| MeSH term | MeSH ID | Detail |
|---|---|---|
| Biliary Fistula | D001658 | 13 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
Total
2
Zaragozic acid A
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Zaragozic acid A?
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
PubChem Associated disorders and diseases
What pathways are associated with Zaragozic acid A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Zaragozic acid A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Zaragozic acid A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Zaragozic acid A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Zaragozic acid A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Zaragozic acid A?
Mouse Model
Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Zaragozic acid A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pirillo A et al. | Simvastatin modulates the heat shock response and cytotoxicity mediated by oxidized LDL in cultured human endothelial smooth muscle cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070296 |
| Hartmann MA et al. | Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. | 2000 | Biochem. Soc. Trans. | pmid:11171211 |
| Thelin A et al. | Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. | 1994 | Biochim. Biophys. Acta | pmid:7811707 |
| Keller RK | Squalene synthase inhibition alters metabolism of nonsterols in rat liver. | 1996 | Biochim. Biophys. Acta | pmid:8908150 |
| Bentinger M et al. | Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. | 2014 | Biochim. Biophys. Acta | pmid:24747199 |
| Henneman L et al. | Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. | 2011 | Biochim. Biophys. Acta | pmid:21237288 |
| Daicho K et al. | The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast. | 2007 | Biochim. Biophys. Acta | pmid:17531951 |
| McHale-Owen H and Bate C | Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-β oligomers. | 2018 | Biochim. Biophys. Acta | pmid:29247837 |
| Li HY et al. | Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. | 2003 | Blood | pmid:12506040 |
| Wilson R et al. | Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide. | 2007 | BMC Neurosci | pmid:18034899 |
| Corsini A et al. | [Pharmacological control of biosynthesis pathway of mevalonate: effect on the proliferation of arterial smooth muscle cells]. | 1997 | C. R. Seances Soc. Biol. Fil. | pmid:9255346 |
| Lanterna C et al. | The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice. | 2016 | Cancer Immunol. Immunother. | pmid:27520505 |
| Cox RJ et al. | Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis. | 2004 | Chem. Commun. (Camb.) | pmid:15489970 |
| Bonsch B et al. | Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues. | 2016 | Chem. Commun. (Camb.) | pmid:27056201 |
| Liddle E et al. | In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase. | 2017 | Chem. Commun. (Camb.) | pmid:28106181 |
| Wang Y and Metz P | A general access to zaragozic acids: total synthesis and structure elucidation of zaragozic acid D and formal syntheses of zaragozic acids A and C. | 2011 | Chemistry | pmid:21328504 |
| Hirata Y et al. | Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy. | 2006 | Chemistry | pmid:17106907 |
| Pant A and Kocarek TA | Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes. | 2016 | Drug Metab. Dispos. | pmid:26700959 |
| Gardner RG and Hampton RY | A 'distributed degron' allows regulated entry into the ER degradation pathway. | 1999 | EMBO J. | pmid:10545111 |
| Flury I et al. | INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. | 2005 | EMBO J. | pmid:16270032 |