MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Myeloid | D007951 | 52 associated lipids |
Biliary Fistula | D001658 | 13 associated lipids |
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Myeloid | D007951 | 52 associated lipids |
Biliary Fistula | D001658 | 13 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Weivoda MM and Hohl RJ | Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. | 2011 | Endocrinology | pmid:21586555 |
Vlahcevic ZR et al. | Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. | 1997 | Gastroenterology | pmid:9394735 |
Paintlia AS et al. | Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. | 2010 | Glia | pmid:20578043 |
Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
Kojro E et al. | Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis. | 2010 | J. Alzheimers Dis. | pmid:20413873 |
Dawson MJ et al. | The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. | 1992 | J. Antibiot. | pmid:1624366 |
Sidebottom PJ et al. | The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation. | 1992 | J. Antibiot. | pmid:1624367 |
Chen TS et al. | The preparation of zaragozic acid A analogues by directed biosynthesis. | 1994 | J. Antibiot. | pmid:8002393 |
Hasumi K et al. | Competitive inhibition of squalene synthetase by squalestatin 1. | 1993 | J. Antibiot. | pmid:8501015 |
Onishi JC et al. | Antimicrobial activity of viridiofungins. | 1997 | J. Antibiot. | pmid:9186560 |