| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
1-Oleoyl Lysophosphatidic Acid
1-Oleoyl Lysophosphatidic Acid is a lipid of Glycerophospholipids (GP) class. 1-oleoyl lysophosphatidic acid is associated with abnormalities such as Myocardial Infarction, early pregnancy, Scleroderma, Blind Vision and Hyperlipidemia. The involved functions are known as Agent, Blood coagulation, Selection, Genetic, Analyte and Biological Processes. 1-oleoyl lysophosphatidic acid often locates in Tissue specimen, Body tissue, Blood, Membrane and Skin. The associated genes with 1-Oleoyl Lysophosphatidic Acid are Mucin-16, Peptides, SMAD4 gene, RND1 gene and Polypeptides. The related lipids are lysophosphatidic acid, A(2)C, Lysophospholipids, Fatty Acids and sphingosine 1-phosphate. The related experimental models are Mouse Model, Knock-out, Cancer Model, Xenograft Model and Arthritis, Adjuvant-Induced.
Cross Reference
Introduction
To understand associated biological information of 1-Oleoyl Lysophosphatidic Acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 1-Oleoyl Lysophosphatidic Acid?
1-Oleoyl Lysophosphatidic Acid is suspected in Senile Plaques, Atherosclerosis, Asthma, Cardiovascular Diseases, Dyslipidemias, early pregnancy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 1-Oleoyl Lysophosphatidic Acid
PubChem Associated disorders and diseases
What pathways are associated with 1-Oleoyl Lysophosphatidic Acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 1-Oleoyl Lysophosphatidic Acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 1-Oleoyl Lysophosphatidic Acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 1-Oleoyl Lysophosphatidic Acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 1-Oleoyl Lysophosphatidic Acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 1-Oleoyl Lysophosphatidic Acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 1-Oleoyl Lysophosphatidic Acid?
Mouse Model
Mouse Model are used in the study 'Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice.' (Li H et al., 2009), Mouse Model are used in the study 'Lysophosphatidic acid signaling may initiate fetal hydrocephalus.' (Yung YC et al., 2011), Mouse Model are used in the study 'LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.' (Sakai N et al., 2013), Mouse Model are used in the study 'Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma.' (Su SC et al., 2013) and Mouse Model are used in the study 'NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.' (Murtazina R et al., 2011).
Knock-out
Knock-out are used in the study 'Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor.' (Urs NM et al., 2008), Knock-out are used in the study 'Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.' (Liu S et al., 2004), Knock-out are used in the study 'Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.' (Li H et al., 2005), Knock-out are used in the study 'Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.' (van Meeteren LA et al., 2006) and Knock-out are used in the study 'Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.' (Hama K et al., 2004).
Xenograft Model
Xenograft Model are used in the study 'Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma.' (Su SC et al., 2013), Xenograft Model are used in the study 'Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.' (Chen H et al., 2010), Xenograft Model are used in the study 'Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo.' (Zhang H et al., 2009) and Xenograft Model are used in the study 'Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.' (Mukherjee A et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 1-Oleoyl Lysophosphatidic Acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang J et al. | Plasma lipidomic signatures of spontaneous obese rhesus monkeys. | 2019 | Lipids Health Dis | pmid:30621707 |
| Lei L et al. | The role of lysophosphatidic acid in the physiology and pathology of the skin. | 2019 | Life Sci. | pmid:30584899 |
| Schmid R et al. | ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro. | 2018 | BMC Cancer | pmid:30567518 |
| Esmaeili A and Namazi S | Is melatonin effective for pruritus caused by liver disease? | 2018 | Med. Hypotheses | pmid:30396475 |
| Inoue M et al. | Addition of high load of lysophosphatidic acid to standard and high-fat chows causes no significant changes of its circulating and peripheral tissue levels but affects body weight and visceral fat mass of mice. | 2018 | Biofactors | pmid:30368958 |
| Schoeman JC et al. | Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress. | 2018 | Anal Bioanal Chem | pmid:29497765 |
| Zhou T et al. | Lysophosphatidic Acid Induces Ligamentum Flavum Hypertrophy Through the LPAR1/Akt Pathway. | 2018 | Cell. Physiol. Biochem. | pmid:29466791 |
| Hidaka M et al. | Three lysophosphatidic acids with a distinct long chain moiety differently affect cell differentiation of human colon epithelial cells to goblet cells. | 2018 | Life Sci. | pmid:29412173 |
| Schneider P et al. | Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders. | 2018 | Behav. Brain Res. | pmid:28843862 |
| Tsukahara R et al. | LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. | 2018 | J. Pharmacol. Sci. | pmid:29409686 |