Glucaric acid

Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glucaric acid?

Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glucaric acid

MeSH term MeSH ID Detail
Hemosiderosis D006486 1 associated lipids
Rickets, Hypophosphatemic D063730 1 associated lipids
Calcium Metabolism Disorders D002128 1 associated lipids
Anemia, Neonatal D000751 1 associated lipids
Neurocysticercosis D020019 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Glucaric acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Glucaric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Glucaric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Glucaric acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with Glucaric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glucaric acid?

Knock-out

Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Glucaric acid

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Authors Title Published Journal PubMed Link
Bontchev RP and Moore RC Crystal structure and aqueous solubility of ammonium D-glucarate. 2005 Carbohydr. Res. pmid:16043161
Davey CL et al. Esterification of select polyols with D-glucaric acid as model reactions for esterification of starch. 2006 Carbohydr. Res. pmid:16973136
Ibert M et al. Determination of the side-products formed during the nitroxide-mediated bleach oxidation of glucose to glucaric acid. 2002 Carbohydr. Res. pmid:12039549
Denton TT et al. Characterization of D-glucaric acid using NMR, X-ray crystal structure, and MM3 molecular modeling analyses. 2011 Carbohydr. Res. pmid:22015400
Ibert M et al. Evidence of benzilic rearrangement during the electrochemical oxidation of D-glucose to D-glucaric acid. 2011 Carbohydr. Res. pmid:21269605
Herd JK et al. Synthesis of L-idaro-1,4-lactone, an inhibitor of alpha-L-idosiduronase. 1982 Carbohydr. Res. pmid:7055824
Marsh CA Biosynthesis of D-glucaric acid in mammals: a free-radical mechanism? 1986 Carbohydr. Res. pmid:3779687
Smith TN et al. Modifications in the nitric acid oxidation of D-glucose. 2012 Carbohydr. Res. pmid:22285512
Wargovich MJ et al. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. 2000 Carcinogenesis pmid:10837003
Walaszek Z et al. Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumorigenesis by 2,5-di-O-acetyl-D-glucaro-1,4:6,3-dilactone, an in vivo beta-glucuronidase inhibitor. 1984 Carcinogenesis pmid:6202433
Ball LM et al. Formation of mutagenic urinary metabolites from 1-nitropyrene in germ-free and conventional rats: role of the gut flora. 1991 Carcinogenesis pmid:1988167
Dwivedi C et al. Effects of the experimental chemopreventative agent, glucarate, on intestinal carcinogenesis in rats. 1989 Carcinogenesis pmid:2752528
Walaszek Z et al. Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. 1986 Carcinogenesis pmid:3091283
Wiersema AM et al. Early assessment of skeletal muscle damage after ischaemia-reperfusion injury using Tc-99m-glucarate. 2000 Cardiovasc Surg pmid:10799826
Pecharki GD et al. Effect of sucrose containing iron (II) on dental biofilm and enamel demineralization in situ. 2005 Mar-Apr Caries Res. pmid:15741724
Miyawaki M et al. Absorption of experimentally administered materials by the hepatopancreas cells of the crayfish, Procambarus clarki. 1984 Cell Biol. Int. Rep. pmid:6509562
Olas B et al. D-glucaro 1,4-lactone and resveratrol as antioxidants in blood platelets. 2008 Cell Biol. Toxicol. pmid:17846905
Kao HH et al. Clinical characteristic of parenteral iron supplementation in hemodialysis patients receiving erythropoietin therapy. 2000 Chang Gung Med J pmid:11126152
Lippow SM et al. Engineering enzyme specificity using computational design of a defined-sequence library. 2010 Chem. Biol. pmid:21168766
Tiwari P et al. Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events. 2015 Chem. Biol. Interact. pmid:25478867
Yang W et al. The first fluorescent sensor for D-glucarate based on the cooperative action of boronic acid and guanidinium groups. 2003 Chem. Commun. (Camb.) pmid:12703826
Matsui M et al. Studies on the glucaric acid pathway in the metabolism of D-glucuronic acid in mammals. IV. Fluorometric method for the determination of D-glucaric acid in serum. 1972 Chem. Pharm. Bull. pmid:5065229
