Zaragozic acid A

Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Zaragozic acid A?

Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Zaragozic acid A

MeSH term MeSH ID Detail
Leukemia, Myeloid D007951 52 associated lipids
Biliary Fistula D001658 13 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Zaragozic acid A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Zaragozic acid A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Zaragozic acid A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Zaragozic acid A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Zaragozic acid A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Zaragozic acid A?

Mouse Model

Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Zaragozic acid A

Download all related citations
Per page 10 20 50 100 | Total 105
Authors Title Published Journal PubMed Link
pmid:
Tong H et al. Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells. 2005 Anal. Biochem. pmid:15582558
Bergstrom JD et al. Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase. 1995 Annu. Rev. Microbiol. pmid:8561474
Kaneshiro ES et al. Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. 2000 Antimicrob. Agents Chemother. pmid:10817720
da Silva MF et al. In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway. 2015 Antimicrob. Agents Chemother. pmid:26055383
Ness GC et al. Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. 1996 Arch. Biochem. Biophys. pmid:8561503
Bansal VS and Vaidya S Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes. 1994 Arch. Biochem. Biophys. pmid:7986083
Vaidya S et al. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. 1998 Arch. Biochem. Biophys. pmid:9647670
Peffley DM and Gayen AK Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. 1997 Arch. Biochem. Biophys. pmid:9016820
Thompson JF et al. Truncation of human squalene synthase yields active, crystallizable protein. 1998 Arch. Biochem. Biophys. pmid:9473303
Soltis DA et al. Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems. 1995 Arch. Biochem. Biophys. pmid:7864626
Ness GC et al. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by sterols and nonsterols in rat liver. 1994 Arch. Biochem. Biophys. pmid:8109970
Bedi M et al. Inhibition of squalene synthase upregulates PCSK9 expression in rat liver. 2008 Arch. Biochem. Biophys. pmid:18054775
Handschin C et al. Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. 2005 Arch. Biochem. Biophys. pmid:15629111
Lopez D et al. Compensatory responses to inhibition of hepatic squalene synthase. 1998 Arch. Biochem. Biophys. pmid:9514656
Ness GC et al. Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. 1994 Arch. Biochem. Biophys. pmid:7911291
Keller RK et al. Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. 1996 Arch. Biochem. Biophys. pmid:8645011
Loike JD et al. Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15345508
Schneiders MS et al. Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency. 2006 Arthritis Rheum. pmid:16802371
Pirillo A et al. Simvastatin modulates the heat shock response and cytotoxicity mediated by oxidized LDL in cultured human endothelial smooth muscle cells. 1997 Biochem. Biophys. Res. Commun. pmid:9070296
Ourlin JC et al. A Link between cholesterol levels and phenobarbital induction of cytochromes P450. 2002 Biochem. Biophys. Res. Commun. pmid:11846416
Hartmann MA et al. Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. 2000 Biochem. Soc. Trans. pmid:11171211
Thelin A et al. Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. 1994 Biochim. Biophys. Acta pmid:7811707
Keller RK Squalene synthase inhibition alters metabolism of nonsterols in rat liver. 1996 Biochim. Biophys. Acta pmid:8908150
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
Henneman L et al. Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. 2011 Biochim. Biophys. Acta pmid:21237288
Daicho K et al. The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast. 2007 Biochim. Biophys. Acta pmid:17531951
McHale-Owen H and Bate C Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-β oligomers. 2018 Biochim. Biophys. Acta pmid:29247837
Li HY et al. Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. 2003 Blood pmid:12506040
Wilson R et al. Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide. 2007 BMC Neurosci pmid:18034899
Corsini A et al. [Pharmacological control of biosynthesis pathway of mevalonate: effect on the proliferation of arterial smooth muscle cells]. 1997 C. R. Seances Soc. Biol. Fil. pmid:9255346
Lanterna C et al. The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice. 2016 Cancer Immunol. Immunother. pmid:27520505
Cox RJ et al. Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis. 2004 Chem. Commun. (Camb.) pmid:15489970
Bonsch B et al. Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues. 2016 Chem. Commun. (Camb.) pmid:27056201
Liddle E et al. In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase. 2017 Chem. Commun. (Camb.) pmid:28106181
Wang Y and Metz P A general access to zaragozic acids: total synthesis and structure elucidation of zaragozic acid D and formal syntheses of zaragozic acids A and C. 2011 Chemistry pmid:21328504
Hirata Y et al. Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy. 2006 Chemistry pmid:17106907
Pant A and Kocarek TA Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes. 2016 Drug Metab. Dispos. pmid:26700959
Gardner RG and Hampton RY A 'distributed degron' allows regulated entry into the ER degradation pathway. 1999 EMBO J. pmid:10545111
Flury I et al. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. 2005 EMBO J. pmid:16270032
Weivoda MM and Hohl RJ Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. 2011 Endocrinology pmid:21586555
Vlahcevic ZR et al. Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. 1997 Gastroenterology pmid:9394735
Paintlia AS et al. Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. 2010 Glia pmid:20578043
Pandak WM et al. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. 2002 Hepatology pmid:12029625
Kojro E et al. Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis. 2010 J. Alzheimers Dis. pmid:20413873
Dawson MJ et al. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. 1992 J. Antibiot. pmid:1624366
Sidebottom PJ et al. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation. 1992 J. Antibiot. pmid:1624367
Chen TS et al. The preparation of zaragozic acid A analogues by directed biosynthesis. 1994 J. Antibiot. pmid:8002393
Hasumi K et al. Competitive inhibition of squalene synthetase by squalestatin 1. 1993 J. Antibiot. pmid:8501015
Onishi JC et al. Antimicrobial activity of viridiofungins. 1997 J. Antibiot. pmid:9186560