| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
Total
2
Zaragozic acid A
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Zaragozic acid A?
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
PubChem Associated disorders and diseases
What pathways are associated with Zaragozic acid A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Zaragozic acid A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Zaragozic acid A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Zaragozic acid A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Zaragozic acid A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Zaragozic acid A?
Mouse Model
Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Zaragozic acid A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rondini EA et al. | Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27225895 |
| Lanterna C et al. | The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice. | 2016 | Cancer Immunol. Immunother. | pmid:27520505 |
| Liddle E et al. | In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase. | 2017 | Chem. Commun. (Camb.) | pmid:28106181 |
| Liu N et al. | Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. | 2017 | Org. Lett. | pmid:28605916 |
| McHale-Owen H and Bate C | Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-β oligomers. | 2018 | Biochim. Biophys. Acta | pmid:29247837 |
| Crick DC et al. | Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. | 1995 | J. Neurochem. | pmid:7643114 |
| Bamford MJ et al. | The squalestatins: synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality. | 1995 | J. Med. Chem. | pmid:7658437 |
| Doerner KC et al. | Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. | 1995 | J. Lipid Res. | pmid:7665995 |
| Lindsey S and Harwood HJ | Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation. | 1995 | J. Biol. Chem. | pmid:7721822 |
| Fulton DC et al. | Comparative study of the inhibition of rat and tobacco squalene synthase by squalestatins. | 1995 | Phytochemistry | pmid:7766395 |
| Middleton RF et al. | Novel squalestatins produced by biotransformation. | 1995 | J. Antibiot. | pmid:7775268 |
| Thelin A et al. | Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. | 1994 | Biochim. Biophys. Acta | pmid:7811707 |
| Kelly MJ and Roberts SM | Synthetic chemistry. Combating cholesterol. | 1995 | Nature | pmid:7816124 |
| Soltis DA et al. | Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems. | 1995 | Arch. Biochem. Biophys. | pmid:7864626 |
| Ness GC et al. | Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. | 1994 | Arch. Biochem. Biophys. | pmid:7911291 |
| Procopiou PA et al. | The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues. | 1994 | J. Med. Chem. | pmid:7932554 |
| Ponpipom MM et al. | Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. | 1994 | J. Med. Chem. | pmid:7966163 |
| Bansal VS and Vaidya S | Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes. | 1994 | Arch. Biochem. Biophys. | pmid:7986083 |
| Chen TS et al. | The preparation of zaragozic acid A analogues by directed biosynthesis. | 1994 | J. Antibiot. | pmid:8002393 |
| Ness GC et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by sterols and nonsterols in rat liver. | 1994 | Arch. Biochem. Biophys. | pmid:8109970 |