induction of apoptosis by calcium D-glucarate in 7,12-dimethyl benz [a] anthracene-exposed mouse skin. | 2007 | J. Environ. Pathol. Toxicol. Oncol. | pmid:17725531 |
| da Silva Krause M et al. | Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets. | 2012 | J. Endocrinol. | pmid:22761278 |
| Gargan R et al. | A concise biotyping system for differentiating strains of Escherichia coli. | 1982 | J. Clin. Pathol. | pmid:6757274 |
| Tutor JC et al. | Urinary excretion of D-glucaric acid in porphyria cutanea tarda. | 1987 | J. Clin. Chem. Clin. Biochem. | pmid:2895161 |
| Walters DG et al. | Direct determination of D-[U-14C] glucaric acid in urine by ion-exchange high-performance liquid chromatography. | 1983 | J. Chromatogr. | pmid:6423654 |
| Laakso EI et al. | Determination of D-glucaric acid by high-performance liquid chromatography. | 1983 | J. Chromatogr. | pmid:6668320 |
| ComÃn-Colet J et al. | A pilot evaluation of the long-term effect of combined therapy with intravenous iron sucrose and erythropoietin in elderly patients with advanced chronic heart failure and cardio-renal anemia syndrome: influence on neurohormonal activation and clinical outcomes. | 2009 | J. Card. Fail. | pmid:19879457 |
| Beck-da-Silva L et al. | Rationale and design of the IRON-HF study: a randomized trial to assess the effects of iron supplementation in heart failure patients with anemia. | 2007 | J. Card. Fail. | pmid:17338998 |
| Sricholpech M et al. | Lysyl hydroxylase 3-mediated glucosylation in type I collagen: molecular loci and biological significance. | 2012 | J. Biol. Chem. | pmid:22573318 |
| Aghaie A et al. | New insights into the alternative D-glucarate degradation pathway. | 2008 | J. Biol. Chem. | pmid:18364348 |
| Lawrence MC et al. | Calcineurin/nuclear factor of activated T cells and MAPK signaling induce TNF-{alpha} gene expression in pancreatic islet endocrine cells. | 2011 | J. Biol. Chem. | pmid:21059644 |
| Watanabe S et al. | alpha-ketoglutaric semialdehyde dehydrogenase isozymes involved in metabolic pathways of D-glucarate, D-galactarate, and hydroxy-L-proline. Molecular and metabolic convergent evolution. | 2007 | J. Biol. Chem. | pmid:17202142 |
| Vanderford NL | The role of MafA in regulating cytokine expression in pancreatic beta cells. | 2011 | J. Biol. Chem. | pmid:21239506 |
| Nakajima M et al. | Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase. | 1984 | J. Biol. Chem. | pmid:6698965 |
| Glaser JH and Conrad HE | Chondroitin SO4 catabolism in chick embryo chondrocytes. | 1979 | J. Biol. Chem. | pmid:570972 |
| Bhattacharya S et al. | Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. | 2011 Nov-Dec | J. Biochem. Mol. Toxicol. | pmid:21538728 |
| Monterrubio R et al. | A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli. | 2000 | J. Bacteriol. | pmid:10762278 |
| Yoon SH et al. | Cloning and characterization of uronate dehydrogenases from two pseudomonads and Agrobacterium tumefaciens strain C58. | 2009 | J. Bacteriol. | pmid:19060141 |
| Spiegel K et al. | Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. | 2005 | J. Appl. Physiol. | pmid:16227462 |
| Tryfinopoulou P et al. | Diversity of Shewanella population in fish Sparus aurata harvested in the Aegean Sea. | 2007 | J. Appl. Microbiol. | pmid:17714405 |
| Reeves DS et al. | Pharmacokinetics of tetroxoprim and sulphadiazine in human volunteers. | 1979 | J. Antimicrob. Chemother. | pmid:536337 |
| Furuno K et al. | Preventive effect of D-glucarate against renal damage induced by kanamycin. | 1976 | J. Antibiot. | pmid:993134 |
