| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
Total
2
Zaragozic acid A
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Zaragozic acid A?
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
PubChem Associated disorders and diseases
What pathways are associated with Zaragozic acid A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Zaragozic acid A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Zaragozic acid A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Zaragozic acid A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Zaragozic acid A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Zaragozic acid A?
Mouse Model
Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Zaragozic acid A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Michikawa M and Yanagisawa K | Apolipoprotein E4 isoform-specific actions on neuronal cells in culture. | 1999 | Mech. Ageing Dev. | pmid:10360679 |
| Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
| Thompson JF et al. | Truncation of human squalene synthase yields active, crystallizable protein. | 1998 | Arch. Biochem. Biophys. | pmid:9473303 |
| Kocarek TA et al. | Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: inhibitors of squalene synthase are potent inducers of CYP2B expression in primary cultured rat hepatocytes and rat liver. | 1998 | Mol. Pharmacol. | pmid:9730906 |
| Lopez D et al. | Compensatory responses to inhibition of hepatic squalene synthase. | 1998 | Arch. Biochem. Biophys. | pmid:9514656 |
| Corsini A et al. | [Pharmacological control of biosynthesis pathway of mevalonate: effect on the proliferation of arterial smooth muscle cells]. | 1997 | C. R. Seances Soc. Biol. Fil. | pmid:9255346 |
| Onishi JC et al. | Antimicrobial activity of viridiofungins. | 1997 | J. Antibiot. | pmid:9186560 |
| Pirillo A et al. | Simvastatin modulates the heat shock response and cytotoxicity mediated by oxidized LDL in cultured human endothelial smooth muscle cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070296 |
| Bostedor RG et al. | Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. | 1997 | J. Biol. Chem. | pmid:9083051 |
| Peffley DM and Gayen AK | Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. | 1997 | Arch. Biochem. Biophys. | pmid:9016820 |
| Vlahcevic ZR et al. | Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. | 1997 | Gastroenterology | pmid:9394735 |
| Procopiou PA et al. | The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues. | 1996 | J. Med. Chem. | pmid:8691471 |
| Ness GC et al. | Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. | 1996 | Arch. Biochem. Biophys. | pmid:8561503 |
| Keller RK | Squalene synthase inhibition alters metabolism of nonsterols in rat liver. | 1996 | Biochim. Biophys. Acta | pmid:8908150 |
| Stankewich MC et al. | Alterations in cell cholesterol content modulate Ca(2+)-induced tight junction assembly by MDCK cells. | 1996 | Lipids | pmid:8869884 |
| Chan C et al. | The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. | 1996 | J. Med. Chem. | pmid:8568810 |
| Keller RK et al. | Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. | 1996 | Arch. Biochem. Biophys. | pmid:8645011 |
| Middleton RF et al. | Novel squalestatins produced by biotransformation. | 1995 | J. Antibiot. | pmid:7775268 |
| Bamford MJ et al. | The squalestatins: synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality. | 1995 | J. Med. Chem. | pmid:7658437 |
| Lindsey S and Harwood HJ | Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation. | 1995 | J. Biol. Chem. | pmid:7721822 |