POV-PC

POV-PC is a lipid of Glycerophospholipids (GP) class. Pov-pc is associated with abnormalities such as Atherosclerosis, Coronary Artery Disease, BOSLEY-SALIH-ALORAINY SYNDROME, Coronary Arteriosclerosis and Hypercholesterolemia. The involved functions are known as Metabolic Inhibition, Binding (Molecular Function), Tissue Adhesions, Oxidation and Cell Communication. Pov-pc often locates in Endothelium, Arterial system, Membrane, Cell surface and Plasma membrane. The associated genes with POV-PC are PCDH8 gene, CS1 peptide, MYOZ2 gene, SLC33A1 gene and Genes, Reporter. The related lipids are oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine, 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine, oxidized lipid, LYSO-PC and Lipopolysaccharides. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of POV-PC, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with POV-PC?

POV-PC is suspected in BOSLEY-SALIH-ALORAINY SYNDROME, Coronary Arteriosclerosis, Atherosclerosis, Coronary Artery Disease, Hypercholesterolemia, Hereditary pancreatitis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with POV-PC

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with POV-PC

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with POV-PC?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with POV-PC?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with POV-PC?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with POV-PC?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with POV-PC?

Knock-out

Knock-out are used in the study 'Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration.' (Cherepanova OA et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with POV-PC

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Authors Title Published Journal PubMed Link
Ayee MAA et al. Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids. 2017 Biophys. J. pmid:28122218
Yeon SH et al. Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages. 2017 J. Leukoc. Biol. pmid:27256568
Yan FX et al. The oxidized phospholipid POVPC impairs endothelial function and vasodilation via uncoupling endothelial nitric oxide synthase. 2017 J. Mol. Cell. Cardiol. pmid:28870504
Ademowo OS et al. Phospholipid oxidation and carotenoid supplementation in Alzheimer's disease patients. 2017 Free Radic. Biol. Med. pmid:28315450
Barbour SE and Ramanadham S Analyses of Calcium-Independent Phospholipase Abeta (iPLAβ) in Biological Systems. 2017 Meth. Enzymol. pmid:28063488
Vogl F et al. Role of protein kinase C δ in apoptotic signaling of oxidized phospholipids in RAW 264.7 macrophages. 2016 Biochim. Biophys. Acta pmid:26707247
Stokes CA et al. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. 2016 Mucosal Immunol pmid:26906404
Brameshuber M et al. Oxidized Phospholipids Inhibit the Formation of Cholesterol-Dependent Plasma Membrane Nanoplatforms. 2016 Biophys. J. pmid:26745423
Ramprecht C et al. Toxicity of oxidized phosphatidylcholines in cultured human melanoma cells. 2015 Chem. Phys. Lipids pmid:26028612
Vinetti G et al. Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes: a randomized controlled trial. 2015 Sci Rep pmid:25783765