| Furuno K et al. | Effect of D-Glucarates on basic antibiotic-induced renal damage in rats. | 1976 | J. Antibiot. | pmid:931801 |
| Kuo KL et al. | Intravenous iron exacerbates oxidative DNA damage in peripheral blood lymphocytes in chronic hemodialysis patients. | 2008 | J. Am. Soc. Nephrol. | pmid:18495964 |
| Scheiber-Mojdehkar B et al. | Non-transferrin-bound iron in the serum of hemodialysis patients who receive ferric saccharate: no correlation to peroxide generation. | 2004 | J. Am. Soc. Nephrol. | pmid:15153577 |
| Kuo KL et al. | Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD. | 2014 | J. Am. Soc. Nephrol. | pmid:24722448 |
| Bolger AP et al. | Intravenous iron alone for the treatment of anemia in patients with chronic heart failure. | 2006 | J. Am. Coll. Cardiol. | pmid:16979010 |
| Toblli JE et al. | Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. | 2007 | J. Am. Coll. Cardiol. | pmid:17950147 |
| Francis GS and Kanderian A | Anemia and heart failure a new pathway? | 2007 | J. Am. Coll. Cardiol. | pmid:17950148 |
| Liu Y et al. | New poly(d-glucaramidoamine)s induce DNA nanoparticle formation and efficient gene delivery into mammalian cells. | 2004 | J. Am. Chem. Soc. | pmid:15198572 |
| Liu Y and Reineke TM | Hydroxyl stereochemistry and amine number within poly(glycoamidoamine)s affect intracellular DNA delivery. | 2005 | J. Am. Chem. Soc. | pmid:15740138 |
| Durlofsky L and Fruncillo RJ | Impaired drug-metabolizing ability in the burned rat. | 1982 | J Trauma | pmid:7143502 |
| Walters KR et al. | Methamphetamine causes anorexia in Drosophila melanogaster, exhausting metabolic reserves and contributing to mortality. | 2012 | J Toxicol Sci | pmid:22863857 |
| Collinot JP et al. | Evaluation of urinary D-glucaric acid excretion in workers exposed to butyl glycol. | 1996 | J Toxicol Environ Health | pmid:8691506 |
| Walaszek Z et al. | Repression by sustained-release beta-glucuronidase inhibitors of chemical carcinogen-mediated induction of a marker oncofetal protein in rodents. | 1988 | J Toxicol Environ Health | pmid:3336058 |
| Steinberg KK et al. | Assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure using a modified D-glucaric acid assay. | 1985 | J Toxicol Environ Health | pmid:4093993 |
| Fenwick S and Peebles G | Total dose infusion of intravenous iron in patients with chronic kidney disease receiving haemodialysis. | 2011 | J Ren Care | pmid:21288317 |
| Elford P et al. | Biodistribution and predictive hepatic gene expression of intravenous iron sucrose. | 2013 Nov-Dec | J Pharmacol Toxicol Methods | pmid:23624021 |
| Lai AA and Levy RH | Pharmacokinetic description of drug interactions by enzyme induction: carbamazepine-clonazepam in monkeys. | 1979 | J Pharm Sci | pmid:108383 |
| Tutor-Crespo M et al. | Isoforms of serum gamma-glutamyltransferase in epileptic patients treated with enzyme-inducing anticonvulsant drugs. | 2004 | J Pharm Pharm Sci | pmid:15576017 |
| Lu QY et al. | Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase. | 2014 | J Pharm Biomed Anal | pmid:24176739 |
| Christoph P et al. | Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. iron sucrose. | 2012 | J Perinat Med | pmid:22945271 |
| Pfenniger A et al. | Safety and efficacy of high-dose intravenous iron carboxymaltose vs. iron sucrose for treatment of postpartum anemia. | 2012 | J Perinat Med | pmid:22752771 |
| Németh I et al. | Hyperbilirubinemia and urinary D-glucaric acid excretion in premature infants following antepartum dexamethasone treatment. | 1981 | J Perinat Med | pmid:6783743 |
