MeSH term | MeSH ID | Detail |
---|---|---|
Biliary Fistula | D001658 | 13 associated lipids |
Leukemia, Myeloid | D007951 | 52 associated lipids |
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
MeSH term | MeSH ID | Detail |
---|---|---|
Biliary Fistula | D001658 | 13 associated lipids |
Leukemia, Myeloid | D007951 | 52 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lasserre R et al. | Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. | 2008 | Nat. Chem. Biol. | pmid:18641634 |
Kocarek TA et al. | Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: inhibitors of squalene synthase are potent inducers of CYP2B expression in primary cultured rat hepatocytes and rat liver. | 1998 | Mol. Pharmacol. | pmid:9730906 |
Kocarek TA and Mercer-Haines NA | Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor. | 2002 | Mol. Pharmacol. | pmid:12391282 |
Gardner RG et al. | In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. | 2001 | Mol. Cell. Biol. | pmid:11390656 |
Cannell RJ et al. | Follow-up of natural products isolation. | 2012 | Methods Mol. Biol. | pmid:22367909 |
Michikawa M and Yanagisawa K | Apolipoprotein E4 isoform-specific actions on neuronal cells in culture. | 1999 | Mech. Ageing Dev. | pmid:10360679 |
Stankewich MC et al. | Alterations in cell cholesterol content modulate Ca(2+)-induced tight junction assembly by MDCK cells. | 1996 | Lipids | pmid:8869884 |
Rondini EA et al. | Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes. | 2015 | J. Pharmacol. Exp. Ther. | pmid:26427720 |
Rondini EA et al. | Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27225895 |
Naito S et al. | Novel approach to the zaragozic acids. Enantioselective total synthesis of 6,7-dideoxysqualestatin H5. | 2002 | J. Org. Chem. | pmid:12054955 |