MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Myeloid | D007951 | 52 associated lipids |
Biliary Fistula | D001658 | 13 associated lipids |
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Myeloid | D007951 | 52 associated lipids |
Biliary Fistula | D001658 | 13 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Thelin A et al. | Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. | 1994 | Biochim. Biophys. Acta | pmid:7811707 |
Daicho K et al. | The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast. | 2007 | Biochim. Biophys. Acta | pmid:17531951 |
McHale-Owen H and Bate C | Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-β oligomers. | 2018 | Biochim. Biophys. Acta | pmid:29247837 |
Hartmann MA et al. | Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. | 2000 | Biochem. Soc. Trans. | pmid:11171211 |
Pirillo A et al. | Simvastatin modulates the heat shock response and cytotoxicity mediated by oxidized LDL in cultured human endothelial smooth muscle cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070296 |
Ourlin JC et al. | A Link between cholesterol levels and phenobarbital induction of cytochromes P450. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11846416 |
Schneiders MS et al. | Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency. | 2006 | Arthritis Rheum. | pmid:16802371 |
Loike JD et al. | Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15345508 |
Ness GC et al. | Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. | 1996 | Arch. Biochem. Biophys. | pmid:8561503 |
Bansal VS and Vaidya S | Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes. | 1994 | Arch. Biochem. Biophys. | pmid:7986083 |