Lakatos A et al. AlIII ion complexes of saccharic acid and mucic acid: a solution and solid-state study. 2004 Chemistry pmid:15007818
Verma P et al. Decolorization of synthetic dyes using a copper complex with glucaric acid. 2004 Chemosphere pmid:14575741
Walaszek Z et al. Mechanisms of lung cancer chemoprevention by D-glucarate. 2004 Chest pmid:15136472
Hanausek M et al. Modulation of biomarkers during chemoprevention of mouse lung tumorigenesis by D-glucarate. 2004 Chest pmid:15136473
Narula J et al. Noninvasive detection of atherosclerotic lesions by 99mTc-based immunoscintigraphic targeting of proliferating smooth muscle cells. 1997 Chest pmid:9187194
Sung RY et al. Urinary D-glucaric acid excretion in idiopathic neonatal jaundice. 1996 Chin. Med. J. pmid:8758309
Narula J et al. Very early noninvasive detection of acute experimental nonreperfused myocardial infarction with 99mTc-labeled glucarate. 1997 Circulation pmid:9118528
Dwivedi C et al. Effect of dietary calcium glucarate on 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in CD-1 mice. 1988 Nov-Dec Cleve Clin J Med pmid:3147822
Michigami T [Updates on rickets and osteomalacia: FGF23-mediated hypophosphatemic rickets/osteomalacia]. 2013 Clin Calcium pmid:24076640
Sato K [Drug-induced osteomalacia]. 2007 Clin Calcium pmid:17906405
Agarwal R et al. Proteinuria induced by parenteral iron in chronic kidney disease--a comparative randomized controlled trial. 2011 Clin J Am Soc Nephrol pmid:20876669
Ibrahim HN et al. Parenteral iron use: possible contribution to exceeding target hemoglobin in hemodialysis patients. 2009 Clin J Am Soc Nephrol pmid:19211669
Macdougall IC et al. A randomized comparison of ferumoxytol and iron sucrose for treating iron deficiency anemia in patients with CKD. 2014 Clin J Am Soc Nephrol pmid:24458078
Stancu S et al. Can the response to iron therapy be predicted in anemic nondialysis patients with chronic kidney disease? 2010 Clin J Am Soc Nephrol pmid:20019121
Singh H et al. Effect of intravenous iron sucrose in peritoneal dialysis patients who receive erythropoiesis-stimulating agents for anemia: a randomized, controlled trial. 2006 Clin J Am Soc Nephrol pmid:17699248
Bishu K and Agarwal R Acute injury with intravenous iron and concerns regarding long-term safety. 2006 Clin J Am Soc Nephrol pmid:17699372
Zager RA Parenteral iron compounds: potent oxidants but mainstays of anemia management in chronic renal disease. 2006 Clin J Am Soc Nephrol pmid:17699373
Michaud L et al. Tolerance and efficacy of intravenous iron saccharate for iron deficiency anemia in children and adolescents receiving long-term parenteral nutrition. 2002 Clin Nutr pmid:12381338
Park BK and Breckenridge AM Clinical implications of enzyme induction and enzyme inhibition. 1981 Jan-Feb Clin Pharmacokinet pmid:6113907
Hunter J et al. Urinary d-glucaric acid excretion as a measure of hepatic enzyme induction in man. 1971 Clin Sci pmid:5550888
Davidson DC et al. Assessment of plasma glutamyl transpeptidase activity and urinary D-glucaric acid excretion as indices of enzyme induction. 1974 Clin Sci Mol Med pmid:4154014
Pistelli A et al. [Contribution of glutathione to detoxification in alcoholism. Biochemical-clinical studies]. 1992 Clin Ter pmid:1358498
Pai AB et al. Effect of intravenous iron supplementation on hepatic cytochrome P450 3A4 activity in hemodialysis patients: a prospective, open-label study. 2007 Clin Ther pmid:18201586
Borawski J et al. Endothelial injury markers with high-dose intravenous iron therapy in renal failure. 2004 Clin. Appl. Thromb. Hemost. pmid:15497030
Tutor JC et al. Urinary D-glucaric acid and serum hepatic enzyme levels in chronic alcoholics. 1988 Clin. Biochem. pmid:2898981
March J et al. Values for urinary excretion of D-glucaric acid by normal individuals. 1974 Clin. Chem. pmid:4416840
Tutor JC et al. Serum copper concentration and hepatic enzyme induction during long-term therapy with anticonvulsants. 1982 Clin. Chem. pmid:6122516
Herzberg M and Wiener MH Increased D-glucaric acid excretion by jaundiced patients. 1978 Clin. Chem. pmid:699285