| Breymann C et al. | Milk iron content in breast-feeding mothers after administration of intravenous iron sucrose complex. | 2007 | J Perinat Med | pmid:17302514 |
| Wali A et al. | Comparative study--efficacy, safety and compliance of intravenous iron sucrose and intramuscular iron sorbitol in iron deficiency anemia of pregnancy. | 2002 | J Pak Med Assoc | pmid:12532571 |
| Nasir A et al. | Management of iron deficiency anaemia in gynaecological patients at Jinnah Postgraduate Medical Centre, Karachi. | 2011 | J Pak Med Assoc | pmid:22356035 |
| Gambini JP et al. | Evaluation of patients with head and neck cancer by means of 99mTc-glucarate. | 2009 | J Nucl Med Technol | pmid:19949020 |
| Okada DR et al. | Myocardial kinetics of Tc-99m glucarate in low flow, hypoxia, and aglycemia. | 2003 Mar-Apr | J Nucl Cardiol | pmid:12673182 |
| Beanlands RS et al. | Differentiation of myocardial ischemia and necrosis by technetium 99m glucaric acid kinetics. | 1997 Jul-Aug | J Nucl Cardiol | pmid:9278873 |
| Khaw BA et al. | Avidity of technetium 99m glucarate for the necrotic myocardium: in vivo and in vitro assessment. | 1997 Jul-Aug | J Nucl Cardiol | pmid:9278874 |
| Johnson LL et al. | Technetium-99m glucarate uptake in a swine model of limited flow plus increased demand. | 2000 Nov-Dec | J Nucl Cardiol | pmid:11144474 |
| Auerbach M and Ballard H | Intravenous iron in oncology. | 2008 | J Natl Compr Canc Netw | pmid:18597712 |
| Laman CA et al. | Parenteral iron therapy: a single institution's experience over a 5-year period. | 2005 | J Natl Compr Canc Netw | pmid:16316614 |
| Wilson PD et al. | An analysis of the health service efficiency and patient experience with two different intravenous iron preparations in a UK anaemia clinic. | 2013 | J Med Econ | pmid:22989163 |
| Al-Saran KA and Sabry AA | Pregnancy in dialysis patients: a case series. | 2008 | J Med Case Rep | pmid:18205953 |
| Breymann C | Treatment of iron deficiency anaemia in pregnancy and postpartum with special focus on intravenous iron sucrose complex. | 2005 | J Med Assoc Thai | pmid:17718296 |
| Reinisch W et al. | State of the iron: how to diagnose and efficiently treat iron deficiency anemia in inflammatory bowel disease. | 2013 | J Crohns Colitis | pmid:22917870 |
| Bager P and Dahlerup JF | The health care cost of intravenous iron treatment in IBD patients depends on the economic evaluation perspective. | 2010 | J Crohns Colitis | pmid:21122539 |
| Tutor-Crespo MJ et al. | Possible induction of cholinesterase in epileptic patients treated with anticonvulsant drugs: relationship with lipoprotein levels. | 2004 | J Clin Pharmacol | pmid:15317825 |
| Toyokuni S | Mysterious link between iron overload and CDKN2A/2B. | 2011 | J Clin Biochem Nutr | pmid:21297911 |
| RICHTER GW | Intranuclear aggregates of ferritin in liver cells of mice treated with saccharated iron oxide. Their possible relation to nuclear protein synthesis. | 1961 | J Biophys Biochem Cytol | pmid:13741388 |
| Moorani KN and Asim S | Parenteral iron sucrose in iron deficiency anaemia of paediatric chronic kidney disease. | 2011 Jul-Sep | J Ayub Med Coll Abbottabad | pmid:23272434 |
| Costa S et al. | In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage. | 2009 | J Appl Toxicol | pmid:18636399 |
| Poon R et al. | HPLC determination of D-glucaric acid in human urine. | 1993 May-Jun | J Anal Toxicol | pmid:8336488 |
| Steinberg KK and Needham LL | A comparison of two methods for quantifying D-glucaric acid. | 1986 Jul-Aug | J Anal Toxicol | pmid:3747452 |