MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Myeloid | D007951 | 52 associated lipids |
Biliary Fistula | D001658 | 13 associated lipids |
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Myeloid | D007951 | 52 associated lipids |
Biliary Fistula | D001658 | 13 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kahlon AK et al. | Molecular docking studies to map the binding site of squalene synthase inhibitors on dehydrosqualene synthase of Staphylococcus aureus. | 2010 | J. Biomol. Struct. Dyn. | pmid:20645653 |
Baxter A et al. | Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo. | 1992 | J. Biol. Chem. | pmid:1601846 |
Correll CC and Edwards PA | Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. | 1994 | J. Biol. Chem. | pmid:8276863 |
Gibbs JB et al. | Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. | 1993 | J. Biol. Chem. | pmid:8463291 |
Bostedor RG et al. | Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. | 1997 | J. Biol. Chem. | pmid:9083051 |
Ravid T et al. | The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2000 | J. Biol. Chem. | pmid:10964918 |
Bate C et al. | Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. | 2004 | J. Biol. Chem. | pmid:14754889 |
Haeuptle MA et al. | Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid. | 2011 | J. Biol. Chem. | pmid:21183681 |
Vukelic S et al. | Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. | 2010 | J. Biol. Chem. | pmid:19903814 |
Brusselmans K et al. | Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. | 2007 | J. Biol. Chem. | pmid:17483544 |