MeSH term | MeSH ID | Detail |
---|---|---|
Biliary Fistula | D001658 | 13 associated lipids |
Leukemia, Myeloid | D007951 | 52 associated lipids |
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
MeSH term | MeSH ID | Detail |
---|---|---|
Biliary Fistula | D001658 | 13 associated lipids |
Leukemia, Myeloid | D007951 | 52 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Molina S et al. | The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus. | 2007 | J. Hepatol. | pmid:17156886 |
Brusselmans K et al. | Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. | 2007 | J. Biol. Chem. | pmid:17483544 |
Daicho K et al. | The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast. | 2007 | Biochim. Biophys. Acta | pmid:17531951 |
Wilson R et al. | Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide. | 2007 | BMC Neurosci | pmid:18034899 |
Bedi M et al. | Inhibition of squalene synthase upregulates PCSK9 expression in rat liver. | 2008 | Arch. Biochem. Biophys. | pmid:18054775 |
Lasserre R et al. | Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. | 2008 | Nat. Chem. Biol. | pmid:18641634 |
Rothwell C et al. | Cholesterol biosynthesis modulation regulates dengue viral replication. | 2009 | Virology | pmid:19419745 |
Vukelic S et al. | Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. | 2010 | J. Biol. Chem. | pmid:19903814 |
Linetti A et al. | Cholesterol reduction impairs exocytosis of synaptic vesicles. | 2010 | J. Cell. Sci. | pmid:20103534 |
Kojro E et al. | Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis. | 2010 | J. Alzheimers Dis. | pmid:20413873 |