| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenomyosis | D062788 | 1 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Supratentorial Neoplasms | D015173 | 1 associated lipids |
| von Hippel-Lindau Disease | D006623 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim Y et al. | Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. | 2003 | Oncogene | pmid:12584561 |
| Mishra N et al. | Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. | 2003 | J. Clin. Invest. | pmid:12588892 |
| Glaser KB et al. | Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. | 2003 | Mol. Cancer Ther. | pmid:12589032 |
| Ailenberg M and Silverman M | Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604329 |
| Sakai N et al. | Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. | 2003 | J. Biol. Chem. | pmid:12609987 |
| Kim SY et al. | Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. | 2003 | J. Virol. | pmid:12610114 |
| Wang S and Zhu J | Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. | 2003 | J. Biol. Chem. | pmid:12611896 |
| Shaker S et al. | Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. | 2003 | Leuk. Res. | pmid:12620295 |
| James SY et al. | Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. | 2003 | Cancer Res. | pmid:12839938 |
| McGhee L et al. | Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. | 2003 | J. Cell. Biochem. | pmid:12874834 |
| Chun AC and Jin DY | Transcriptional regulation of mitotic checkpoint gene MAD1 by p53. | 2003 | J. Biol. Chem. | pmid:12876282 |
| Liu A et al. | Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. | 2003 | Glia | pmid:14603467 |
| Moreira JM et al. | The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. | 2003 | BMC Cancer | pmid:14606959 |
| Remiszewski SW et al. | N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824). | 2003 | J. Med. Chem. | pmid:14521422 |
| Noh EJ and Lee JS | Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2-M transition. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14521905 |
| Li C et al. | Effect and comparison of sodium butyrate and trichostatin A on the proliferation/differentiation of K562. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:14526425 |
| Krämer OH et al. | The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. | 2003 | EMBO J. | pmid:12840003 |
| Hejnar J et al. | Demethylation of host-cell DNA at the site of avian retrovirus integration. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14623319 |
| Witt O et al. | Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. | 2003 | Blood | pmid:12393499 |
| Kim MS et al. | Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. | 2003 | Cancer Res. | pmid:14612526 |
| Miller TA et al. | Histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14613312 |
| Hitomi T et al. | p15(INK4b) in HDAC inhibitor-induced growth arrest. | 2003 | FEBS Lett. | pmid:14623092 |
| Zhang Q et al. | Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. | 2003 | Toxicol. Appl. Pharmacol. | pmid:14575637 |
| Usenko T et al. | Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. | 2003 | Oncogene | pmid:14576829 |
| Vasudevan A et al. | Heterocyclic ketones as inhibitors of histone deacetylase. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592473 |
| Chung YL et al. | A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. | 2003 | Mol. Ther. | pmid:14599803 |
| Lu F et al. | Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. | 2003 | J. Virol. | pmid:14557628 |
| Siddiqui H et al. | Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition. | 2003 | Mol. Cell. Biol. | pmid:14560017 |
| Martin D et al. | Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines. | 2003 | J. Biol. Chem. | pmid:14565956 |
| Ferguson M et al. | Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. | 2003 | Nucleic Acids Res. | pmid:12799440 |
| Ji Y et al. | A multistep mechanism for the activation of rearrangement in the immune system. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12802019 |
| Nemajerová A et al. | Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. | 2003 | J. Hematother. Stem Cell Res. | pmid:12804181 |
| Park PH et al. | Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12804592 |
| Kim H et al. | The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816733 |
| Klan N et al. | Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. | 2003 | Biol. Chem. | pmid:12817474 |
| Yamada Y et al. | Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer. | 2003 | Cancer Sci. | pmid:12824880 |
| Shi W et al. | Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. | 2003 | Biol. Reprod. | pmid:12646489 |
| Murumägi A et al. | Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. | 2003 | J. Biol. Chem. | pmid:12651856 |
| Kang J et al. | Nickel-induced histone hypoacetylation: the role of reactive oxygen species. | 2003 | Toxicol. Sci. | pmid:12773760 |
| Maatouk DM and Resnick JL | Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation. | 2003 | Dev. Biol. | pmid:12781693 |
| Schauber J et al. | Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. | 2003 | Gut | pmid:12692061 |
| Rambhatla L et al. | Generation of hepatocyte-like cells from human embryonic stem cells. | 2003 | Cell Transplant | pmid:12693659 |
| Lee SC et al. | Activation of terminal B cell differentiation by inhibition of histone deacetylation. | 2003 | Mol. Immunol. | pmid:12695118 |
| Chandler SP et al. | Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. | 2003 | BMC Mol. Biol. | pmid:12659659 |
| Zika E et al. | Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. | 2003 | Mol. Cell. Biol. | pmid:12697811 |
| Mihaylova VT et al. | Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. | 2003 | Mol. Cell. Biol. | pmid:12697826 |
| Kao GD et al. | Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. | 2003 | J. Cell Biol. | pmid:12668657 |
| Yasui W et al. | Histone acetylation and gastrointestinal carcinogenesis. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12724227 |
| Jedrusik MA and Schulze E | Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing. | 2003 | Mol. Cell. Biol. | pmid:12724425 |
| Vos MD et al. | The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. | 2003 | J. Biol. Chem. | pmid:12676952 |