Bamford MJ et al. |
The squalestatins: synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality. |
1995 |
J. Med. Chem. |
pmid:7658437
|
Lindsey S and Harwood HJ |
Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation. |
1995 |
J. Biol. Chem. |
pmid:7721822
|
Doerner KC et al. |
Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. |
1995 |
J. Lipid Res. |
pmid:7665995
|
Bergstrom JD et al. |
Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase. |
1995 |
Annu. Rev. Microbiol. |
pmid:8561474
|
Soltis DA et al. |
Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems. |
1995 |
Arch. Biochem. Biophys. |
pmid:7864626
|
Fulton DC et al. |
Comparative study of the inhibition of rat and tobacco squalene synthase by squalestatins. |
1995 |
Phytochemistry |
pmid:7766395
|
Thelin A et al. |
Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. |
1994 |
Biochim. Biophys. Acta |
pmid:7811707
|
Procopiou PA et al. |
The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues. |
1994 |
J. Med. Chem. |
pmid:7932554
|
Chen TS et al. |
The preparation of zaragozic acid A analogues by directed biosynthesis. |
1994 |
J. Antibiot. |
pmid:8002393
|
Correll CC and Edwards PA |
Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. |
1994 |
J. Biol. Chem. |
pmid:8276863
|
Biftu T et al. |
Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition. |
1994 |
J. Med. Chem. |
pmid:8308869
|
Ponpipom MM et al. |
Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. |
1994 |
J. Med. Chem. |
pmid:7966163
|
Bansal VS and Vaidya S |
Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes. |
1994 |
Arch. Biochem. Biophys. |
pmid:7986083
|
Ness GC et al. |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by sterols and nonsterols in rat liver. |
1994 |
Arch. Biochem. Biophys. |
pmid:8109970
|
Cannell RJ et al. |
Production of additional squalestatin analogues by directed biosynthesis. |
1994 |
J. Antibiot. |
pmid:8150722
|
Ness GC et al. |
Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. |
1994 |
Arch. Biochem. Biophys. |
pmid:7911291
|
Gibbs JB et al. |
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. |
1993 |
J. Biol. Chem. |
pmid:8463291
|
Bergstrom JD et al. |
Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. |
1993 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:8419946
|
Hasumi K et al. |
Competitive inhibition of squalene synthetase by squalestatin 1. |
1993 |
J. Antibiot. |
pmid:8501015
|
Dufresne C et al. |
Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. |
1993 |
J. Nat. Prod. |
pmid:8289063
|