1-Oleoyl Lysophosphatidic Acid

1-Oleoyl Lysophosphatidic Acid is a lipid of Glycerophospholipids (GP) class. 1-oleoyl lysophosphatidic acid is associated with abnormalities such as Myocardial Infarction, early pregnancy, Scleroderma, Blind Vision and Hyperlipidemia. The involved functions are known as Agent, Blood coagulation, Selection, Genetic, Analyte and Biological Processes. 1-oleoyl lysophosphatidic acid often locates in Tissue specimen, Body tissue, Blood, Membrane and Skin. The associated genes with 1-Oleoyl Lysophosphatidic Acid are Mucin-16, Peptides, SMAD4 gene, RND1 gene and Polypeptides. The related lipids are lysophosphatidic acid, A(2)C, Lysophospholipids, Fatty Acids and sphingosine 1-phosphate. The related experimental models are Mouse Model, Knock-out, Cancer Model, Xenograft Model and Arthritis, Adjuvant-Induced.

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Introduction

To understand associated biological information of 1-Oleoyl Lysophosphatidic Acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 1-Oleoyl Lysophosphatidic Acid?

1-Oleoyl Lysophosphatidic Acid is suspected in Senile Plaques, Atherosclerosis, Asthma, Cardiovascular Diseases, Dyslipidemias, early pregnancy and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 1-Oleoyl Lysophosphatidic Acid

PubChem Associated disorders and diseases

What pathways are associated with 1-Oleoyl Lysophosphatidic Acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 1-Oleoyl Lysophosphatidic Acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 1-Oleoyl Lysophosphatidic Acid?

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What functions are associated with 1-Oleoyl Lysophosphatidic Acid?


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What lipids are associated with 1-Oleoyl Lysophosphatidic Acid?

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What genes are associated with 1-Oleoyl Lysophosphatidic Acid?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 1-Oleoyl Lysophosphatidic Acid?

Mouse Model

Mouse Model are used in the study 'Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice.' (Li H et al., 2009), Mouse Model are used in the study 'Lysophosphatidic acid signaling may initiate fetal hydrocephalus.' (Yung YC et al., 2011), Mouse Model are used in the study 'LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.' (Sakai N et al., 2013), Mouse Model are used in the study 'Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma.' (Su SC et al., 2013) and Mouse Model are used in the study 'NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.' (Murtazina R et al., 2011).

Knock-out

Knock-out are used in the study 'Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptor.' (Urs NM et al., 2008), Knock-out are used in the study 'Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.' (Liu S et al., 2004), Knock-out are used in the study 'Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.' (Li H et al., 2005), Knock-out are used in the study 'Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.' (van Meeteren LA et al., 2006) and Knock-out are used in the study 'Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.' (Hama K et al., 2004).

Xenograft Model

Xenograft Model are used in the study 'Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma.' (Su SC et al., 2013), Xenograft Model are used in the study 'Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.' (Chen H et al., 2010), Xenograft Model are used in the study 'Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo.' (Zhang H et al., 2009) and Xenograft Model are used in the study 'Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.' (Mukherjee A et al., 2012).

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NCBI Entrez Crosslinks

All references with 1-Oleoyl Lysophosphatidic Acid

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Authors Title Published Journal PubMed Link
Wang J et al. Plasma lipidomic signatures of spontaneous obese rhesus monkeys. 2019 Lipids Health Dis pmid:30621707
Lei L et al. The role of lysophosphatidic acid in the physiology and pathology of the skin. 2019 Life Sci. pmid:30584899
Zhou ZB et al. Lysophosphatidic Acid Promotes Expression and Activation of Matrix Metalloproteinase 9 (MMP9) in THP-1 Cells via Toll-Like Receptor 4/Nuclear Factor-κB (TLR4/NF-κB) Signaling Pathway. 2018 Med. Sci. Monit. pmid:30005060
Zhu X et al. Early development of porcine parthenogenetic embryos and reduced expression of primed pluripotent marker genes under the effect of lysophosphatidic acid. 2018 Reprod. Domest. Anim. pmid:29974990
Broström JM et al. Toluene diisocyanate exposure and autotaxin-lysophosphatidic acid signalling. 2018 Toxicol. Appl. Pharmacol. pmid:29940203
Ueda H et al. Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain. 2018 Pain pmid:29939962
Ramesh S et al. Autotaxin⁻Lysophosphatidic Acid Signaling in Alzheimer's Disease. 2018 Int J Mol Sci pmid:29933579
Baader M et al. Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis. 2018 Br. J. Pharmacol. pmid:29197066
Takeda T et al. In vivo evidence for possible up-regulating roles of lysophosphatidic acid around fertilization in rats. 2018 J. Vet. Med. Sci. pmid:29162771
Szepanowski F et al. Lysophosphatidic acid propagates post-injury Schwann cell dedifferentiation through LPA signaling. 2018 Neurosci. Lett. pmid:29051083