| MeSH term | MeSH ID | Detail |
|---|---|---|
| Goldenhar Syndrome | D006053 | 1 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Adenomyosis | D062788 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Han Y et al. | Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors. | 2015 | Exp. Cell Res. | pmid:25933513 |
| Mishra DR et al. | Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. | 2015 | PLoS ONE | pmid:25923237 |
| Toscano MG et al. | SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. | 2015 | Mol. Ther. | pmid:25292191 |
| Zhao W et al. | A traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation. | 2015 | J Chin Med Assoc | pmid:25913212 |
| Lin S et al. | IL-4 Modulates Macrophage Polarization in Ankylosing Spondylitis. | 2015 | Cell. Physiol. Biochem. | pmid:25896783 |
| Di Zanni E et al. | Identification of novel pathways and molecules able to down-regulate PHOX2B gene expression by in vitro drug screening approaches in neuroblastoma cells. | 2015 | Exp. Cell Res. | pmid:25882494 |
| Nordström L et al. | DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. | 2015 | BMC Cancer | pmid:25880212 |
| Samiec M et al. | Trichostatin A-mediated epigenetic transformation of adult bone marrow-derived mesenchymal stem cells biases the in vitro developmental capability, quality, and pluripotency extent of porcine cloned embryos. | 2015 | Biomed Res Int | pmid:25866813 |
| Hou H et al. | Influence of intra-articular administration of trichostatin a on autologous osteochondral transplantation in a rabbit model. | 2015 | Biomed Res Int | pmid:25866784 |
| Devaney JM et al. | Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. | 2015 | Epigenetics | pmid:25864488 |
| Ganatra DA et al. | Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells. | 2015 | Eye (Lond) | pmid:25853442 |
| Tao W et al. | Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. | 2015 | Mol. Pharmacol. | pmid:25852071 |
| Bieluszewski T et al. | AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. | 2015 | BMC Plant Biol. | pmid:25849764 |
| Martini M et al. | Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation. | 2015 | Mediators Inflamm. | pmid:26491230 |
| Mizutani E et al. | Generation of cloned mice from adult neurons by direct nuclear transfer. | 2015 | Biol. Reprod. | pmid:25653280 |
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| Shah S et al. | Impact of viral activators and epigenetic regulators on HIV-1 LTRs containing naturally occurring single nucleotide polymorphisms. | 2015 | Biomed Res Int | pmid:25629043 |
| Zhang Q et al. | Trichostatin A Protects Against Experimental Acute-on-Chronic Liver Failure in Rats Through Regulating the Acetylation of Nuclear Factor-κB. | 2015 | Inflammation | pmid:25604312 |
| Zhang F et al. | Assessment of the effect of trichostatin A on HeLa cells through FT-IR spectroscopy. | 2015 | Anal. Chem. | pmid:25602746 |
| Adi Harel S et al. | Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth. | 2015 | Cell Death Differ. | pmid:25591738 |
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| Tiernan AR et al. | Trichostatin A affects the secretion pathways of beta and intestinal endocrine cells. | 2015 | Exp. Cell Res. | pmid:25305500 |
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| Brandão FA et al. | Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. | 2015 | Virulence | pmid:26103530 |
| Sugimoto H et al. | Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits. | 2015 | Zygote | pmid:24666637 |
| Ma L et al. | HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1. | 2015 | Mol. Endocrinol. | pmid:26357899 |
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| Barr MP et al. | VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach. | 2015 | Epigenomics | pmid:26479311 |
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| Cai D et al. | Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis. | 2015 | Arthritis Res. Ther. | pmid:26408027 |
| Rolando M et al. | Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery. | 2015 | Cytoskeleton (Hoboken) | pmid:26403219 |
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| Liao HF et al. | Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. | 2015 | Reproduction | pmid:26159833 |
| Vadie N et al. | MYCNOS functions as an antisense RNA regulating MYCN. | 2015 | RNA Biol | pmid:26156430 |
| Ota C et al. | Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. | 2015 | Exp. Lung Res. | pmid:26151196 |
| Singh AK et al. | Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. | 2015 | Clin. Cancer Res. | pmid:26130461 |
| Lee YR et al. | Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation. | 2015 | Oncotarget | pmid:26125438 |
| Thangavel J et al. | Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. | 2015 | J. Cell. Sci. | pmid:26116574 |
| Kanasaki H et al. | Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. | 2015 | Mol. Cell. Endocrinol. | pmid:26116234 |
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| Wang B et al. | Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. | 2014 | Oncol. Rep. | pmid:25224651 |
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| Chan ST et al. | Oral and intraperitoneal administration of quercetin decreased lymphocyte DNA damage and plasma lipid peroxidation induced by TSA in vivo. | 2014 | Biomed Res Int | pmid:24868531 |
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| Yang DH et al. | Dynamic rearrangement of F-actin is required to maintain the antitumor effect of trichostatin A. | 2014 | PLoS ONE | pmid:24846135 |
| Kumafuji M et al. | Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module. | 2014 | Genes Cells | pmid:24840924 |
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| Xie L et al. | Histone deacetylase inhibitors trichostatin A and vorinostat inhibit TGFβ2-induced lens epithelial-to-mesenchymal cell transition. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:24994865 |
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| Michalak P | Evidence for maternal imprinting of 45S ribosomal RNA genes in Xenopus hybrids. | 2014 | Dev. Genes Evol. | pmid:24477594 |
| Kong Q et al. | Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer. | 2014 | Stem Cell Rev | pmid:24510582 |
| Sassi Fde A et al. | Inhibitory activities of trichostatin a in U87 glioblastoma cells and tumorsphere-derived cells. | 2014 | J. Mol. Neurosci. | pmid:24464841 |
| Li H et al. | The histone deacetylase inhibitor trichostatin a promotes totipotency in the male gametophyte. | 2014 | Plant Cell | pmid:24464291 |
| Xiao W et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. | 2014 | J. Cell. Mol. Med. | pmid:24456602 |
| Oride A et al. | Trichostatin A specifically stimulates gonadotropin FSHβ gene expression in gonadotroph LβT2 cells. | 2014 | Endocr. J. | pmid:24430728 |
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| Xie M et al. | Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. | 2014 | Circulation | pmid:24396039 |
| Koriyama Y et al. | Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction. | 2014 | J. Pharmacol. Sci. | pmid:24389816 |
| Liu J et al. | DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells. | 2014 | Med. Oncol. | pmid:24338274 |
| Al-Rayyan N et al. | 5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines. | 2014 | Cancer Lett. | pmid:24513177 |
| Yang W et al. | Trichostatin A increases the levels of plasma gelsolin and amyloid beta-protein in a transgenic mouse model of Alzheimer's disease. | 2014 | Life Sci. | pmid:24486299 |
| Brglez V et al. | Secreted phospholipases Aâ‚‚are differentially expressed and epigenetically silenced in human breast cancer cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24508801 |
| Smith S et al. | Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. | 2014 | PLoS ONE | pmid:24466340 |
| Chen HY et al. | Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury. | 2014 | Pharmazie | pmid:24601225 |
| Bezecny P | Histone deacetylase inhibitors in glioblastoma: pre-clinical and clinical experience. | 2014 | Med. Oncol. | pmid:24838514 |
| Alsarraf O et al. | Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. | 2014 | Exp. Eye Res. | pmid:25064603 |
| Kanski R et al. | Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network. | 2014 | J. Cell. Sci. | pmid:25128567 |
| Hennig D et al. | Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: a study with peptides and HDAC inhibitors. | 2014 | Macromol Biosci | pmid:23966296 |