| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
Total
2
Zaragozic acid A
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Zaragozic acid A?
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
PubChem Associated disorders and diseases
What pathways are associated with Zaragozic acid A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Zaragozic acid A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Zaragozic acid A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Zaragozic acid A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Zaragozic acid A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Zaragozic acid A?
Mouse Model
Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Zaragozic acid A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
| Michikawa M and Yanagisawa K | Apolipoprotein E4 isoform-specific actions on neuronal cells in culture. | 1999 | Mech. Ageing Dev. | pmid:10360679 |
| Gardner RG and Hampton RY | A 'distributed degron' allows regulated entry into the ER degradation pathway. | 1999 | EMBO J. | pmid:10545111 |
| Kaneshiro ES et al. | Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. | 2000 | Antimicrob. Agents Chemother. | pmid:10817720 |
| Ravid T et al. | The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2000 | J. Biol. Chem. | pmid:10964918 |
| Freeman-Cook KD and Halcomb RL | A symmetry-based formal synthesis of zaragozic acid A. | 2000 | J. Org. Chem. | pmid:10987953 |
| Hartmann MA et al. | Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. | 2000 | Biochem. Soc. Trans. | pmid:11171211 |
| Gardner RG et al. | In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. | 2001 | Mol. Cell. Biol. | pmid:11390656 |
| Calter MA and Zhu C | Scope and diastereoselectivity of the "interrupted" Feist-Bénary reaction. | 2002 | Org. Lett. | pmid:11796051 |
| Calter MA et al. | Rapid synthesis of the 7-deoxy zaragozic acid core. | 2002 | Org. Lett. | pmid:11796052 |
| Ourlin JC et al. | A Link between cholesterol levels and phenobarbital induction of cytochromes P450. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11846416 |
| Pedretti A et al. | Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. | 2002 | J. Med. Chem. | pmid:11906287 |
| Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
| Naito S et al. | Novel approach to the zaragozic acids. Enantioselective total synthesis of 6,7-dideoxysqualestatin H5. | 2002 | J. Org. Chem. | pmid:12054955 |
| Wentzinger LF et al. | Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. | 2002 | Plant Physiol. | pmid:12226513 |
| Kocarek TA and Mercer-Haines NA | Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor. | 2002 | Mol. Pharmacol. | pmid:12391282 |
| Li HY et al. | Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. | 2003 | Blood | pmid:12506040 |
| Jones CA et al. | The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. III. Biosynthesis. | 1992 | J. Antibiot. | pmid:1429235 |
| Bate C et al. | Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. | 2004 | J. Biol. Chem. | pmid:14754889 |