Glucaric acid is a lipid of Fatty Acyls (FA) class. Glucaric acid is associated with abnormalities such as Consumption-archaic term for TB and furuncle. The involved functions are known as Oxidation, Mutation, Process, Cell Growth and Anabolism. Glucaric acid often locates in BL21, Clone and host. The associated genes with Glucaric acid are MIOX gene, ISYNA1 gene, Genome and Candidate Disease Gene. The related experimental models are Knock-out.
To understand associated biological information of Glucaric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucaric acid is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Glucaric acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Glucaric acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Evolution-guided optimization of biosynthetic pathways.' (Raman S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
pmid:10050710 | ||||
pmid:10050711 | ||||
Mezey E | Increased urinary excretion of D-glucaric acid in alcoholism. | 1976 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1005917 |
Warrander A and Waring RH | An improved method for gas chromatographic determination of urinary xylitol and glucuronic, glucaric gulonic and ascorbic acids, with their values in the rat, rabbit, guinea-pig and marmoset. | 1978 | Xenobiotica | pmid:102085 |
Nakatsugawa S et al. | Inhibitory effect of ND2001 on spontaneous multiple metastasis of NC 65 tumors derived from human renal cancer cells intradermally transplanted into nude mice. | 1999 | Anticancer Drugs | pmid:10211554 |
Latham AN and Sweeney GD | Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of induction of hepatic microsomal enzymes. | 1976 | Can. J. Physiol. Pharmacol. | pmid:1021219 |
pmid:10233353 | ||||
Düllmann J et al. | [Iron storage and metabolism in nacrophages and endothelial cells after intravenous administration of colloidal ferric saccharate in man]. | 1976 | Verh Anat Ges | pmid:1024396 |
Rycroft D and Daniel JW | The excretion of D-glucaric acid in the urine of human volunteers following the administration of disopyramide. | 1976 | J. Int. Med. Res. | pmid:1026531 |
Weisbach V et al. | Oral or intravenous iron as an adjuvant to autologous blood donation in elective surgery: a randomized, controlled study. | 1999 | Transfusion | pmid:10335995 |
Gasche C et al. | Sequential treatment of anemia in ulcerative colitis with intravenous iron and erythropoietin. | 1999 | Digestion | pmid:10343140 |
Picaud JC et al. | [Iron supplementation in preterm infants treated with erythropoietin]. | 1999 | Arch Pediatr | pmid:10394459 |
Krafft A et al. | Erythropoietic quality of maternal milk. | 1999 | Lancet | pmid:10475225 |
Lim PS et al. | Enhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy. | 1999 | Nephrol. Dial. Transplant. | pmid:10534512 |
Mariani G et al. | Detection of acute myocardial infarction by 99mTc-labeled D-glucaric acid imaging in patients with acute chest pain. | 1999 | J. Nucl. Med. | pmid:10565778 |
Lubberink M et al. | Quantification aspects of patient studies with 52Fe in positron emission tomography. | 1999 | Appl Radiat Isot | pmid:10581681 |
Yoshimi N et al. | Inhibition of azoxymethane-induced rat colon carcinogenesis by potassium hydrogen D-glucarate. | 2000 | Int. J. Oncol. | pmid:10601547 |
Braun L et al. | Different induction of gulonolactone oxidase in aromatic hydrocarbon-responsive or -unresponsive mouse strains. | 1999 | FEBS Lett. | pmid:10606751 |
Jahn M et al. | The reaction of hyaluronic acid and its monomers, glucuronic acid and N-acetylglucosamine, with reactive oxygen species. | 1999 | Carbohydr. Res. | pmid:10614067 |
Bailie GR et al. | Parenteral iron use in the management of anemia in end-stage renal disease patients. | 2000 | Am. J. Kidney Dis. | pmid:10620537 |
Descombes E and Fellay G | Improved response to erythropoietin therapy with long-term continuous iron supplementation. | 2000 | Nephron | pmid:10657727 |
Fujii Y et al. | Inhibition of liver metastases and tumor cell invasion in spontaneous liver metastasis model (LMFS) by sodium D-glucaro-delta-lactam (ND2001). | 2000 | Biomed. Pharmacother. | pmid:10759292 |
Monterrubio R et al. | A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli. | 2000 | J. Bacteriol. | pmid:10762278 |
Gulick AM et al. | Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli. | 2000 | Biochemistry | pmid:10769114 |
Wiersema AM et al. | Early assessment of skeletal muscle damage after ischaemia-reperfusion injury using Tc-99m-glucarate. | 2000 | Cardiovasc Surg | pmid:10799826 |
Fujita K et al. | Establishment of Salmonella strain expressing catalytically active human UDP-glucuronosyltransferase 1A1 (UGT1A1). | 2000 | Life Sci. | pmid:10821120 |
Wargovich MJ et al. | Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. | 2000 | Carcinogenesis | pmid:10837003 |
Lai AA and Levy RH | Pharmacokinetic description of drug interactions by enzyme induction: carbamazepine-clonazepam in monkeys. | 1979 | J Pharm Sci | pmid:108383 |
Van Wyck DB et al. | Safety and efficacy of iron sucrose in patients sensitive to iron dextran: North American clinical trial. | 2000 | Am. J. Kidney Dis. | pmid:10873877 |
Gombotz H et al. | Preoperative treatment with recombinant human erythropoietin or predeposit of autologous blood in women undergoing primary hip replacement. | 2000 | Acta Anaesthesiol Scand | pmid:10903019 |
Krafft A et al. | Intravenous iron sucrose in two pregnant women with inflammatory bowel disease and severe iron deficiency anemia. | 2000 | Acta Obstet Gynecol Scand | pmid:10949245 |
van Iperen CE et al. | Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients. | 2000 | Crit. Care Med. | pmid:10966249 |
Matsuo E et al. | Acid mucopolysaccharide metabolism in leprosy. 3. Hyaluronic acid mycobacterial growth enhancement, and growth suppression by saccharic acid and vitamin C as inhibitors of beta-glucuronidase. | 1975 Jan-Mar | Int. J. Lepr. Other Mycobact. Dis. | pmid:1099016 |
Parkkinen J et al. | Catalytically active iron and bacterial growth in serum of haemodialysis patients after i.v. iron-saccharate administration. | 2000 | Nephrol. Dial. Transplant. | pmid:11071973 |
Kao HH et al. | Clinical characteristic of parenteral iron supplementation in hemodialysis patients receiving erythropoietin therapy. | 2000 | Chang Gung Med J | pmid:11126152 |
Fishbane S and Kowalski EA | The comparative safety of intravenous iron dextran, iron saccharate, and sodium ferric gluconate. | 2000 Nov-Dec | Semin Dial | pmid:11130261 |
Pollak A et al. | Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants. | 2001 | Pediatrics | pmid:11134438 |
Johnson LL et al. | Technetium-99m glucarate uptake in a swine model of limited flow plus increased demand. | 2000 Nov-Dec | J Nucl Cardiol | pmid:11144474 |
Charytan C et al. | Efficacy and safety of iron sucrose for iron deficiency in patients with dialysis-associated anemia: North American clinical trial. | 2001 | Am. J. Kidney Dis. | pmid:11157370 |
pmid:11217959 | ||||
Kosch M and Schaefer RM | [Iron deficiency. When parenteral substitution?]. | 2001 | MMW Fortschr Med | pmid:11247361 |
Breymann C et al. | Efficacy and safety of intravenously administered iron sucrose with and without adjuvant recombinant human erythropoietin for the treatment of resistant iron-deficiency anemia during pregnancy. | 2001 | Am. J. Obstet. Gynecol. | pmid:11262469 |
pmid:11273875 | ||||
Stoves J et al. | A randomized study of oral vs intravenous iron supplementation in patients with progressive renal insufficiency treated with erythropoietin. | 2001 | Nephrol. Dial. Transplant. | pmid:11328902 |
Talafant E et al. | Glucaric acid excretion as index of hepatic glucuronidation in neonates after phenobarbital treatment. | 1975 | Pediatr. Res. | pmid:1134846 |
Levy G et al. | Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. | 1975 | Pediatrics | pmid:1134883 |
pmid:11390726 | ||||
Pach J et al. | New possibilities in scintigraphy detection of carbon monoxide cardiotoxicity. | 2001 | Prz. Lek. | pmid:11450331 |
Prakash S et al. | Experience with a large dose (500 mg) of intravenous iron dextran and iron saccharate in peritoneal dialysis patients. | 2001 May-Jun | Perit Dial Int | pmid:11475345 |